Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.004 - 0.507
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
82
(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid
-
pH 8.5, 37°C, with cofactor NAD+
0.115
(5beta,20R)-20-hydroxypregnan-3-one
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.13 - 0.59
1-Acenaphthenol
2.2
2-decalol
pH 10.5, 25°C
0.0833 - 0.183
3alpha-adiol
0.008
3alpha-androstanediol
-
pH 7.0, 25°C, recombinant enzyme
0.000016 - 0.012
3alpha-hydroxytibolone
0.000016 - 0.016
3beta-hydroxytibolone
1.08
4-nitrobenzaldehyde
-
-
0.0023 - 0.0735
4-pregnen-3alpha,20beta-diol
0.42
5alpha-androstane-3,17-dione
-
pH 7.0, 25, reduction reaction
0.003 - 0.04
5alpha-dihydroprogesterone
0.0038 - 1
5alpha-dihydrotestosterone
0.047
5beta-androstane-3,17-dione
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.0167 - 0.05
5beta-dihydroprogesterone
0.105
5beta-pregnane-3,20-dione
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.1
6-tert-butyl-2,3-epoxy-4-hydroxy-5-cyclohexen-1-one
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.183 - 18.9
9,10-phenanthrenequinone
0.00017
allopregnanolone
-
pH 7.0, 25°C
1.9
androstanedione
-
detection spectrophotometrically
230
androstenol
pH 10.5, 25°C
0.0018 - 500
androsterone
0.015 - 0.05
benzenedihydrodiol
76
chenodeoxycholic acid
-
pH 8.5, 37°C, with cofactor NAD+
2.5
Cyclohexanol
pH 10.5, 25°C
0.022
Dehydrolithocholic acid
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.167
diacetyl
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
77
glycocholic acid
-
pH 8.5, 37°C, with cofactor NAD+
0.283
isatin
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
72
lithocholic acid
-
pH 8.5, 37°C, with cofactor NAD+
0.00017
NADP+
-
pH 7.0, 25°C
0.003
NADPH
-
pH 7.0, 25°C
0.14
oxidized 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one
-
isozyme AKR1C3
0.0035 - 0.0392
pregn-4-en-3,20-dione
74
taurocholic acid
-
pH 8.5, 37°C, with cofactor NAD+
additional information
additional information
-
0.004
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
-
pH 7.0, 37°C with NADP+
0.0167
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
-
pH 7.0, 37°C with NAD+
0.203
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
-
detection spectrophotometrically
0.32
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
-
detection radiometrically
0.507
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
-
detection fluorometrically
0.13
1-Acenaphthenol
-
pH 7.4, 25°C, recombinant isozyme AKR1C4
0.42
1-Acenaphthenol
-
pH 7.4, 25°C, recombinant isozyme AKR1C3
0.49
1-Acenaphthenol
-
pH 7.4, 25°C, recombinant isozyme AKR1C1
0.59
1-Acenaphthenol
-
pH 7.4, 25°C, recombinant isozyme AKR1C2
0.09
1-Indanol
-
pH 7.4, 25°C, recombinant isozyme AKR1C3
0.158
1-Indanol
-
pH 7.4, 25°C, recombinant isozyme AKR1C4
0.163
1-Indanol
-
pH 7.4, 25°C, recombinant isozyme AKR1C2
0.21
1-Indanol
-
pH 7.4, 25°C, recombinant isozyme AKR1C1
0.0833
3alpha-adiol
-
-
0.000016
3alpha-hydroxytibolone
below, pH 7.0, 37°, isozymes AKR1C1 and AKR1C3
0.012
3alpha-hydroxytibolone
pH 7.0, 37°, isozyme AKR1C4
0.000016
3beta-hydroxytibolone
below, pH 7.0, 37°, isozyme AKR1C3
0.0005
3beta-hydroxytibolone
pH 7.0, 37°, isozyme AKR1C1
0.004
3beta-hydroxytibolone
pH 7.0, 37°, isozyme AKR1C4
0.016
3beta-hydroxytibolone
pH 7.0, 37°, isozyme AKR1C1
0.0023
