1.1.1.23: histidinol dehydrogenase
This is an abbreviated version!
For detailed information about histidinol dehydrogenase, go to the full flat file.
Reaction
Synonyms
11412251, BN980_GECA03s06082g, BsHDH, GcHDH, HDH, HIS4 protein, HisD, histidinol dehydrogenase, HLDase, L-histidinol dehydrogenase
ECTree
1.1.1.23 histidinol dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.1.23 - histidinol dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal
-
-
ir
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
-
-
ir
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
ir
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinal + NAD+ + H2O
L-histidine + NADH + H+
-
reaction intermediate
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
part of L-histidine biosynthesis
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
ir
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 2 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
two steps: NAD+-dependent oxidations of L-histidinol to L-histidinaldehyde and subsequently to L-histidine
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
two steps: NAD+-dependent oxidations of L-histidinol to L-histidinaldehyde and subsequently to L-histidine
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
the enzyme is highly specific for histidinol and NAD+
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
via L-histidinaldehyde intermediate
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
NAD+- and Zn+-dependent conversion of L-histidinol to L-histidine through an L-histidinaldehyde intermediate, leading to the concomitant reduction of 2 NAD+ molecules
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
NAD+- and Zn+-dependent conversion of L-histidinol to L-histidine through an L-histidinaldehyde intermediate, leading to the concomitant reduction of 2 NAD+ molecules
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
via L-histidinaldehyde intermediate
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
-
-
-
?
L-histidinol + 2 NAD+ + H2O
L-histidine + 2 NADH + 3 H+
the enzyme is highly specific for histidinol and NAD+
-
-
?
L-histidinol + NAD+
L-histidinal + NADH + H+
-
enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal
-
-
ir
additional information
?
-
active site binding structure for substrates L-histidinol, L-histamine, and L-histidine, NMR study
-
-
?
additional information
?
-
ligand-protein interactions in the active site of GcHDH, molecular docking, overview
-
-
?
additional information
?
-
-
ligand-protein interactions in the active site of GcHDH, molecular docking, overview
-
-
?
additional information
?
-
imidazole-containing substrate analogues are likely to bind to free enzyme
-
-
?
additional information
?
-
imidazole-containing substrate analogues are likely to bind to free enzyme
-
-
?
