1.1.3.6: cholesterol oxidase
This is an abbreviated version!
For detailed information about cholesterol oxidase, go to the full flat file.
Word Map on EC 1.1.3.6
-
1.1.3.6
-
biosensors
-
electrode
-
esterase
-
electrochemical
-
brevibacterium
-
fabric
-
oxidases
-
amperometric
-
film
-
rhodococcus
-
raft
-
cholestenone
-
voltammetry
-
cholest-4-en-3-one
-
flavoenzyme
-
cholesteryl
-
nanocomposite
-
biosensing
-
erythropolis
-
filipin
-
4-cholesten-3-one
-
nocardia
-
medicine
-
3hcholesterol
-
electropolymerization
-
lavendulae
-
biotechnology
-
agriculture
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co-immobilized
-
methyl-beta-cyclodextrin
-
diagnostics
-
bioelectrode
-
luminol
-
screen-printed
-
electrocatalytic
-
analysis
-
3.1.1.13
-
polypyrrole
-
multiwalled
-
beta-ol
-
synthesis
-
drug development
- 1.1.3.6
-
biosensors
-
electrode
- esterase
-
electrochemical
- brevibacterium
-
fabric
- oxidases
-
amperometric
-
film
- rhodococcus
-
raft
- cholestenone
-
voltammetry
- cholest-4-en-3-one
-
flavoenzyme
-
cholesteryl
-
nanocomposite
-
biosensing
- erythropolis
- filipin
- 4-cholesten-3-one
- nocardia
- medicine
-
3hcholesterol
-
electropolymerization
- lavendulae
- biotechnology
- agriculture
-
co-immobilized
- methyl-beta-cyclodextrin
- diagnostics
-
bioelectrode
- luminol
-
screen-printed
-
electrocatalytic
- analysis
-
3.1.1.13
-
polypyrrole
-
multiwalled
- beta-ol
- synthesis
- drug development
Reaction
Synonyms
3beta-hydroxy steroid oxidoreductase, 3beta-hydroxysteroid: oxygen oxidoreductase, 3beta-hydroxysteroid:oxygen oxidoreductase, 3beta-hydroxysterol oxidase, BsChOx, CgChoA, CHO, CHO-U, ChO3, ChoA, choBb, CHOD, ChoG, ChoL, cholesterol oxidase, cholesterol oxidase I, cholesterol oxidase II, cholesterol-O2 oxidoreductase, CHOLOX, choM, ChoM1, ChoM2, choP, ChoRI, ChoRII, ChoS, ChOx, CO, CO1, COase, COD, COD-B, COX, HCEO-forming enzyme, HMPREF0204_11499, oxidase, cholesterol, PimE, ShChOx, type I ChOx
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.1.3.6 - cholesterol oxidase
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REACTION DIAGRAM
3beta-chlorocholest-5-ene + O2
? + H2O2
low activity
-
-
?
?
13% activity compared to cholesterol
-
-
?
beta-cholestanol + O2
?
69% activity compared to cholesterol
-
-
?
beta-cholestanol + O2
?
95% activity compared to cholesterol
-
-
?
beta-cholestanol + O2
?
75% activity compared to cholesterol
-
-
?
beta-cholestanol + O2
?
-
101% activity compared to cholesterol
-
-
?
beta-cholestanol + O2
?
Streptoverticillium cholesterolieum
-
96% activity compared to cholesterol
-
-
?
beta-cholestanol + O2
?
-
79% activity compared to cholesterol
-
-
?
beta-cholestanol + O2
?
-
79% activity compared to cholesterol
-
-
?
stigmast-5-en-3-one + H2O2
20% activity compared to cholesterol
-
-
?
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
84% activity compared to cholesterol
-
-
?
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
84% activity compared to cholesterol
-
-
?
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
80% activity compared to cholesterol
-
-
?
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
Corynebacterium cholesterolicum
-
50% activity compared to cholesterol
-
-
?
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
72% activity compared to cholesterol
-
-
?
