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1.1.1.309: phosphonoacetaldehyde reductase (NADH)

This is an abbreviated version!
For detailed information about phosphonoacetaldehyde reductase (NADH), go to the full flat file.

Reaction

2-hydroxyethylphosphonate
+
NAD+
=
phosphonoacetaldehyde
+
NADH
+
H+

Synonyms

PhpC

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.309 phosphonoacetaldehyde reductase (NADH)

Substrates Products

Substrates Products on EC 1.1.1.309 - phosphonoacetaldehyde reductase (NADH)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-hydroxyethylphosphonate + NAD+
phosphonoacetaldehyde + NADH + H+
show the reaction diagram
-
the catalytic efficiency of phosphonoacetaldehyde reduction is 377fold greater than that of the reverse reaction, and even at pH 9.0, the catalytic efficiency of the forward reaction is still 11fold greater than that of the reverse reaction
-
-
r
phosphonoacetaldehyde + NADH + H+
2-hydroxyethylphosphonate + NAD+
show the reaction diagram
phosphonoacetaldehyde + NADPH + H+
2-hydroxyethylphosphonate + NADP+
show the reaction diagram
-
the reaction proceeds to apparent completion in the presence of NADH, but to a lesser extent with NADPH, which suggests that NADH is the preferred cofactor
-
-
?
additional information
?
-
-
no reaction is observed with hydroxymethylphosphonate and 3-hydroxypropylphosphonate
-
-
?