4-pregnen-3alpha,20beta-diol
pH 7.0, 25°C, isozyme AKR1C3
0.0025
4-pregnen-3alpha,20beta-diol
pH 7.0, 25°C, isozyme AKR1C1
0.046
4-pregnen-3alpha,20beta-diol
pH 7.0, 25°C, isozyme AKR1C2
0.0735
4-pregnen-3alpha,20beta-diol
pH 7.0, 25°C, isozyme AKR1C4
0.003
5alpha-dihydroprogesterone
-
pH 7.0, 25°C
0.004
5alpha-dihydroprogesterone
-
isozyme AKR1C3
0.008
5alpha-dihydroprogesterone
-
pH 7.0, 25°C, isozyme AKR1C2
0.04
5alpha-dihydroprogesterone
-
pH 7.0, 25°C, isozyme AKR1C1
0.0038
5alpha-dihydrotestosterone
-
pH 7.0, 37°C, with NAD(P)H
0.02
5alpha-dihydrotestosterone
-
isozyme AKR1C2
0.033
5alpha-dihydrotestosterone
-
pH 7.0, 25°C, recombinant enzyme
0.0398
5alpha-dihydrotestosterone
-
detection fluorometrically
0.0612
5alpha-dihydrotestosterone
pH 7.4, 37°C, recombinant wild-type enzyme
0.0965
5alpha-dihydrotestosterone
-
detection spectrophotometrically
0.114
5alpha-dihydrotestosterone
-
detection radiometrically
0.1153
5alpha-dihydrotestosterone
pH 7.4, 37°C, recombinant mutant V54L
1
5alpha-dihydrotestosterone
-
isozyme AKR1C9
0.0167
5beta-dihydroprogesterone
-
pH 7.0, 37°C
0.018
5beta-dihydroprogesterone
-
pH 7.0, 25°C, isozyme AKR1C2
0.05
5beta-dihydroprogesterone
-
pH 7.0, 25°C, isozyme AKR1C1
0.183
9,10-phenanthrenequinone
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
18.9
9,10-phenanthrenequinone
-
-
0.0018
androsterone
-
pH 7.4, 25°C, recombinant isozyme AKR1C4
0.0028
androsterone
-
pH 9.0, 25°C, recombinant His-tagged mutant S114A/Y155F
0.003
androsterone
-
pH 9.0, 25°C, recombinant His-tagged mutant Y155F/K159A
0.007
androsterone
-
pH 7.4, 25°C, recombinant isozyme AKR1C2
0.12
androsterone
-
pH 9.0, 25°C, recombinant His-tagged mutant S114A
0.444 - 2.6
androsterone
-
-
0.82
androsterone
-
pH 7.0, 25, oxidation reaction
1.5
androsterone
-
pH 9.0, 25°C, recombinant His-tagged mutant Y155F
18.9
androsterone
-
pH 9.0, 25°C, recombinant His-tagged mutant K159A
134
androsterone
-
pH 8.5, 37°C, with cofactor NAD+
318
androsterone
-
pH 9.0, 25°C, recombinant His-tagged wild-type
500
androsterone
pH 10.5, 25°C
0.015
benzenedihydrodiol
-
pH 7.4, 25°C, recombinant isozyme AKR1C3
0.02
benzenedihydrodiol
-
pH 7.4, 25°C, recombinant isozyme AKR1C2
0.03
benzenedihydrodiol
-
pH 7.4, 25°C, recombinant isozyme AKR1C4
0.05
benzenedihydrodiol
-
pH 7.4, 25°C, recombinant isozyme AKR1C1
0.045
cholate
37°C, pH 8.0, mutant enzyme K157A
0.12
cholate
37°C, pH 8.0, mutant enzyme S114A/Y153F
0.62
cholate
37°C, pH 8.0, mutant enzyme Y153F
0.8
cholate
37°C, pH 8.0, mutant enzyme S114A
23
cholate
37°C, pH 8.0, wild-type enzyme
35
cholic acid
-
pH 8.5, 37°C, with cofactor thio-NAD+
75
cholic acid
-
pH 8.5, 37°C, with cofactor NAD+
0.89
dehydrocholate
37°C, pH 8.0, mutant enzyme S114A
1.1
dehydrocholate
37°C, pH 8.0, mutant enzyme Y153F
48
dehydrocholate
37°C, pH 8.0, wild-type enzyme
23
Fusidic acid
-
pH 8.5, 37°C, with cofactor NAD+
25
Fusidic acid
-
pH 8.5, 37°C, with cofactor thio-NAD+
0.02
NADH
mutant S114A, pH 7.5, 25°C
63
NADH
wild-type, pH 7.5, 25°C
0.0035
pregn-4-en-3,20-dione
pH 7.4, 37°C, recombinant wild-type enzyme
0.0392
pregn-4-en-3,20-dione
pH 7.4, 37°C, recombinant mutant V54L
additional information
additional information
-
overview, values for various substrates and 6 different isozymes
-
additional information
additional information
-
cofactor kinetics of wild-type and mutant enzymes, overview
-