1.1.1.23: histidinol dehydrogenase

0.16

(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-methylphenyl)sulfonyl]propanehydrazide

Brucella suis

pH 9.2, 30°C

0.025

(2S)-2-amino-N'-(biphenyl-4-ylsulfonyl)-3-(1H-imidazol-4-yl)propanehydrazide

0.07

(2S)-2-amino-N'-[(4-bromophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide

Brucella suis

pH 9.2, 30°C

0.0028

(3S)-3-amino-1-(2,3,4,5,6-pentafluorophenyloxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.0192

(3S)-3-amino-1-(2,3,4,5,6-pentafluorophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.01

(3S)-3-amino-1-(2,4-difluorophenyl)-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.19

0.0016

(3S)-3-amino-1-(4-bromophenoxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.006

(3S)-3-amino-1-(4-bromophenyl)-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.16

0.0028

(3S)-3-amino-1-(4-bromophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.012

(3S)-3-amino-1-(4-chlorophenyl)-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.17

0.0047

(3S)-3-amino-1-(4-fluorophenoxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.0031

(3S)-3-amino-1-(4-fluorophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.00004

(3S)-3-amino-1-(4-hydroxyphenyl)-4-(1H-imidazol-4-yl)butan-2-one

Brassica oleracea

P24226

pH and temperature not specified in the publication

0.012

(3S)-3-amino-1-([1,1'-biphenyl]-4-yl)-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.20

0.000024

(3S)-3-amino-1-hydroxy-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.0021

(3S)-3-amino-1-thio-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.000003 - 3

(3S)-3-amino-1-[4-(benzyloxy)phenyl]-4-(1H-imidazol-4-yl)butan-2-one

(3S)-3-amino-1-[4-[(4-butylbenzyl)oxy]phenyl]-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-1-[4-[(4-tert-butylphenyl)ethynyl]phenyl]-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

pH and temperature not specified in the publication

0.015

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-methylphenyl)butan-2-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.18

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]phenyl)butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[[4-(naphthalen-2-yl)benzyl]oxy]phenyl)butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[[4-(trifluoromethyl)benzyl]oxy]phenyl)butan-2-one

Brucella suis

pH and temperature not specified in the publication

0.00011

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-yloxy)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.0033

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-ylthio)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.00021

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(p-tolyloxy)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.0037

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(phenyloxy)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.0071

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(phenylthio)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.0395

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(tolylthio)butan-2-one dihydrochloride

Brucella sp.

pH 9.2, 30°C, recombinant His6-tagged enzyme

0.001

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-phenylbutan-2-one

Escherichia coli

P06988

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(2-phenylethyl)phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

0.009

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(7-phenylhept-1-yn-1-yl)phenyl]butan-2-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.21

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(phenylethynyl)phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(1E)-3-phenylprop-1-en-1-yl]phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methoxybenzyl)oxy]phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methylbenzyl)oxy]phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methylphenyl)ethynyl]phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

8.5

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-pentylphenyl)ethynyl]phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-phenoxybenzyl)oxy]phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(E)-2-(4-methylphenyl)ethenyl]phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(E)-2-phenylethenyl]phenyl]butan-2-one

Brucella suis

pH and temperature not specified in the publication

0.000003 - 0.00007

(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[4-(phenylethynyl)benzyl]phenyl]butan-2-one

0.005

(3S)-3-amino-4-(1H-imidazol-4-yl)butan-2-one

Salmonella enterica subsp. enterica serovar Typhimurium

P10370

pH and temperature not specified in the publication

0.0587

(7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid

Geotrichum candidum

0.143

(7S)-7-[(2,4-difluorophenyl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.6

0.098

(7S)-7-[(4-bromophenyl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.3

0.092

(7S)-7-[(4-chlorophenyl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.4

0.113

(7S)-7-[(4-methylphenyl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.5

0.086

(7S)-7-[([1,1'-biphenyl]-4-yl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.7