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
-
64% activity compared to cholesterol
-
-
?
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
Streptoverticillium cholesterolieum
-
39% activity compared to cholesterol
-
-
?
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
-
29% activity compared to cholesterol
-
-
?
beta-sitosterol + O2
stigmast-5-en-3-one + H2O2
-
29% activity compared to cholesterol
-
-
?
stigmasta-5,22-dien-3-one + H2O2
10% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
59% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
36% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
Corynebacterium cholesterolicum
-
12% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
-
47% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
-
40% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
-
40% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
37% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
-
50% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
Streptoverticillium cholesterolieum
-
17% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
-
32% activity compared to cholesterol
-
-
?
beta-stigmasterol + O2
stigmasta-5,22-dien-3-one + H2O2
-
32% activity compared to cholesterol
-
-
?
6beta-hydroxycholest-4-en-3-one + H2O2
-
-
-
?
cholesterol + O2
6beta-hydroxycholest-4-en-3-one + H2O2
-
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
100% activity
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
100% activity
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
Corynebacterium cholesterolicum
-
100% activity
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
-
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
-
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
-
cholesterol oxidase is required for the biosynthesis of the antifungal polyene pimaricin
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
100% activity
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
-
cholesterol oxidase is required for the biosynthesis of the antifungal polyene pimaricin, apparently acting as an antifungal sensor
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
-
via cholest-5-en-3-one
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
via cholest-5-en-3-one
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
Streptoverticillium cholesterolieum
-
100% activity
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
-
100% activity
-
-
?
cholesterol + O2
cholest-4-en-3-one + H2O2
-
100% activity
-
-
?
cholesterol + O2
cholest-5-en-3-one + H2O2
-
first step in cholesterol degradation
-
?
cholesterol + O2
cholest-5-en-3-one + H2O2
Nocardia erythropolis
-
first step in cholesterol degradation
-
?
cholesterol + O2
cholest-5-en-3-one + H2O2
Nocardia rhodochrous
-
first step in cholesterol degradation
-
?
cholesterol + O2
cholest-5-en-3-one + H2O2
-
first step in cholesterol degradation
-
?
androst-5-en-3,17-dione + H2O2
41% activity compared to cholesterol
-
-
?
dehydroepiandrosterone + O2
androst-5-en-3,17-dione + H2O2
16% activity compared to cholesterol
-
-
?
dehydroepiandrosterone + O2
androst-5-en-3,17-dione + H2O2
16% activity compared to cholesterol
-
-
?
dehydroepiandrosterone + O2
androst-5-en-3,17-dione + H2O2
27% activity compared to cholesterol
-
-
?
dehydroepiandrosterone + O2
androst-5-en-3,17-dione + H2O2
Corynebacterium cholesterolicum
-
5% activity compared to cholesterol
-
-
?
dehydroepiandrosterone + O2
androst-5-en-3,17-dione + H2O2
-
28% activity compared to cholesterol
-
-
?
dehydroepiandrosterone + O2
androst-5-en-3,17-dione + H2O2
24% activity compared to cholesterol
-
-
?
dehydroepiandrosterone + O2
androst-5-en-3,17-dione + H2O2
-
37% activity compared to cholesterol
-
-
?
dehydroepiandrosterone + O2
androst-5-en-3,17-dione + H2O2
Streptoverticillium cholesterolieum
-
48% activity compared to cholesterol
-
-
?
?
10% activity compared to cholesterol
-
-
?
dehydroergosterol + H2O2
20% activity compared to cholesterol
-
-
?
ergosterol + O2
dehydroergosterol + H2O2
20% activity compared to cholesterol
-
-
?
ergosterol + O2
dehydroergosterol + H2O2
12% activity compared to cholesterol
-
-
?
ergosterol + O2
dehydroergosterol + H2O2
Corynebacterium cholesterolicum
-
4% activity compared to cholesterol
-
-
?
ergosterol + O2
dehydroergosterol + H2O2
-
17% activity compared to cholesterol
-
-
?
ergosterol + O2
dehydroergosterol + H2O2
-
51% activity compared to cholesterol
-
-
?
ergosterol + O2
dehydroergosterol + H2O2
-
51% activity compared to cholesterol
-
-
?
ergosterol + O2
dehydroergosterol + H2O2
12% activity compared to cholesterol
-
-
?
ergosterol + O2
dehydroergosterol + H2O2
-
14% activity compared to cholesterol
-
-
?
ergosterol + O2
dehydroergosterol + H2O2
Streptoverticillium cholesterolieum
-
5% activity compared to cholesterol
-
-
?
