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1.14.19.29: sphingolipid 8-(E/Z)-desaturase

This is an abbreviated version!
For detailed information about sphingolipid 8-(E/Z)-desaturase, go to the full flat file.

Reaction

Show molfile
a (4R)-4-hydroxysphinganine ceramide
+ 2 ferrocytochrome b5 +
Show molfile
O2
+ 2 H+ =
Show molfile
a (4R,8E)-4-hydroxysphing-8-enine ceramide
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8 Des, Delta8 sphingolipid desaturase, DELTA8(E,Z)-sphingolipid desaturase, Delta8-fatty-acid desaturase 1, Delta8-fatty-acid desaturase 2, DELTA8-sphingolipid desaturase, Delta8-sphingolipid desaturase 1, Delta8-sphingolipid desaturase 2, Delta8-sphingolipid desaturase 3, DELTA8-sphingolipid-desaturase, DES8, DXDES, LCB DELTA8 desaturase, PtD8A, PtD8B, PtD8C, SLD, SLD1, SLD2, sphingoid long-chain base DELTA8 desaturase, sphingolipid DELTA8-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                EC 1.14.19.291.14.19.29 sphingolipid 8-(E/Z)-desaturase

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Resultsin table
29AA Sequence
39Cloned(Commentary)
27Cofactor
19General Information
3Localization
58Natural Substrates/ Products (Substrates)
40Organism
1Pathway
15Protein Variants
1Purification (Commentary)
4Reaction
29Reference
33Source Tissue
80Substrates and Products (Substrate)
73Synonyms
1Systematic Name
All data fields related to EC 1.14.19.29

Reference

Reference on EC 1.14.19.29 - sphingolipid 8-(E/Z)-desaturase

for references in articles please use BRENDA:EC1.14.19.29

Please use the Reference Search for a specific query.

