1.1.1.300: NADP-retinol dehydrogenase

This is an abbreviated version!
For detailed information about NADP-retinol dehydrogenase, go to the full flat file.

Reaction

Synonyms

aldehyde dehydrogenase, ALDH, all-trans retinal reductase, all-trans-retinaldehyde reductase, all-trans-retinol dehydrogenase, CG2065, CG2070, CG30491, CG3842, DHRS3, EC 5.2.1.3, hRDH5, hRoDH, More, mouse RDH11, mRDH11, NADP(H)-dependent retinol dehydrogenase/reductase, NADP+-dependent all-trans-retinol dehydrogenase, NADPH-dependent retinal reductase, NDRD, NRDR, NRDRA1, NRDRB1, NRDRB2, peroxisomal NADP(H)-dependent retinol dehydrogenase-reductase, photoreceptor retinol dehydrogenase, photoreceptor-associated retinol dehydrogenase, photoreceptor-specific retinol dehydrogenase, prRDH, RalR1, RDH, RDH10, RDH11, Rdh11/12-like 1, Rdh11/12-like 2, Rdh11/12-like 3, RDH12, RDH13, RDH14, RDH8, retinal reductase, retinal reductase 1, retinaldehyde reductase, retinoid dehydrogenase/reductase, retinoid oxidoreductase complex, Retinol dehydrogenase, retinol dehydrogenase 10, retinol dehydrogenase 11, retinol dehydrogenase 12, retinol dehydrogenase 13, retinol dehydrogenase 8, retinol dehydrogenase [NADP+], retinol dehydrogenase-10, retinol dehydrogenases 11-like, retSDR1, RHD8, ROC, SDR16C4, short-chain dehydrogenase/reductase RRD

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.300 NADP-retinol dehydrogenase

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Results	in table
1173	AA Sequence
3	Application
1	CAS Registry Number
30	Cloned(Commentary)
88	Cofactor
1	Crystallization (Commentary)
36	Disease/ Diagnostics
2	Expression
66	General Information
7	Inhibitors
5	kcat/KM [mM/s]
1	Ki Value [mM]
67	KM Value [mM]
30	Localization
8	Molecular Weight [Da]
43	Natural Substrates/ Products (Substrates)
86	Organism
1	Oxidation Stability
2	Pathway
11	PDB ID
3	pH Optimum
2	pI Value
1	Posttranslational Modification
43	Protein Variants
9	Purification (Commentary)
1	Reaction
67	Reference
131	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
112	Substrates and Products (Substrate)
6	Subunits
133	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Stability [°C]
12	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.300 - NADP-retinol dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

retinol:NADP+ oxidoreductase

Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63 (beta-carotene 15,15'-dioxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH.