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1.1.3.6: cholesterol oxidase

This is an abbreviated version!
For detailed information about cholesterol oxidase, go to the full flat file.

Word Map on EC 1.1.3.6

Reaction

cholesterol
+
O2
=
cholest-5-en-3-one
+
H2O2

Synonyms

3beta-hydroxy steroid oxidoreductase, 3beta-hydroxysteroid: oxygen oxidoreductase, 3beta-hydroxysteroid:oxygen oxidoreductase, 3beta-hydroxysterol oxidase, BsChOx, CgChoA, CHO, CHO-U, ChO3, ChoA, choBb, CHOD, ChoG, ChoL, cholesterol oxidase, cholesterol oxidase I, cholesterol oxidase II, cholesterol-O2 oxidoreductase, CHOLOX, choM, ChoM1, ChoM2, choP, ChoRI, ChoRII, ChoS, ChOx, CO, CO1, COase, COD, COD-B, COX, HCEO-forming enzyme, HMPREF0204_11499, oxidase, cholesterol, PimE, ShChOx, type I ChOx

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.3 With oxygen as acceptor
                1.1.3.6 cholesterol oxidase

Substrates Products

Substrates Products on EC 1.1.3.6 - cholesterol oxidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,4-androstadiene-3,17-dione + H2O
?
show the reaction diagram
-
11% of the activity with cholesterol, enzyme CO1
-
-
?
1-propanol + O2
propanal + H2O2
show the reaction diagram
-
-
-
?
17beta-hydroxymethyl-5-androsten-3beta-ol + O2
17beta-hydroxymethyl-5-androsten-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
20,22-dihydroxycholesterol + O2
20,22-dihydroxycholest-5-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
20,25-diazacholesterol + O2
20,25-diazacholest-4-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
20-hydroxycholesterol + O2
20-hydroxycholest-5-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
22-hydroxycholesterol + O2
22-hydroxycholest-5-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
23,24-dinor-5-cholen-3beta,22-diol + O2
23,24-dinor-5-cholen-22-ol-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
23,24-dinor-5-cholene-3beta,22-diol + O2
23,24-dinor-5-cholen-22-ol-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
-
r
24-hydroxycholesterol + O2
24-hydroxycholest-5-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
24-oxocholesterol + O2
24-oxocholest-5-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
25-hydroxy-27-norcholesterol + O2
?
show the reaction diagram
Nocardia erythropolis
-
-
-
-
?
25-hydroxycholesterol + O2
25-hydroxycholest-5-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
26-hydroxycholesterol + O2
26-hydroxycholest-5-en-3-one + H2O2
show the reaction diagram
3-betacholestanol + O2
? + H2O2
show the reaction diagram
3beta-chlorocholest-5-ene + O2
? + H2O2
show the reaction diagram
3beta-hydroxyandrost-5-en-17-one + O2
androst-5-en-3,17-dione + H2O2
show the reaction diagram
3beta-hydroxypregn-5-en-20-one + O2
pregn-5-en-3,20-dione + H2O2
show the reaction diagram
4,4-dimethylcholesterol + O2
4,4-dimethylcholest-5-en-3-one
show the reaction diagram
Nocardia erythropolis
-
-
-
?
4alpha-methylcholesterol + O2
4alpha-methylcholest-5-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
4beta-methylcholesterol + O2
4beta-methylcholest-5-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
5,7-cholestadien-3beta-ol + O2
5,7-cholestadien-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
5-androstene-3beta,17beta-diol + O2
5-androsten-17beta-ol-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
5-cholene-3beta,24-diol + O2
5-cholen-24-ol-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
5-pregnen-3,20-dione + O2
pregnenolone + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
-
r
5-pregnen-3beta,20beta-diol + O2
5-pregnen-20beta-ol-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
5alpha-androstan-3-ol-17-one + O2
5alpha-androstan-3,17-dione + H2O2
show the reaction diagram
-
15% of the activity with cholesterol
-
-
?
5alpha-cholest-8(14)-en-3beta-ol + O2
5alpha-cholest-8(14)-en-3-one + H2O2
show the reaction diagram
Nocardia erythropolis
-
-
-
?
5alpha-cholestan-3beta-ol + O2
5alpha-cholestan-3-one + H2O2
show the reaction diagram
5alpha-cholestane + O2
?
show the reaction diagram
5alpha-cholestane-3beta-ol-7-one + O2
5alpha-cholestane-3,7,dione
show the reaction diagram
7-dehydrocholesterol + O2
cholest-4,7-dien-3-one + H2O2
show the reaction diagram
7-keto-cholesterol + O2
?
show the reaction diagram
7alpha-hydroxy-cholesterol + O2
7alpha-hydroxy-cholest-4-en-3-one + H2O2
show the reaction diagram
7beta-hydroxy-cholesterol + O2
7beta-hydroxy-cholest-4-en-3-one + H2O2
