1.1.1.B40: 11beta-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 11beta-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

11 beta-hydroxysteroid dehydrogenase, 11 beta-hydroxysteroid dehydrogenase type 2, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, 11beta hydroxysteroid dehydrogenase type 2, 11beta-HSD, 11beta-HSD 2, 11beta-HSD type 2, 11beta-HSD1, 11beta-HSD2, 11beta-HSD2 (oxidase) NAD+, 11beta-HSD2/HSD11B2, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 2, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type-2, 11beta-hydroxysteroid dehydrogenases type 2, 11beta-OHSD, 11betaHSD2, 11HSD1, 7-alpha-HCD, 7-alpha-hydroxycholesterol dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 1, HSD 2, HSD11B type 1, HSD11B type 2, Hsd11B2, isozyme 11beta-HSD2, More, NAD(+)-dependent 11beta-dehydrogenase, NAD+-dependent 11beta-hydroxysteroid dehydrogenase 2, type 2 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+)

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Results	in table
8	Activating Compound
9	AA Sequence
9	Application
27	Cloned(Commentary)
68	Cofactor
1	Crystallization (Commentary)
448	Disease/ Diagnostics
4	Expression
11	General Information
127	IC50 Value
251	Inhibitors
57	Ki Value [mM]
37	KM Value [mM]
20	Localization
15	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
258	Organism
20	pH Optimum
1	pH Range
2	Purification (Commentary)
8	Reaction
3	Reaction Type
91	Reference
149	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
118	Substrates and Products (Substrate)
17	Subunits
119	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
1	Temperature Stability [°C]

IC50 Value

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IC50 Value on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00061 - 0.00105

(+)-gossypol

2 entries

0.00088 - 0.00105

(+/-)-gossypol

2 entries

0.00133 - 0.0019

(-)-gossypol

2 entries

0.0000049

(3alpha,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.00075

(3beta)-3-(acetyloxy)-11-oxoolean-12-en-30-oic acid

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.0000029

(3beta)-30-[hydroxy(methyl)amino]-11,30-dioxoolean-12-en-3-yl acetate

Homo sapiens

P80365

pH 7.4, 37°C

725817

0.000122

(3beta)-N,3-dihydroxy-11-oxoolean-12-en-30-amide

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.000458

(3beta,18beta,20beta)-3-(acetylamino)-11-oxo-olean-12-en-29-oic acid

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.0000611

(3beta,18beta,20beta)-3-acetoxy-N-hydroxy-11-oxo-olean-12-en-29-amide

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.0000029

(3beta,18beta,20beta)-3-acetoxy-N-methyl-N-hydroxy-11-oxoolean-12-en-29-amide

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.00213

(3beta,18beta,20beta)-3-hydroxy-N-methoxy-11-oxo-olean-12-en-29-amide

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.0000145

(3beta,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.000268

(3E)-3-(methoxyimino)-11-oxoolean-12-en-30-oic acid

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.0000069

(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-4,4,6a,6b,8a,11,14b-heptamethyl-11-[(methylsulfonyl)amino]-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl acetate

Homo sapiens

P80365

pH 7.4, 37°C

725817

0.00047

11-dehydrocortisterone

Ovis aries

-

pH 8.4, 37°C

670252

0.001

11-deoxycorticosterone

Ovis aries aries

-

IC50: 0.001 mM

285948

0.008

11-oxo-3beta,5alpha-tetrathydrotestosterone

Ovis aries

-

pH 8.4, 37°C

670252

0.0015

11-oxo-allopregnanolone

Ovis aries

-

pH 8.4, 37°C

670252

0.0004

11-oxo-progesterone

Ovis aries

-

pH 8.4, 37°C

670252

0.00135

11-oxo-testosterone

Ovis aries

-

pH 8.4, 37°C

670252

0.000061

11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione

Homo sapiens

-

i.e. cortisol, pH and temperature not specified in the publication

285949

0.0000051

11beta,21-dihydroxypregn-4-en-3,20-dione

Homo sapiens

-

pH and temperature not specified in the publication

285949

0.00012

11beta-hydroxy-allopregnanolone

Ovis aries

-

pH 8.4, 37°C

670252

0.0045

11beta-hydroxyandrostanediol

Ovis aries

-

pH 8.4, 37°C

670252

0.0078

11beta-hydroxyandrostenedione

Ovis aries

-

pH 8.4, 37°C

670252

0.00005

11beta-hydroxyprogesterone

Ovis aries

-

pH 8.4, 37°C

670252

0.00035

11beta-hydroxytestosterone

Ovis aries

-

pH 8.4, 37°C

670252

0.000257

18beta-glycyrrhetinic acid

Homo sapiens

-

37°C, pH not specified in the publication

699842

0.000329

3,11-dioxoolean-12-en-30-oic acid

Homo sapiens

-

pH not specified in the publication, 37°C

711471

5.6

3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate

Homo sapiens

-

pH and temperature not specified in the publication

285951

0.0008

3alpha,5alpha-tetrahydro-dehydrocortisterone

Ovis aries

-

pH 8.4, 37°C

670252

0.0005

3alpha,5alpha-tetrahydroaldosterone

Ovis aries

-

pH 8.4, 37°C

670252

0.00026

3alpha,5alpha-tetrahydrocorticosterone

Ovis aries

-

pH 8.4, 37°C

670252

0.008

3alpha,5alpha-tetrahydrocortisol

Ovis aries

-

pH 8.4, 37°C

670252

0.000097 - 0.254

3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid

2 entries

0.0235

4-n-octylphenol

Homo sapiens

-

inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C

668432

0.0203

4-nonylphenol

Homo sapiens

-

inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C

668432

0.00035

4-pregnen-11,17-diol-3,20-dione

Ovis aries aries

-

IC50: 0.00035 mM

285948

0.0001

4-pregnen-11alpha-ol-3,20-dione

Ovis aries aries

-

IC50: 0.0001 mM

285948

0.00005

4-pregnen-11beta-ol-3,20-dione

Ovis aries aries

-

IC50: 0.00005 mM

285948

0.047

4-pregnen-17alpha-ol-3,20-dione

Ovis aries aries

-

IC50: 0.047 mM

285948

0.007

4-pregnen-20alpha-ol-3-one

Ovis aries aries

-

IC50: 0.007 mM

285948

0.008

4-pregnen-20beta-ol-3-one

Ovis aries aries

-

IC50: 0.008 mM

285948

0.001

4-pregnen-21-ol-3,20-dione

Ovis aries aries

-

IC50: 0.001 mM

285948

0.0004

4-pregnen-3,11,20-trione

Ovis aries aries

-

IC50: 0.0004 mM

285948

0.0011

4-pregnen-3,20-dione

Ovis aries aries

-

IC50: 0.0011 mM

285948

0.0089

4-t-octylphenol

Homo sapiens

-

inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C

668432

0.0001

5-pregnen-3beta,11beta-diol-20-one

Ovis aries aries

-

IC50: 0.0001 mM

285948

0.00015

5alpha-dihydrocorticosterone

Ovis aries

-

pH 8.4, 37°C

670252

0.00035

5alpha-pregnan-11alpha-ol-3,20-dione

Ovis aries aries

-

IC50: 0.00035 mM

285948

0.0031

5alpha-pregnan-11beta,17alpha,21-triol-3,20-dione

Ovis aries aries

-

IC50: 0.0031 mM

285948

0.00015

5alpha-pregnan-11beta,21-diol-3,20-dione

Ovis aries aries

-

IC50: 0.00015 mM

285948

0.008

5alpha-pregnan-3alpha,11beta,17alpha,21-tetrol-20-one

Ovis aries aries

-

IC50: 0.008 mM

285948

0.00026

5alpha-pregnan-3alpha,11beta,21-triol-20-one

Ovis aries aries

-

IC50: 0.00026 mM

285948

0.00012

5alpha-pregnan-3alpha,11beta-diol-20-one

Ovis aries aries

-

IC50: 0.00012 mM

285948

0.0055

5alpha-pregnan-3alpha,17alpha,21-triol-11,20-dione

Ovis aries aries

-

IC50: 0.0055 mM

285948

0.0008

5alpha-pregnan-3alpha,21-diol-11,20-dione

Ovis aries aries

-

IC50: 0.0008 mM

285948

0.0024

5alpha-Pregnan-3alpha,21-diol-20-one

Ovis aries aries

-

IC50: 0.0024 mM

285948

0.008

5alpha-pregnan-3alpha-ol-20-one

Ovis aries aries

-

IC50: 0.008 mM

285948

0.00002 - 0.00005

carbenoxolone

2 entries

0.513

chenodeoxycholic acid

Cavia porcellus

-

IC50: 0.513 mM

285954

3.529

cholic acid

Cavia porcellus

-

IC50: 3.529 mM

285954

0.0089

dexamethasone

Homo sapiens

-

pH and temperature not specified in the publication

285949

0.01369

di-n-butyl phthalate

Rattus norvegicus

-

-

697286

0.03264 - 0.0465

dicyclohexyl phthalate

2 entries

0.08559

dipropyl phthalate

Rattus norvegicus

-

-

697286

0.452

Ethacrynic acid

Cavia porcellus

-

IC50: 0.452 mM

285954

0.059

Furosemide

Cavia porcellus

-

IC50: 0.059 mM, competitive