5-pregnen-3,20-dione + H2O2
22% activity compared to cholesterol
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
32% activity compared to cholesterol
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
32% activity compared to cholesterol
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
95% activity compared to cholesterol
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
Corynebacterium cholesterolicum
-
38% activity compared to cholesterol
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
-
6% activity compared to cholesterol
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
-
20% activity compared to cholesterol
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
99% activity compared to cholesterol
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
-
42% activity compared to cholesterol
-
-
?
pregnenolone + O2
5-pregnen-3,20-dione + H2O2
Streptoverticillium cholesterolieum
-
37% activity compared to cholesterol
-
-
?
?
-
no activity with ergosterol
-
-
?
additional information
?
-
cholesterol oxidase is a bifunctional enzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one while dioxygen is finally reduced to H2O2 as by-product. The enzymatic overall cholesterol oxidation comprises three steps. In the first one the 3beta-OH group of cholesterol is oxidized to the corresponding ketone with the concomitant reduction of the FAD cofactor. In a second step an isomerization of the double bond from the DELTA5-6 position to the DELTA4-5 position takes place. The FAD is recycled in a redox reaction with dioxygen, yielding hydrogen peroxide
-
-
?
additional information
?
-
-
cholesterol oxidase is a bifunctional enzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one while dioxygen is finally reduced to H2O2 as by-product. The enzymatic overall cholesterol oxidation comprises three steps. In the first one the 3beta-OH group of cholesterol is oxidized to the corresponding ketone with the concomitant reduction of the FAD cofactor. In a second step an isomerization of the double bond from the DELTA5-6 position to the DELTA4-5 position takes place. The FAD is recycled in a redox reaction with dioxygen, yielding hydrogen peroxide
-
-
?
additional information
?
-
cholesterol oxidase is a bifunctional enzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one while dioxygen is finally reduced to H2O2 as by-product. The enzymatic overall cholesterol oxidation comprises three steps. In the first one the 3beta-OH group of cholesterol is oxidized to the corresponding ketone with the concomitant reduction of the FAD cofactor. In a second step an isomerization of the double bond from the DELTA5-6 position to the DELTA4-5 position takes place. The FAD is recycled in a redox reaction with dioxygen, yielding hydrogen peroxide
-
-
?
additional information
?
-
-
intact ChoD is important for the growth of Mycobacterium tuberculosis in peritoneal macrophages and lungs of mice. Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis
-
-
?
additional information
?
-
-
no activity with dehydroepiandrosterone
-
-
?
additional information
?
-
the oxidation of the allylic alcohols by cholesterol oxidase from Rhodococcus erythropolis is stereo- and enantioselective. The enzyme oxidizes (S)-alcohol at a higher rate than (R)-alcohol
-
-
?
additional information
?
-
-
cholesterol oxidase is involved in pimaricin biosynthesis
-
-
?
additional information
?
-
-
cholesterol oxidase is a bifunctional FAD-containing oxidoreductase which catalyzes the oxidation and isomerization of cholesterol into 4-cholesten-3-one
-
-
?
additional information
?
-
cholesterol oxidase is a bifunctional flavoenzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one
-
-
?
additional information
?
-
-
no activity with ergosterol, pregnenolone, dehydroepiandrosterone, and epiandosterone
-
-
?
additional information
?
-
-
no activity with ergosterol, pregnenolone, dehydroepiandrosterone, and epiandosterone
-
-
?