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sperling, P.; Libisch, B.; Zahringer, U.; Napier, J.A.; Heinz, E.
Functional identification of a DELTA8-sphingolipid desaturase from Borago officinalis
Arch. Biochem. Biophys.
388
293-298
2001
Borago officinalis, Borago officinalis (Q9FR82)
Manually annotated by BRENDA team
Libisch, B.; Michaelson, L.V.; Lewis, M.J.; Shewry, P.R.; Napier, J.A.
Chimeras of DELTA6-fatty acid and DELTA8-sphingolipid desaturases
Biochem. Biophys. Res. Commun.
279
779-785
2000
Borago officinalis (Q9FR82)
Manually annotated by BRENDA team
Sperling, P.; Blume, A.; Zahringer, U.; Heinz, E.
Further characterization of DELTA8-sphingolipid desaturases from higher plants
Biochem. Soc. Trans.
28
638-641
2000
Arabidopsis thaliana, Brassica napus, Helianthus annuus (Q43469)
Manually annotated by BRENDA team
Beckmann Christop, B.C.; Rattke Janin, R.J.; Oldham Neil, O.N.; Sperling Petr, S.P.; Heinz Erns, H.E.; Boland Wilhel, B.W.
Characterization of a DELTA8-sphingolipid desaturase from higher plants: a stereochemical and mechanistic study on the origin of E,Z isomers
Angew. Chem. Int. Ed. Engl.
41
2298-2300
2002
Helianthus annuus, Helianthus annuus (Q43469)
Manually annotated by BRENDA team
Ryan, P.R.; Liu, Q.; Sperling, P.; Dong, B.; Franke, S.; Delhaize, E.
A higher plant DELTA8 sphingolipid desaturase with a preference for (Z)-isomer formation confers aluminum tolerance to yeast and plants
Plant Physiol.
144
1968-1977
2007
Stylosanthes hamata (A7Y7E1)
Manually annotated by BRENDA team
Oura, T.; Kajiwara, S.
Disruption of the sphingolipid DELTA8-desaturase gene causes a delay in morphological changes in Candida albicans
Microbiology
154
3795-3803
2008
Candida albicans, Candida albicans TUA6
Manually annotated by BRENDA team
Habel, A.; Sperling, P.; Bartram, S.; Heinz, E.; Boland, W.
Conformational studies on the DELTA8(E,Z)-sphingolipid desaturase from Helianthus annuus with chiral fluoropalmitic acids as mechanistic probes
J. Org. Chem.
75
4975-4982
2010
Helianthus annuus
Manually annotated by BRENDA team
Li, S.F.; Song, L.Y.; Zhang, G.J.; Yin, W.B.; Chen, Y.H.; Wang, R.R.; Hu, Z.M.
Newly identified essential amino acid residues affecting DELTA8-sphingolipid desaturase activity revealed by site-directed mutagenesis
Biochem. Biophys. Res. Commun.
416
165-171
2011
Brassica rapa (G9I7G1)
Manually annotated by BRENDA team
Song, L.; Zhang, Y.; Li, S.; Hu, J.; Yin, W.; Chen, Y.; Hao, S.; Wang, B.; Wang, R.; Hu, Z.
Identification of the substrate recognition region in the DELTA6-fatty acid and DELTA8-sphingolipid desaturase by fusion mutagenesis
Planta
239
753-763
2014
Ribes nigrum
Manually annotated by BRENDA team
Li, S.; Zhang, G.; Yuan, Y.; Wang, C.; Gao, W.; Deng, C.; Lu, L.; Hu, Z.
Three homologous genes encoding functional DELTA8-sphingolipid desaturase in Populus tomentosa
Genes Genomics
36
293-301
2014
Populus tomentosa
-
Manually annotated by BRENDA team
Chen, M.; Markham, J.; Cahoon, E.
Sphingolipid DELTA8 unsaturation is important for glucosylceramide biosynthesis and low-temperature performance in Arabidopsis
Plant J.
69
769-781
2012
Arabidopsis thaliana
Manually annotated by BRENDA team
Garcia-Maroto, F.; Garrido-Cardenas, J.A.; Michaelson, L.V.; Napier, J.A.; Alonso, D.L.
Cloning and molecular characterisation of a DELTA8-sphingolipid-desaturase from Nicotiana tabacum closely related to DELTA6-acyl-desaturases
Plant Mol. Biol.
64
241-250
2007
Nicotiana tabacum (A4GK73), Nicotiana tabacum
Manually annotated by BRENDA team
Li, S.; Zhang, G.; Yuan, Y.; Wang, C.; Gao, W.; Deng, C.; Lu, L.; Hu, Z.
Three homologous genes encoding functional DELTA8-sphingolipid desaturase in Populus tomentosa
Genes Genomics
36
293-301
2014
Populus tomentosa
-
Manually annotated by BRENDA team
Li, S.F.; Zhang, G.J.; Zhang, X.J.; Yuan, J.H.; Deng, C.L.; Hu, Z.M.; Gao, W.J.
Genes encoding DELTA8-sphingolipid desaturase from various plants identification, biochemical functions, and evolution
J. Plant Res.
129
979-987
2016
Aquilegia vulgaris (Q8LLD7), Arabidopsis thaliana (Q3EBF7), Arabidopsis thaliana (Q9ZRP7), Borago officinalis (Q9FR82), Brachypodium distachyon (I1IPG5), Carica papaya (A0A193BIJ7), Cucumis sativus (A0A0A0KA29), Glycine max (I1J5P4), Glycine max (I1KXS8), Glycine max (I1MXA6), Populus tomentosa (W8DT12), Populus tomentosa (W8DT41), Populus tomentosa (W8DTJ8), Prunus persica (M5X146), Prunus persica (M5X679), Prunus persica (M5XCX6), Ricinus communis (B9RDZ7), Sorghum bicolor (C5XAI0), Triticum aestivum (Q9ZTU8), Triticum aestivum (W5FYY9), Vitis vinifera (F6H3N5), Vitis vinifera (F6I678)
Manually annotated by BRENDA team