285954

0.0000024 - 0.000257

glycyrrhetinic acid

2 entries

0.00000071

glycyrrhizinic acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

713232

0.00000071

glycyrrhizininc acid

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

711737

0.1108 - 0.1218

mono (2-ethylhexyl) phthalate

2 entries

0.0168 - 0.3279

mono-(2-ethylhexyl) phthalate

2 entries

0.336

naringenin

Cavia porcellus

-

IC50: 0.336 mM

285954

2.373

naringin

Cavia porcellus

-

IC50: 2.373 mM

285954

0.000048 - 0.000293

perfluorooctane sulfonate

2 entries

1.358

Phenylbutazone

Cavia porcellus

-

IC50: 1.358 mM

285954

1.395

sistosterol

Cavia porcellus

-

IC50: 1.395 mM

285954

0.01

sterenin A

Homo sapiens

-

value above, pH not specified in the publication, 26°C

687328

0.01

sterenin B

Homo sapiens

-

value above, pH not specified in the publication, 26°C

687328

0.01

sterenin C

Homo sapiens

-

value above, pH not specified in the publication, 26°C

687328

0.01

sterenin D

Homo sapiens

-

value above, pH not specified in the publication, 26°C

687328

1.968

stigmasterol

Cavia porcellus

-

IC50: 1.968 mM

285954

0.0165

tributyltin

Homo sapiens

-

inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C

668432

0.0033

Triphenyltin

Homo sapiens

-

inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C

668432

additional information

(1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol

32 entries

0.00061

(+)-gossypol

Rattus norvegicus

-

pH and temperature not specified in the publication

699841

0.00105

(+)-gossypol

Homo sapiens

-

pH and temperature not specified in the publication

699841

0.00088

(+/-)-gossypol

Rattus norvegicus

-

pH and temperature not specified in the publication

699841

0.00105

(+/-)-gossypol

Homo sapiens

-

pH and temperature not specified in the publication

699841

0.00133

(-)-gossypol

Rattus norvegicus

-

pH and temperature not specified in the publication

699841

0.0019

(-)-gossypol

Homo sapiens

-

pH and temperature not specified in the publication

699841

0.000097

3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid

Homo sapiens

-

pH and temperature not specified in the publication

285951

0.254

3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid

Cavia porcellus

-

IC50: 0.254 mM

285954

0.00002

carbenoxolone

Homo sapiens

-

pH and temperature not specified in the publication

699841

0.00005

carbenoxolone

Rattus norvegicus

-

pH and temperature not specified in the publication

699841

0.03264

dicyclohexyl phthalate

Rattus norvegicus

-

-

697286

0.0465

dicyclohexyl phthalate

Homo sapiens

-

inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C

668432

0.0000024

glycyrrhetinic acid

Homo sapiens

-

cell-based assay, pH not specified in the publication, temperature not specified in the publication

711694

0.000257

glycyrrhetinic acid

Homo sapiens

-

pH not specified in the publication, 37°C

711471

0.1108

mono (2-ethylhexyl) phthalate

Homo sapiens

-

-

697286

0.1218

mono (2-ethylhexyl) phthalate

Rattus norvegicus

-

-

697286

0.0168

mono-(2-ethylhexyl) phthalate

Mus musculus

-

11beta-HSD2 from LbetaT2 cell microsomes, in PBS (pH 7.4), at 37°C

696054

0.3279

mono-(2-ethylhexyl) phthalate

Mus musculus

-

11beta-HSD2 from kidney microsomes, in PBS (pH 7.4), at 37°C

696054

0.000048

perfluorooctane sulfonate

Homo sapiens

P80365

pH 7.2, 37°C

725818

0.000293

perfluorooctane sulfonate

Rattus norvegicus

-

pH 7.2, 37°C

725818

additional information

(1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol

Homo sapiens

-

IC50 = 0.0254 mg/ml, pH not specified in the publication, temperature not specified in the publication

713232

additional information

(1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aR,6S,8aR)-6-hydroxy-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol

Homo sapiens

-

IC50 above 0.1 mg/ml, pH not specified in the publication, temperature not specified in the publication

713232

additional information

(1S,2R,5R,6R)-4-(hydroxymethyl)-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol

Homo sapiens

-

IC50 = 0.0015 mg/ml, pH not specified in the publication, temperature not specified in the publication

713232

additional information

(2E,4S)-4-hydroxy-5-[(1S,5S,6S)-6-(hydroxymethyl)-2-methylidenebicyclo[3.1.1]hept-6-yl]-2-methylpent-2-enoic acid

Homo sapiens

-

IC50 = 0.0106 mg/ml, pH not specified in the publication, temperature not specified in the publication

713232

additional information

(2S)-5-(acetyloxy)-2-hydroxypentyl acetate

Homo sapiens

-

IC50 = 0.177 mg/ml, pH not specified in the publication, temperature not specified in the publication

