1.1.1.170: 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
This is an abbreviated version!
For detailed information about 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), go to the full flat file.
Reaction
Synonyms
3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating), 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, 4alpha-carboxylic acid decarboxylase, C-3 sterol dehydrogenase(C-4 decarboxylase), Erg26, Erg26p, NSDHL, sterol 4alpha-carboxylic decarboxylase, sterol-4-alpha-carboxylate 3-dehydrogenase, sterol-4-alpha-carboxylate-3-dehydrogenase, sterol-4alpha-carboxylate 3-dehydrogenase
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Natural Substrates Products on EC 1.1.1.170 - 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
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REACTION DIAGRAM
3beta-hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-carboxylate + NAD+
4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
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3beta-hydroxy-4beta-methyl-5alpha-cholest-7-en-4alpha-oic acid + NAD+
4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
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no epimerization of 4beta-isomer into 4alpha-isomer
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ir
additional information
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involved in the removal of C-4 methyl groups in postsqualene cholesterol synthesis
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a 3-oxosteroid + CO2 + NAD(P)H
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a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
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?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
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?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
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?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
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?