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1.1.1.44: phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

This is an abbreviated version!
For detailed information about phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), go to the full flat file.

Word Map on EC 1.1.1.44

Reaction

6-phospho-D-gluconate
+
NADP+
=
D-ribulose 5-phosphate
 +
CO2
 +
NADPH
 +
H+

Synonyms

6-GPD, 6-P-gluconate dehydrogenase, 6-Pgd, 6-PGDH, 6-PGDHase, 6-phospho-D-gluconate dehydrogenase, 6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), 6-phosphogluconate dehydrogenase 1, 6-phosphogluconate dehydrogenase Gnd1, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate-dehydrogenase, 6-phosphogluconate:NADP oxidoreductase, 6-phosphogluconic carboxylase, 6-phosphogluconic dehydrogenase, 6-phosphonogluconate dehydrogenase, 6PDH, 6PG DH, 6PGD, 6PGDH, 6PGDH/Gnd1, 6PGDH1, 6PGDH2, 6PGDH3, At1G64190, At3g02360, At5g41670, D-gluconate-6-phosphate dehydrogenase, GCG1, gnd, GND1, Gnd1p, Gnd2p, GNTZII, LlPDH, Moth_1283, Os6PGDH1, Os6PGDH2, p6PGDH, peroxisomal 6-phosphogluconate dehydrogenase, Pgd, PGD1, PGD2, PGD3, phosphogluconic acid dehydrogenase, TM0438, YpjI, zwf3

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

Specific Activity

Specific Activity on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0169
-
unpurified enzyme, at pH 8.0 and 28°C
0.017
-
unpurified enzyme, at pH 8.0 and 25°C
0.025
activity of 6-phosphogluconate dhydrogenase in Corynebacterium glutamicum (ATCC 13032) culture in MCGC medium at 37°C, supplemented with glucoronate
0.032
-
supernantant
0.094
activity of 6-phosphogluconate dhydrogenase in Corynebacterium glutamicum (ATCC 13032) culture in MCGC medium at 37°C, supplemented with 0.5% fructose
0.1207
-
kidney enzyme, optimum conditions, pH 8.0, 37°C
0.152
activity of 6-phosphogluconate dhydrogenase expressed in transformed Escherichia coli mutants, supplemented with 0.5% fructose as carbon source
0.177
-
homogenate
0.291
activity of 6-phosphogluconate dhydrogenase in Corynebacterium glutamicum (ATCC 13032) culture in MCGC medium at 37°C, supplemented with 0.5% gluconate
0.41
-
-
0.4242
-
liver enzyme, optimum conditions, pH 8.0, 37°C
1.33
-
-
12
-
total enzyme after gel filtration in presence of 6-phosphogluconate
13.5
-
after 799fold purification, at pH 8.0 and 28°C
15.12
-
after 473fold purification
17.4
-
-
175
-
cell-free extract
18.7
-
ultrafiltration
19
-
pure enzyme
21.2
-
-
22
-
150fold purification
25.75
-
-
33.5
-
total enzyme after gel filtration in absence of 6-phosphogluconate
4.7
-
recombinant enzyme
5.259
-
after 309fold purification, at pH 8.0 and 25°C
5.7
pH 8.0, 25°C, mutant enzyme W104L
61
-
after 344fold purification
8
pH 8.0, 25°C, wild-type enzyme
80
-
pH 7.5, 25°C
92.3
-
-
additional information