712257

additional information

(3alpha,18beta,20beta)-11-oxo-3-trifluoromethylsulfonylaminoolean-12-en-29-oic acid

Homo sapiens

-

50% residual activity at 0,0002 mM, pH not specified in the publication, 37°C

711471

additional information

(3alpha,18beta,20beta)-3-(acetylamino)-11-oxo-olean-12-en-29-oicacid

Homo sapiens

-

4% residual activity at 0,001 mM, pH not specified in the publication, 37°C

711471

additional information

(3alpha,18beta,20beta)-3-methylsulfonylamino-11-oxo-olean-12-en-29-oic acid

Homo sapiens

-

4% residual activity at 0,0002 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta)-3-hydroxy-11-oxoolean-12-en-30-amide

Homo sapiens

-

13% residual activity at 0,001 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-11-oxo-3-succinylamino-olean-12-en-29-oic acid

Homo sapiens

-

13% residual activity at 0,001 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-11-oxo-3-trifluoromethylsulfonylaminoolean-12-en-29-oic acid

Homo sapiens

-

22% residual activity at 0,0002 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-3,N-dihydroxy-N-methyl-11-oxo-olean-12-en-29-amide

Homo sapiens

-

7% residual activity at 0,0002 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-3-(2-carboxy-ethylsulfonylamino)-11-oxoolean-12-en-29-oic acid

Homo sapiens

-

40% residual activity at 0,001 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-3-(2-methoxycarbonyl-ethylsulfonylamino)-11-oxo-olean-12-en-29-oic acid

Homo sapiens

-

3% residual activity at 0,001 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-3-acetoxy-N-methoxy-11-oxo-olean-12-en-29-amide

Homo sapiens

-

36% residual activity at 0,001 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-3-acetylamino-N-hydroxy-N-methyl-11-oxoolean-12-en-29-amide

Homo sapiens

-

4% residual activity at 0,0002 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-3-amino-11-oxoolean-12-en-29-oic acid, diphenylmethyl ester

Homo sapiens

-

42% residual activity at 0,001 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-3-methylsulfonylamino-11-oxo-olean-12-en-29-oic acid

Homo sapiens

-

4% residual activity at 0,0002 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-N-hydroxy-N-methyl-11-oxo-3-[(trifluoromethylsulfonyl)amino]-olean-12-en-29-amide

Homo sapiens

-

44% residual activity at 0,0002 mM, pH not specified in the publication, 37°C

711471

additional information

(3beta,18beta,20beta)-N-hydroxy-N-methyl-3-methoxyamino-11-oxo-olean-12-en-29-amide

Homo sapiens

-

30% residual activity at 0,0002 mM, pH not specified in the publication, 37°C

711471

additional information

(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol

Homo sapiens

-

IC50 = 0.177 mg/ml, pH not specified in the publication, temperature not specified in the publication

711737

additional information

(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol

Mus musculus

-

IC50 = 0.2505 mg/ml, pH not specified in the publication, temperature not specified in the publication

711737

additional information

(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol

Homo sapiens

-

IC50 = 0.22 mg/ml, pH not specified in the publication, temperature not specified in the publication

711737

additional information

(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol

Mus musculus

-

IC50 = 0.3303 mg/ml, pH not specified in the publication, temperature not specified in the publication

711737

additional information

(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one

Homo sapiens

-

IC50 = 0.2 mg/ml, pH not specified in the publication, temperature not specified in the publication

711737

additional information

(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one

Mus musculus

-

IC50 = 0.5002 mg/ml, pH not specified in the publication, temperature not specified in the publication

711737

additional information

2-oxopentane-1,5-diyl diacetate

Homo sapiens

-

IC50 = 0.0051 mg/ml, pH not specified in the publication, temperature not specified in the publication

712257

additional information

2-oxopentane-1,5-diyl diacetate

Mus musculus

-

IC50 = 0.0323 mg/ml, pH not specified in the publication, temperature not specified in the publication

712257

additional information

5-hydroxy-4-oxopentyl acetate

Homo sapiens

-

IC50 = 0.0389 mg/ml, pH not specified in the publication, temperature not specified in the publication

712257

additional information

5-hydroxy-4-oxopentyl acetate

Mus musculus

-

IC50 = 0.1291 mg/ml, pH not specified in the publication, temperature not specified in the publication

712257

additional information

BVT-14225

Homo sapiens

-

isozyme 11beta-HSD1 IC50: 52 nM, 1000fold less potent against isozyme 11beta-HSD2

667956

additional information

carbenoxolone

Homo sapiens

-

2% residual activity at 0,001 mM, pH not specified in the publication, 37°C

711471