1.1.1.23: histidinol dehydrogenase
This is an abbreviated version!
For detailed information about histidinol dehydrogenase, go to the full flat file.
Reaction
Synonyms
11412251, BN980_GECA03s06082g, BsHDH, GcHDH, HDH, HIS4 protein, HisD, histidinol dehydrogenase, HLDase, L-histidinol dehydrogenase
ECTree
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Reaction
Reaction on EC 1.1.1.23 - histidinol dehydrogenase
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bi uni uni bi ping pong mechanism, recombinant histidinol dehydrogenase
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L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
fast reversible oxidation of L-histidanol, followed by slow irreversible hydride transfer from the intermediate L-histidinal
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L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
also oxidizes L-histidinal
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L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
reaction mechanism, amino acid residues Glu326 and His327 are involved in catalysis
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
bi uni uni bi ping-pong enzyme mechanism for MtHisD-catalyzed chemical reaction, involves abstraction of the hydroxyl group proton of L-histidinol by His336 and concomitant hydride transfer from the reactive carbon (carbon bound to the hydroxyl group that upon hydride transfer adopts the sp2 configuration) to NAD+, forming L-histidinaldehyde and transiently protonated His336
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
enzyme HisD from Mycobacterium tuberculosis follows a bi uni uni bi ping-pong mechanism in which L-histidinol is the first substrate to bind and L-histidine the last product to dissociate, the amino acid side chains of His336 and Glu335 are likely involved in catalysis and/or substrate binding
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
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L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
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L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
enzyme HisD from Mycobacterium tuberculosis follows a bi uni uni bi ping-pong mechanism in which L-histidinol is the first substrate to bind and L-histidine the last product to dissociate, the amino acid side chains of His336 and Glu335 are likely involved in catalysis and/or substrate binding
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L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
-
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L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
bi uni uni bi ping-pong enzyme mechanism for MtHisD-catalyzed chemical reaction, involves abstraction of the hydroxyl group proton of L-histidinol by His336 and concomitant hydride transfer from the reactive carbon (carbon bound to the hydroxyl group that upon hydride transfer adopts the sp2 configuration) to NAD+, forming L-histidinaldehyde and transiently protonated His336
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L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism
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