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rectum, sigmoid colon
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
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aldosterone-sensitive, NAD+ specificity
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of the penis
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
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expression of mRNA for 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2 and for glucocorticoid receptor during the estrous cycle. Level of 11beta-hydroxysteroid dehydrogenase type 1 mRNA is higher at the regressed state than at the other stages, whereas level of 11beta-hydroxysteroid dehydrogenase type 2 mRNA is lower at the regressed stage than at the other stages
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epithelium
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of normotensive and hypertensive rats, the latter are hyperthrophied and fibrotic and have structural alterations in the coronary circulation, expression of isozymes 11beta-HSD1 and 11beta-HSD2, overview
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primary
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11beta-HSD2, but not 11beta-HSD1, is strongly expressed in LbetaT2 cells
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of neonatal pig. High expression of 11beta-hydroxysteroid dehydrogenase type 2 mRNA, resulting in oxidation from cortisol to cortison, with no detection of the reduction reaction. Activity of type 2 enzyme is higher than the oxidation activity of the type 1 enzyme
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peripheral lymph nodes and mesenteric lymph nodes
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lung epithelial cell line, isozymes HSD1 and HSD2
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expression and activity of isozyme 11beta-HSD2 in probes of seven different women with ovarian cancer of different types, overview
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high level of expression and activity
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highly expressed
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renal cortical collecting duct cell line
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mainly isozyme 11beta-HSD2, the concentration of isozyme 11beta-HSD1 is 10-100fold lower, expression analysis, isozyme 11beta-HSD2 shows strong expression and activity in quiescent cells
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at baseline, mRNA levels are similar in diabetic and control sugjects for 11beta-HSD1, 11beta-HSD2, and hexose-6-phosphate dehydrogenase. 11beta-HSD1 activity is reduced in diabetic subjects, while 11beta-HSD2 activity is increased. After application of dexamethasone, 11beta-HSD1 mRNA increases in both groups, whereas 11beta-HSD2 mRNA decreases. 11beta-HSD1 activity increases in diabetic subjects, but not in controls, whereas 11beta-HSD2 activity does not change in either group; mRNA levels are similar in diabetic and control subjects for 11beta-hydroxysteroid dehydrogenase 1 and 11beta-hydroxysteroid dehydrogenase 2. 11beta-Hydroxysteroid dehydrogenase 2-activity is higher in diabetic patients. After treatment with dexamethasone, 11beta-hydroxysteroid dehydrogenase 1-mRNA increases in both groups, whereas 11beta-hydroxysteroid dehydrogenase 2-mRNA decreases. 11beta-Hydroxysteroid dehydrogenase 1-activity increases in diabetic patients, but not in control, whereas 11beta-hydroxysteroid dehydrogenase 2-activity does not change in either group
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low levels of mRNA
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placental trophoblast cells
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isoform 11beta-HSD1 is clearly expressed while isoform 11beta-HSD2 is much less prominent, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth
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NAD+-dependent 11beta-hydroxysteroid dehydrogenase activity
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splanchnic activity
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high-fat fed animals overexpress 11beta-hydroxysteroid dehydrogenase type 2 in subcutaneous but not in retroperitoneal fat. Enzyme mRNA levels strongly correlate in both tissues with different parameters related to obesity, such as body weight, adiposity, and insulin resistance
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almost no expression and activity
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11beta-HSD2 in the adult brain is thought to protect mineralocorticoid receptors from inactivation by corticosterone
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11beta-HSD2 in the adult brain is thought to protect mineralocorticoid receptors from inactivation by corticosterone
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11HSD1 is highly expressed in various brain structures, including the hippocampus
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pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+
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colon epithelial cell line, isozyme HSD2
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pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+
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high level of expression and activity
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isoform 11beta-HSD1 is clearly expressed while isoform 11beta-HSD2 is much less prominent, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth
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isoform 11beta-HSD1 is clearly expressed while isoform 11beta-HSD2 is much less prominent, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth
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luteinizing granulosa cell
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of animals that received betamethasone as a fetus, or whose mothers received betamethasone during pregnancy. Adult animals demonstrate increased mineralocorticoid and 11beta-HSD2 mRNA levels
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cortex
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high level of expression and activity
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highly expressed
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similar amounts of protein for both isoform 11beta-HSD1 and 11beta-HSD2. 11beta-HSD1 functions as a dehydrogenase with no significant reverse reductase activity and colocalizes with cyclooxygenase COX-2 in proximal tubule cells. No colocalization of COX-2 with isoform 11beta-HSD2 in cortical collecting duct
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isozyme expression patterns, overview
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11betaHSD2 mRNA and protein expression increases significantly after treatment with estradiol; renal 11beta-HSD1 mRNA and protein expression decrease to very low levels after estradiol treatment
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hepatic artery, portal vein, and hepatic vein, local cortisol concentrations, overview
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almost no expression and activity
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adult and fetal, isozymes HSD1 and HSD2
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adult and fetal lung and cultured fetal lung explant contain similar amounts of isoform HSD2 mRNA. Higher levels of HSD2 protein are detected in fetal lung tissue than in adult lung, with expression being restricted to a subset of epithelial cells in the fetal lung tissue. Differentiated fetal lung explants express higher levels of enzyme protein than undifferentiated explants
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fetal, adult
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low level of expression and activity
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surface epithelium
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highly expressed
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constitutes an important barrier for 11-OH steroids during pregnancy between maternal and fetal organism, presence of two isoforms
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almost exclusively isozyme 11beta-HSD2
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the 11beta-HSD2 expression and activity is 7-8fold higher compared to 11beta-HSD1 in the chorionic plate of small gestational age placentas
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two forms present, one NAD-specific the other NADP+-dependent
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
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high level of expression and activity
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immature
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almost no expression and activity
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low levels of mRNA
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isozyme 11beta-HSD2
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isozyme expression analysis
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of neonatal pig
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pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
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additional information
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normotensive persons and patients with low renin hypertension, LREH, expression and activity of isozyme 11beta-HSD2
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additional information
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low expression in liver, ovary, prostate gland, and testis
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additional information
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isozyme 11beta-HSD1 expression is about 30% reduced in castrated male rats, while expression of isozyme 11beta-HSD2 is increased, overview
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additional information
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isozyme 11beta-HSD2 expression is highly reduced in proliferating cells
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additional information
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isozyme 11beta-HSD2activity and plasma corticosterone are determined in toads from pre- (PR), post- (P), and reproductive (R) periods, activity is highest in P period, overview
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