EC 1.1.1.209: 3(or 17)alpha-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 3(or 17)alpha-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.209
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1.1.1.209
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17beta-hydroxysteroids
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testosterone
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aldo-keto
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3beta-hsd
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neurosteroids
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steroidogenesis
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epitestosterone
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17-ketosteroids
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leydig
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corticosterone
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17alpha-hydroxysteroids
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3alpha-hydroxysteroid
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3beta-hydroxysteroid
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5alpha-reductase
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lh-stimulated
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17alpha
- 1.1.1.209
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17beta-hydroxysteroids
- testosterone
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aldo-keto
- 3beta-hsd
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neurosteroids
-
steroidogenesis
- epitestosterone
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17-ketosteroids
- leydig
- corticosterone
- 17alpha-hydroxysteroids
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3alpha-hydroxysteroid
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3beta-hydroxysteroid
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5alpha-reductase
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lh-stimulated
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17alpha
Reaction
Synonyms
3(17)alpha-hydroxysteroid dehydrogenase, 3beta- and 17beta-hydroxysteroid dehydrogenase, AKR1C21, dehydrogenase, 3(17)alpha-hydroxy steroid, More
ECTree
1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.1.209 - 3(or 17)alpha-hydroxysteroid dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY 
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide + NADPH + H+
3alpha-androstanediol + NADP+
-
Substrates: i.e., 5alpha-dihydrotestosterone
Products: -
Products: -
?
(R)-1-indanol + NADP+
1-indanone + NADPH
-
Substrates: 37% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
(S)-1-indanole + NADP+
1-indanone + NADPH
-
Substrates: 7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
1-acenaphthenol + NADP+
1-acenaphthenone + NADPH
-
Substrates: 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
21-hydroxy-5beta-pregnane-3,20-dione + NADPH
21-hydroxy-5beta-pregnane-20alpha-ol-3-one + NADP+
Substrates: -
Products: -
Products: -
r
3alpha-androstanediol + NAD(P)+
androsterone + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
4-androstene-3,17-dione + NADPH + H+
? + NADP+
Substrates: -
Products: -
Products: -
r
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
-
Substrates: 58% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5-androstene-3beta,17beta-diol + NADP+
? + NADPH
Substrates: no substrate for wild-type, but substrate for mutants Y224F, Y224D, Q222D
Products: -
Products: -
?
5alpha-androstan-17alpha-ol-3-one + NADP+
5alpha-androstan-3,17-dione + NADPH + H+
Substrates: -
Products: -
Products: -
?
5alpha-androstan-17alpha-ol-3-one + NADP+
? + NADPH
Substrates: -
Products: -
Products: -
?
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H
5alpha-androstan-3alpha-ol-17-one + NADPH
? + NADP+
Substrates: -
Products: -
Products: -
?
5alpha-androstan-3alpha-ol-17-one + NADPH + H+
5alpha-androstan-3alpha-ol-17beta-ol + NADP+
Substrates: -
Products: -
Products: -
?
5alpha-androstan-3beta,17beta-diol + NADP+
? + NADPH
Substrates: -
Products: -
Products: -
?
5alpha-androstan-3beta,17beta-diol + NADP+
? + NADPH + H+
Substrates: -
Products: -
Products: -
?
5alpha-androstane-3alpha,17beta-diol + NADP+
5alpha-androstane-17beta-ol-3-one + NADPH
-
Substrates: 7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5alpha-dihydrotestosterone + NAD(P)H
androstanedione + NAD(P)+
-
Substrates: -
Products: -
Products: -
r
5alpha-pregnan-3alpha,20alpha-diol + NADP+
5alpha-pregnan-20alpha-ol-3-one + NADPH
-
Substrates: 6% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5alpha-pregnan-3alpha,21-diol-20-one + NADP+
5alpha-pregnan-21alpha-ol-3,20-dione + NADPH
-
Substrates: 7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5alpha-pregnane-21-ol-3,20-dione + NADPH
5beta-pregnane-3alpha,21-diol-20-one + NADP+
-
Substrates: 75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5alpha-pregnane-3,20-dione + NADPH
5alpha-pregnane-3alpha-ol-20-one + NADP+
-
Substrates: 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5alpha-pregnane-3alpha,20alpha-diol + NADP+
? + NADPH
Substrates: -
Products: -
Products: -
?
5beta-androstan-17alpha-ol-3-one + NADP+
? + NADPH
Substrates: -
Products: -
Products: -
?
5beta-androstan-17beta-ol-3-one + NADPH
5beta-androstan-17beta,3alpha-diol + NADP+
-
Substrates: 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5beta-androstane-3,17-dione + NADPH
5beta-androstan-3alpha-ol-17-one + NADP+
-
Substrates: 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5beta-androstane-3alpha,17beta-diol + NADP+
5beta-androstane-17beta-ol-3-one + NADPH
-
Substrates: 11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5beta-androstane-3alpha-ol-17-one + NADP+
5beta-androstane-3,17-dione + NADPH
-
Substrates: 9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5beta-pregnan-3alpha,20alpha-diol + NADP+
5beta-pregnan-3-one-20alpha-ol + NADPH
-
Substrates: 26% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5beta-pregnan-3alpha-ol-20-one + NADP+
5beta-pregnan-3,20-dione + NADPH
-
Substrates: 19% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5beta-pregnane-20alpha-ol-3-one + NADP+
5beta-pregnane-3alpha,20alpha-diol + NADPH + H+
Substrates: -
Products: -
Products: -
r
5beta-pregnane-3alpha,20alpha-diol + NADP+
? + NADPH
Substrates: -
Products: -
Products: -
?
