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1.14.15.11: pentalenic acid synthase

This is an abbreviated version!
For detailed information about pentalenic acid synthase, go to the full flat file.

Wordmap for 1.14.15.11

Word Map on EC 1.14.15.11 Wordmap for 1.14.15.11

Reaction

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1-deoxypentalenate
+
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reduced ferredoxin
 +
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O2
=
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pentalenate
 +
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oxidized ferredoxin
 +
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H2O

Synonyms

CYP105D7, CYP28, pentalenic acid synthase, sav7469, SAV_7469

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                EC 1.14.15.111.14.15.11 pentalenic acid synthase

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Resultsin table
127AA Sequence
3Cloned(Commentary)
1Cofactor
2Crystallization (Commentary)
1General Information
2kcat/KM [mM/s]
4KM Value [mM]
9Organism
3Pathway
1PDB ID
1pH Optimum
1Reaction
7Reference
14Substrates and Products (Substrate)
4Subunits
14Synonyms
1Systematic Name
2Turnover Number [1/s]

Crystallization

Crystallization on EC 1.14.15.11 - pentalenic acid synthase

for references in articles please use BRENDA:EC1.14.15.11

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with diclofenac, at 2.2 A resolution. The distal pocket of CYP105D7 contains two diclofenac molecules. The C3' and C4' atoms of the dichlorophenyl ring of one diclofenac molecule are positioned near the heme iron
molecular docking of compactin, compactin is directly hydrogen bonded with residues Thr79, Arg81, Leu178, Thr391, and Ile392 and its C6 position is proximate to the heme group. Molecular docking of diclofenac