1.1.1.B38: hydroxymethylglutaryl-CoA reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase [NAD(P)H], go to the full flat file.

Reaction

Synonyms

3-hydroxy-3-methylglutaryl coenzyme A reductase, AF1736, class II HMG-CoA reductase, HGMR, HMG-CoA reductase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.B38 hydroxymethylglutaryl-CoA reductase [NAD(P)H]

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Results	in table
1	AA Sequence
2	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
1	General Information
1	IC50 Value
1	Inhibitors
6	kcat/KM [mM/s]
7	KM Value [mM]
2	Natural Substrates/ Products (Substrates)
2	Organism
2	Pathway
4	pH Optimum
2	Purification (Commentary)
1	Reaction
2	Reference
4	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.1.1.B38 - hydroxymethylglutaryl-CoA reductase [NAD(P)H]

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+

mevalonate + CoA + 2 NAD+

Streptococcus pneumoniae

-

-

760596

-

-

?

3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

mevalonate + CoA + 2 NADP+

Streptococcus pneumoniae

-

-

760596

-

-

?

mevalonate + CoA + 2 NAD+

3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+

Archaeoglobus fulgidus

O28538

optimal activity using NADP(H) occurs at pH from 1 to 3 units more acidic than that observed using NAD(H)

723732

-

-

r

mevalonate + CoA + 2 NADP+

3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

Archaeoglobus fulgidus

O28538

slight preference for NAD(H) versus NADP(H). Optimal activity using NADP(H) occurs at a pH from 1 to 3 units more acidic than that observed using NAD(H)

723732

-

-

r