EC 1.1.98.2: glucose-6-phosphate dehydrogenase (coenzyme-F420)

This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase (coenzyme-F420), go to the full flat file.

Reaction

Synonyms

Rv0407, coenzyme F420-dependent glucose-6-phosphate dehydrogenase, EC 1.1.99.34, F420-dependent glucose-6-phosphate dehydrogenase, FGD, FGD1, glucose-6-phosphate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.98 With other, known, physiological acceptors

                1.1.98.2 glucose-6-phosphate dehydrogenase (coenzyme-F420)

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All data fields related to EC 1.1.98.2

Results	in table
792	AA Sequence
1	Application
2	CAS Registry Number
7	Cloned(Commentary)
19	Cofactor
3	Crystallization (Commentary)
4	General Information
1	IC50 Value
2	Inhibitors
16	kcat/KM [mM/s]
18	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
663	Organism
2	PDB ID
18	pH Optimum
1	pH Range
8	Protein Variants
6	Purification (Commentary)
1	Reaction
665	Reference
15	Specific Activity [micromol/min/mg]
2	Storage Stability
49	Substrates and Products (Substrate)
3	Subunits
48	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Stability [°C]
16	Turnover Number [1/s]

Substrates Products

Substrates Products on EC 1.1.98.2 - glucose-6-phosphate dehydrogenase (coenzyme-F420)

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

D-fructose 6-phosphate + oxidized coenzyme F420

? + reduced coenzyme F420

Rhodococcus jostii

-

739925

Substrates: 4.8% activity compared to D-glucose 6-phosphate
Products: -

?

D-fructose-6-phosphate + oxidized coenzyme F420

?

Mycolicibacterium smegmatis

-

698547

Substrates: 9% of the activity with 2 mM D-glucose 6-phosphate
Products: -

?

D-glucosamine 6-phosphate + oxidized coenzyme F420

?

Rhodococcus jostii

-

739925

Substrates: 2.8% activity compared to D-glucose 6-phosphate
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

5 entries

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

33 entries

D-mannose 6-phosphate + oxidized coenzyme F420

6-phospho-D-mannono-1,5-lactone + reduced coenzyme F420

Rhodococcus jostii

-

739925

Substrates: 1.1% activity compared to D-glucose 6-phosphate
Products: -

?

D-mannose-6-phosphate + oxidized coenzyme F420

?

Mycolicibacterium smegmatis

-

698547

Substrates: 5% of the activity with 2 mM D-glucose 6-phosphate
Products: -

?

additional information

?

-

2 entries

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Mycobacterium tuberculosis

-

723589

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Mycobacterium tuberculosis

Q0RVH7

740083

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Mycobacterium tuberculosis H37Rv

-

723589

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Rhodococcus jostii

-

739925

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Rhodococcus jostii

-

739925

Substrates: 100% activity
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Gordonia amarae

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Gordona amarae: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Gordonia amarae

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium avium

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium avium: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium avium

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium gordonae

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium gordonae: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium gordonae

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium kansasii

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium kansasii: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium kansasii

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium leprae

-

697967

Substrates: -
Products: -

ir, ?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium scrofulaceum

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium scrofulaceum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium scrofulaceum

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis

-

697967, 701052

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Ra / ATCC 25177

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Ra / ATCC 25177

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Ra / ATCC 25177

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Rv

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Rv

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Rv

-

697967, 701052

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium fortuitum

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium fortuitum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium fortuitum

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium smegmatis

-

698547

Substrates: there are to separate glucose-6-phosphate dehydrogenase activities in Mycobacterium smegmatis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium smegmatis

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium smegmatis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium smegmatis

-

698547

Substrates: the purified enzyme used F420 as its obligate electron acceptor when D-glucose 6-phosphate is the substrate. NAD, NADP, flavin adenine dinucleotide, and flavin mononucleotide show no reactivity. The enzyme is very specific for D-glucose 6-phosphate. At pH 7.0 and 22°C, 10 mM D-mannose-6-phosphate and D-fructose-6-phosphate show 5% and 9%, respectively, of the activity with 2 mM D-glucose 6-phosphate. No activity with: D-fructose-1-phosphate, D-galactose-1-phosphate, D-galactose-6-phosphate, L-fucose-1-phosphate, D-glucose-1-phosphate, D-ribose-5-phosphate, D-ribose-1-phosphate, D-arabinose-5-phosphate, glyceraldehyde-3-phosphate, and glycerol-3-phosphate
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium smegmatis

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia asteroides

-

697967

Substrates: -
Products: -

ir, ?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia brasiliensis

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia brasiliensis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia brasiliensis

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia otitidiscaviarum

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia otitidiscaviarum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia otitidiscaviarum

-

697967

Substrates: -
Products: -

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia tartaricans

-

697967

Substrates: there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia tartaricans: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
Products: -

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia tartaricans

-

697967

Substrates: -
Products: -

?

additional information

?

-

Mycolicibacterium smegmatis

-

699008

Substrates: intracellular glucose-6-phosphate in mycobacteria serves as a source of reducing power, and with the mycobacteria-specific F420-dependent glucose-6-phosphate dehydrogenase/F420 system, plays a protective role against oxidative stress imposed by host macrophages
Products: -

?

additional information

?

-

Rhodococcus jostii

-

739925

Substrates: there is no detectable enzyme activity with alpha-Dglucose 1-phosphate and alpha-D-galactose 1-phosphate. The enzyme also accepts D-glucose as substrate, although with very low catalytic activity
Products: -

?