1.1.1.50: 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

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For detailed information about 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific), go to the full flat file.

Reaction

Synonyms

3 alpha-hydroxysteroid dehydrogenase, 3 alphaHD, 3-alpha hydroxysteroid dehydrogenase type 3, 3-alpha-HSD, 3alpha-HSD, 3alpha-HSD/CR, 3alpha-HSD3, 3alpha-HSOR, 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase type 3, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido-reductase, 3alpha-hydroxysteroid oxidoreductase, 3alpha-hydroxysteroid-5beta-oxidoreductase, 3alpha-OR, 3alpha-oxidoreductase, 3alpha/3beta-hydroxysteroid dehydrogenase, 3alphaHSD, 3HSD, 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, AKR1C, AKR1C1, AKR1C1-4, AKR1C14, AKR1C17, AKR1C2, AKR1C3, AKR1C4, AKR1C9, aldo-keto reductase 1C2, bile-acid binding protein, chlordecone reductase, DD2, DD21, dihydrodiol dehydrogenase, HSD, HSD28, HSD29, hsdA, HSDH, hydroxyprostaglandin dehydrogenase, More, NAD(P)+-3alpha-hydroxysteroid dehydrogenase, NAD+-dependent 3alpha-HSD, NADP(H)-dependent 3alpha-HSD, NADPH:5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, prostaglandin F2alpha-synthase, Ps3alphaHSD, PT3HSD, sterognost 3alpha dehydrogenase, 3alpha-hydroxy steroid, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3alpha-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase, type I 3alpha-HSD

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

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Results	in table
8	Activating Compound
395	AA Sequence
9	Application
1	CAS Registry Number
42	Cloned(Commentary)
103	Cofactor
12	Crystallization (Commentary)
170	Disease/ Diagnostics
3	Expression
12	General Information
5	General Stability
13	IC50 Value
110	Inhibitors
8	kcat/KM [mM/s]
26	Ki Value [mM]
182	KM Value [mM]
47	Localization
6	Metals/Ions
37	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
114	Organism
4	Pathway
12	PDB ID
34	pH Optimum
5	pH Range
2	pH Stability
56	Protein Variants
38	Purification (Commentary)
17	Reaction
3	Reaction Type
100	Reference
1	Renatured (Commentary)
112	Source Tissue
65	Specific Activity [micromol/min/mg]
9	Storage Stability
347	Substrates and Products (Substrate)
33	Subunits
168	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
3	Temperature Range [°C]
10	Temperature Stability [°C]
105	Turnover Number [1/s]

Temperature Range

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Temperature Range on EC 1.1.1.50 - 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

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TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

15 - 45

Pseudomonas aeruginosa

Q9I1X3

optimum at 30°C, over 60% of maximal activity in the range of 25-45°C, with the temperature increasing from 30°C to 45°C, the enzyme activity gradually decreases to 77.55% of the optimum whereas with the temperature decreasing from 30°C to 15°C, the enzyme activity rapidly drops to 39.4% of the optimum

741361

16 - 36

Mus musculus

-

increase of activity over range

389527

28 - 46

Pseudomonas sp.

-

-

389552