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1.1.1.21: aldose reductase

This is an abbreviated version!
For detailed information about aldose reductase, go to the full flat file.

Word Map on EC 1.1.1.21

Reaction

alditol
+
NAD(P)+
=
aldose
+
NAD(P)H
+
H+

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B1, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, EC 1.1.1.139, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH dependent xylose reductase, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.21 aldose reductase

Expression

Expression on EC 1.1.1.21 - aldose reductase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
aldose reductase is upregulated in hyperglycemia
expression of enzyme aldose reductase is upregulated in microglia/macrophages after spinal cord injury in wild-type mice. In enzyme knockout mice, spinal cord injury leads to smaller injury lesion areas compared to wild-type
fidarestat significantly inhibits the enzyme activity as well as the enzyme expression
inhibition of the enzyme activity also inhibits the expression of the enzyme protein in xenograft tissue
-
lippolysaccharide, from Salmonella enterica serotype typhimurium, induces the enzyme in mouse retina
maximum activity is recorded with 3.25% xylose, 0.125% MgSO4 using 24 h old inoculum after 108 h of incubation at 32.5 °C. The enzyme activity shows 3.81folds increase over the control (33.07 U/mg) with up to 64% xylose conversion after optimization
-
upregulation of the aldose reductase pathway with aging
-