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1.1.1.44: phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

This is an abbreviated version!
For detailed information about phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), go to the full flat file.

Word Map on EC 1.1.1.44

Reaction

6-phospho-D-gluconate
+
NADP+
=
D-ribulose 5-phosphate
+
CO2
+
NADPH
+
H+

Synonyms

6-GPD, 6-P-gluconate dehydrogenase, 6-Pgd, 6-PGDH, 6-PGDHase, 6-phospho-D-gluconate dehydrogenase, 6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), 6-phosphogluconate dehydrogenase 1, 6-phosphogluconate dehydrogenase Gnd1, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate-dehydrogenase, 6-phosphogluconate:NADP oxidoreductase, 6-phosphogluconic carboxylase, 6-phosphogluconic dehydrogenase, 6-phosphonogluconate dehydrogenase, 6PDH, 6PG DH, 6PGD, 6PGDH, 6PGDH/Gnd1, 6PGDH1, 6PGDH2, 6PGDH3, At1G64190, At3g02360, At5g41670, D-gluconate-6-phosphate dehydrogenase, GCG1, gnd, GND1, Gnd1p, Gnd2p, GNTZII, LlPDH, Moth_1283, Os6PGDH1, Os6PGDH2, p6PGDH, peroxisomal 6-phosphogluconate dehydrogenase, Pgd, PGD1, PGD2, PGD3, phosphogluconic acid dehydrogenase, TM0438, YpjI, zwf3

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

Source Tissue

Source Tissue on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
low activity in female and male rats, constant at age 2 months to age 9 months
Manually annotated by BRENDA team
-
high activity in female and male rats, decreasing from age 2 months to age 9 months
Manually annotated by BRENDA team
infected with the lentivirus expressing Flag tagged 6PGD (Flag-6PGD)
Manually annotated by BRENDA team
high enzyme expression level
Manually annotated by BRENDA team
highest activity in outer leaf sheaths and lowest in inner leaf sheaths
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
from spleen, lymph node or thymus
Manually annotated by BRENDA team
the enzyme is upregulated during salt stress
Manually annotated by BRENDA team
-
antibodies to 6-phosphogluconate dehydrogenase, decarboxylating are present in serum samples of ASA-positive (antisperm antibodies) infertile men
Manually annotated by BRENDA team
stably expressing epidermal growth factor receptor (EGFR), infected with the lentivirus expressing Flag tagged 6PGD (Flag-6PGD)
Manually annotated by BRENDA team
-
moderate activity in female and male rats, decreasing from age 2 months to age 9 months
Manually annotated by BRENDA team
additional information
-
enzyme mRNA concentration show age- and sex-related differences, especially in the liver, overview
Manually annotated by BRENDA team