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1.1.1.382: ketol-acid reductoisomerase (NAD+)

This is an abbreviated version!
For detailed information about ketol-acid reductoisomerase (NAD+), go to the full flat file.

Reaction

(2R)-2,3-dihydroxy-3-methylbutanoate
+
NAD+
=
(2S)-2-hydroxy-2-methyl-3-oxobutanoate
+
NADH
+
H+

Synonyms

ilvC

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.382 ketol-acid reductoisomerase (NAD+)

Reference

Reference on EC 1.1.1.382 - ketol-acid reductoisomerase (NAD+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cahn, J.K.; Brinkmann-Chen, S.; Spatzal, T.; Wiig, J.A.; Buller, A.R.; Einsle, O.; Hu, Y.; Ribbe, M.W.; Arnold, F.H.
Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases
Biochem. J.
468
475-484
2015
Alicyclobacillus acidocaldarius subsp. acidocaldarius (C8WR67), Ignisphaera aggregans (E0SRA9), uncultured archaeon (Q64BR7), uncultured archaeon GZfos26G2 (Q64BR7), Ignisphaera aggregans DSM 17230 (E0SRA9)
Manually annotated by BRENDA team
Brinkmann-Chen, S.; Cahn, J.K.; Arnold, F.H.
Uncovering rare NADH-preferring ketol-acid reductoisomerases
Metab. Eng.
26C
17-22
2014
Thermacetogenium phaeum, uncultured archaeon, Desulfosudis oleivorans, Archaeoglobus fulgidus (O28294)
Manually annotated by BRENDA team