show the reaction diagram
7E,22-ergostadien-3beta-ol + O2
7E,22-ergostadien-3-one + H2O2
show the reaction diagram
androst-4-ene-3,17-dione + O2
? + H2O2
show the reaction diagram
-
-
-
?
beta-cholestanol + O2
?
show the reaction diagram
beta-cholestanol + O2
? + H2O2
show the reaction diagram
beta-sitosterol + O2
?
show the reaction diagram
beta-sitosterol + O2
? + H2O2
show the reaction diagram
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
show the reaction diagram
beta-stigmasterol + O2
?
show the reaction diagram
-
36% of the activity with cholesterol
-
-
?
beta-stigmasterol + O2
? + H2O2
show the reaction diagram
-
68% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
show the reaction diagram
campesterol + O2
(24R)-ergost-5-en-3-one + H2O2
show the reaction diagram
cholest-4-en-3-one + O2
? + H2O2
show the reaction diagram
-
-
-
?
cholest-5-en-3beta-ol 7-one + O2
cholest-5-en-3,17-dione + H2O2
show the reaction diagram
-
low activity with wild-type and mutant enzymes L119A, L119F, V145Q, P357N, Q286R and S379T
-
-
?
cholestanol + O2
?
show the reaction diagram
cholestenol + O2
5alpha-cholest-8-en-3-one + H2O2
show the reaction diagram
-
43% activity compared to cholesterol
-
-
?
cholestenone + O2
?
show the reaction diagram
cholesterol + O2
6beta-hydroxycholest-4-en-3-one + H2O2
show the reaction diagram
cholesterol + O2
cholest-4-en-3-one + H2O2
show the reaction diagram
cholesterol + O2
cholest-5-en-3-one + H2O2
show the reaction diagram
cholesterol-5alpha,6beta-epoxide + O2
?
show the reaction diagram
coprostane + O2
?
show the reaction diagram
cyclohexanol + O2
cyclohexanal + H2O2
show the reaction diagram
-
-
-
?
dehydro-epi-androsterone + O2
?
show the reaction diagram
dehydroandrosterone + O2
? + H2O2
show the reaction diagram
-
-
-
?
dehydroepiandrosterone + O2
?
show the reaction diagram
-
27% of the activity with cholesterol
-
-
?
dehydroepiandrosterone + O2
? + H2O2
show the reaction diagram
-
30% activity compared to cholesterol
-
-
?
dehydroepiandrosterone + O2
androst-5-en-3,17-dione + H2O2
show the reaction diagram
dehydroisoandrosterone + O2
androst-5-en-3,17-dione + H2O
show the reaction diagram
desmosterol + O2
cholesta-5,24-dien-3-one + H2O2
show the reaction diagram
dihydrocholesterol + O2
5alpha-cholestan-3-one + H2O2
show the reaction diagram
diosgenin + O2
? + H2O2
show the reaction diagram
-
-
-
?
diosgenin + O2
diosgenone + H2O2
show the reaction diagram
epiandrosterone + O2
?
show the reaction diagram
epiandrosterone + O2
? + H2O2
show the reaction diagram
-
15% activity compared to cholesterol
-
-
?
ergosta-5,7,22-trien-3beta-ol + O2
ergostan-5,7,22-trien-3-one + H2O2
show the reaction diagram
-
18% of the activity with cholesterol
-
-
?
ergosterol + O2
?
show the reaction diagram
ergosterol + O2
? + H2O2
show the reaction diagram
ergosterol + O2
dehydroergosterol + H2O2
show the reaction diagram
estrone + O2
estra-1,5(10)-dien-3,17-dione + H2O2
show the reaction diagram
-
low activity with wild-type enzyme, no activity with mutant enzymes L119A, L119F, V145Q, P357N, Q286R and S379T
-
-
?
ethanol + O2
ethanal + H2O2
show the reaction diagram
-
-
-
?
fucosterol + O2
stigmasta-5,24(28)-dien-3-one + H2O2
show the reaction diagram
hecogenin + O2
5alpha-(25R)-spirostan-3,12-dione + H2O2
show the reaction diagram
lanosterol + O2
5alpha-lanosta-8,24-dien-3-one + H2O2
show the reaction diagram
lanosterol + O2
lanosta-8,24-dien-3-one + H2O2
show the reaction diagram
-
slow rate
-
?
methanol + O2
methanal + H2O2
show the reaction diagram
-
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
show the reaction diagram
pregnenolone + O2
?
show the reaction diagram
pregnenolone + O2
? + H2O2
show the reaction diagram
pregnenolone + O2
pregn-5-ene-3,20-dione + H2O2
show the reaction diagram
low activity
-
-
?
sitost-5-en-3beta-ol + O2
sitost-5-en-3-one + H2O2
show the reaction diagram
-
88% of the activity with cholesterol
-
-
?
sitosterol + O2
?
show the reaction diagram
stigmast-5-en-3beta-ol + O2
stigmast-5-en-3-one + H2O2
show the reaction diagram
-
68% of the activity with cholesterol
-
-
?
stigmastanol + O2
stigmastanone + H2O2
show the reaction diagram
stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
show the reaction diagram
taurocholate + O2
? + H2O2
show the reaction diagram
trans-androsterone + O2
?
show the reaction diagram
trans-dehydroandrosterone + O2
?
show the reaction diagram
additional information
?
-