0.175

(7S)-7-[[4-(7-phenylhept-1-yn-1-yl)phenyl]acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.8

0.005

(8S)-8-[2-(biphenyl-4-yl)ethanethioyl]-7,8-dihydroimidazo[1,5-c]pyrimidine-5(6H)-thione

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000003

(S)-3-amino-1-(4-(benzyloxy)phenyl)-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

pH 9.2, 30°C

0.000006

(S)-3-amino-1-(4-bromophenyl)-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

pH 9.2, 30°C

0.000012

(S)-3-amino-1-(4-chlorophenyl)-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

pH 9.2, 30°C

0.000015

(S)-3-amino-1-(4-fluorophenyl)-4-(1H-imidazol-4-yl)butan-2-one

Brucella suis

pH 9.2, 30°C

0.000016

(S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-phenoxyphenyl)butan-2-one

Brucella suis

pH 9.2, 30°C

0.0000145

(S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-yl)butan-2-one

Brucella suis

pH 9.2, 30°C

0.000015

(S)-3-amino-4-(1H-imidazol-4-yl)-1-p-tolylbutan-2-one

Brucella suis

pH 9.2, 30°C

0.0587

1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid

Geotrichum candidum

pH not specified in the publication, temperature not specified in the publication

0.095

2-(2,4-difluorophenyl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.13

0.105

2-(4-bromophenyl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.10

0.074

2-(4-chlorophenyl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.11

0.095

2-(4-methylphenyl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.12

0.005

2-([1,1'-biphenyl]-4-yl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.14

0.005

2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(4-methoxyphenyl)methylidene]propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.0055

2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(4-methylphenyl)methylidene]propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.0025

2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(4-nitrophenyl)methylidene]propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.0098

2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(4-phenoxyphenyl)methylidene]propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.0011

2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(naphthalen-2-yl)methylidene]propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.029

2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-phenylmethylidene]propanehydrazide (non-preferred name)

Mycobacterium tuberculosis

pH 7.2, 25°C

0.027

2-amino-N'-[(E)-(2-hydroxyphenyl)methylidene]-3-(1H-imidazol-4-yl)propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.0077

2-amino-N'-[(E)-(4-bromophenyl)methylidene]-3-(1H-imidazol-4-yl)propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.0024

2-amino-N'-[(E)-(4-chlorophenyl)methylidene]-3-(1H-imidazol-4-yl)propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.0024

2-amino-N'-[(E)-(4-fluorophenyl)methylidene]-3-(1H-imidazol-4-yl)propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.0091

2-amino-N'-[(E)-[4-(dimethylamino)phenyl]methylidene]-3-(1H-imidazol-4-yl)propanehydrazide

Mycobacterium tuberculosis

pH 7.2, 25°C

0.322

2-[4-(7-phenylhept-1-yn-1-yl)phenyl]-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.15

0.00317

3-(1H-imidazol-4-yl)propanoic acid

Geotrichum candidum

pH not specified in the publication, temperature not specified in the publication

0.00356

5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid

Geotrichum candidum

pH not specified in the publication, temperature not specified in the publication

0.0242

7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

0.0064

imidazole-4-carboxylic acid

Geotrichum candidum

0.1222

methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate

Geotrichum candidum

0.532

methyl (7S)-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.2

0.018

methyl (7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate

Brucella suis

at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.9

0.1222

methyl 1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate

Geotrichum candidum

pH not specified in the publication, temperature not specified in the publication

0.0293

methyl 1-methyl-N-(phenoxycarbonyl)histidinate

Geotrichum candidum

pH not specified in the publication, temperature not specified in the publication

0.0052

methyl 3-(1H-imidazol-4-yl)propanoate

0.0293

methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate

Geotrichum candidum

0.0106

methyl N-(methoxycarbonyl)-3-methyl-L-histidinate

Geotrichum candidum

0.0106

methyl N-(methoxycarbonyl)histidinate

Geotrichum candidum

pH not specified in the publication, temperature not specified in the publication