acenaphthenequinone + NADPH
acenaphthenehydroquinone + NADP+
-
Substrates: 44% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
androst-4-ene-3,17-dione + NADPH
androst-4-ene-3alpha-ol-17-one + NADP+
-
Substrates: 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
androstenedione + NADPH + H+
androsterone + NADP+
Substrates: -
Products: -
Products: -
r
camphorquinone + NADPH + H+
camphorhydroquinone + NADP+
-
Substrates: 52% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
cis-1,2-dihydroxy-3,5-cyclohexadiene + NADP+
catechol + NADPH
-
Substrates: 60% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
cyclohex-2-ene-1-ol + NADP+
cyclohex-2-en-1-one + NADPH
-
Substrates: 9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
cyclohexanone + NADPH
cyclohexanol + NADP+
-
Substrates: 16% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
estrone 3-sulfate + NAD(P)H
17alpha-estradiol 3-sulfate + NAD(P)+
-
Substrates: -
Products: -
Products: -
?
glycolithocholic acid + NADP+
N-[(5beta)-3,24-dioxocholan-24-yl]glycine + NADPH
-
Substrates: 56% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
naphthalene dihydrodiol + NADP+
naphthacatechol + NADPH
-
Substrates: 49% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
pyridine-4-ol + NADP+
3H-pyridine-4-one + NADPH
-
Substrates: 75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
testosterone + NAD(P)+
androstenedione + NAD(P)H + H+
-
Substrates: -
Products: -
Products: -
?
testosterone + NADP+
androst-4-en-3,17-dione + NADPH + H+
Substrates: mutant G225P/G226P, wild-type shows no activity with testosterone
Products: -
Products: -
?
trans-1,2-dihydroxy-3,5-cyclohexadiene + NADP+
catechol + NADPH
-
Substrates: -
Products: -
Products: -
?
17alpha-estradiol + NAD(P)+
estrone + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
17alpha-estradiol + NAD(P)+
estrone + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
17alpha-estradiol 3-glucuronide + NAD(P)+
estrone 3-glucuronide + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
17alpha-estradiol 3-glucuronide + NAD(P)+
estrone 3-glucuronide + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
3alpha-hydroxy-5alpha-androstan-17-one + NAD(P)+
5alpha-androstan-3,17-dione + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
3alpha-hydroxy-5alpha-androstan-17-one + NAD(P)+
5alpha-androstan-3,17-dione + NAD(P)H
-
Substrates: i.e. androsterone
Products: -
Products: -
?
5alpha-androstan-17beta-ol-3-one + NADP+
5alpha-androstan-3,17-dione + NADPH + H+
Substrates: wild-type shows no activity with 5alpha-androstan-17beta-ol-3-one
Products: -
Products: -
?
5alpha-androstan-17beta-ol-3-one + NADP+
5alpha-androstan-3,17-dione + NADPH + H+
Substrates: -
Products: no substrate for wild-type, but substrate for mutants Y224F, Y224D, Q222D
Products: no substrate for wild-type, but substrate for mutants Y224F, Y224D, Q222D
?
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H
-
Substrates: -
Products: i.e. 5alpha-dihydrotestosterone
Products: i.e. 5alpha-dihydrotestosterone
r
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
5beta-pregnane-3,20-dione + NADPH + H+
5beta-pregnane-3alpha-ol-20-one + NADP+
-
Substrates: 21% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
5beta-pregnane-3,20-dione + NADPH + H+
5beta-pregnane-3alpha-ol-20-one + NADP+
Substrates: -
Products: -
Products: -
r
5beta-pregnane-3alpha,20alpha-diol + NADPH + H+
5beta-pregnane-20alpha-ol-3-one + NADP+
Substrates: -
Products: -
Products: -
r
5beta-pregnane-3alpha,20alpha-diol + NADPH + H+
5beta-pregnane-20alpha-ol-3-one + NADP+
-
Substrates: -
Products: -
Products: -
r
epitestosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
Substrates: -
Products: -
Products: -
r
epitestosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
Substrates: -
Products: -
Products: -
?
epitestosterone + NADP+
testosterone + NADPH + H+
-
Substrates: 11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene
Products: -
Products: -
?
epitestosterone + NADP+
testosterone + NADPH + H+
Substrates: -
Products: -
Products: -
?
additional information
?
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Substrates: the enzyme catalyses the oxidoreduction of steroid hormones such as estrogens, androgens and neurosteroids
Products: -
Products: -
?
additional information
?
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Substrates: a bifunctional enzyme that catalyses the oxidoreduction of the 3- and 17-hydroxy/keto groups of steroid substrates such as oestrogens, androgens and neurosteroids, 5beta-pregnane-3alpha,20alpha-diol, 21-hydroxy-5beta-pregnane-3,20-dione, and androstenedione are docked into the substrate-binding cavity and structure analysis, Lys31, Gly225 and Gly226 are important for ligand recognition and orientation in the active site, molecular-docking simulations, overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: a bifunctional enzyme that catalyses the oxidoreduction of the 3- and 17-hydroxy/keto groups of steroid substrates such as oestrogens, androgens and neurosteroids, 5beta-pregnane-3alpha,20alpha-diol, 21-hydroxy-5beta-pregnane-3,20-dione, and androstenedione are docked into the substrate-binding cavity and structure analysis, Lys31, Gly225 and Gly226 are important for ligand recognition and orientation in the active site, molecular-docking simulations, overview
Products: -
Products: -
?
additional information
?
-
Substrates: wild-type shows no activity with testosterone and 5alpha-androstan-17beta-ol-3-one
Products: -
Products: -
?
additional information
?
-
-
Substrates: wild-type shows no activity with testosterone and 5alpha-androstan-17beta-ol-3-one
Products: -
Products: -
?
