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1.1.1.17: mannitol-1-phosphate 5-dehydrogenase

This is an abbreviated version!
For detailed information about mannitol-1-phosphate 5-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.17

Reaction

D-mannitol 1-phosphate
+
NAD+
=
D-fructose 6-phosphate
+
NADH
+
H+

Synonyms

BbMPD, BMMGA3_01075, BMMGA3_RS01080, D-mannitol-1-phosphate dehydrogenase, dehydrogenase, mannitol 1-phosphate, EsM1PDH1, EsM1PDH2, EsM1PDH3, fructose 6-phosphate reductase, HAD hydrolase, family IA, variant 3, hexose reductase, HMPREF0010_00722, long-chain mannitol-1-phosphate 5-dehydrogenase, long-chain mannitol-1-phosphate dehydrogenase, M1PDH, M1PDH1, M1PDH2, M1PDH3, mannitol 1-phosphate 5-dehydrogenase, mannitol 1-phosphate dehydrogenase, mannitol-1-phosphate dehydrogenase, More, MPD, MpdA, MPDH, MPDH1, MPDH2, MPDH3, Mtl-1-P dehydrogenase, MtlD, NAD+-dependent mannitol-1-phosphate dehydrogenase, NADH-dependent mannitol-1-phosphate 5-dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.17 mannitol-1-phosphate 5-dehydrogenase

Reference

Reference on EC 1.1.1.17 - mannitol-1-phosphate 5-dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schmatz D.M.; Baginsky W.F.; Turner, M.J.
Evidence for and characterization of a mannitol cycle in Eimeria tenella
Mol. Biochem. Parasitol.
32
263-270
1989
Eimeria tenella (O96437), Eimeria tenella
Manually annotated by BRENDA team
Liss, M.; Horwitz, S.B.; Kaplan, N.O.
D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes
J. Biol. Chem.
237
1342-1350
1962
Klebsiella aerogenes
Manually annotated by BRENDA team
Novotny, M.J.; Reizer, J.; Esch, F.; Saier, M.H.
Purification and properties of D-mannitol-1-phosphate dehydrogenase and D-glucitol-6-phosphate dehydrogenase from Escherichia coli
J. Bacteriol.
159
986-990
1984
Escherichia coli
Manually annotated by BRENDA team
Mehta, R.J.; Fare, L.R.; Shearer, M.E.; Nash, C.H.
Mannitol oxidation in two Micromonospora isolates and in representative species of other actinomycetes
Appl. Environ. Microbiol.
33
1013-1015
1977
Amycolatopsis lactamdurans, Micromonospora sp., no activity in Actinoplanes missouriensis, no activity in Mycobacterium smegmatis, no activity in Nocardia erythropolis
Manually annotated by BRENDA team
Otte, S.; Lengeler, J.W.
The mtl genes and the mannitol-1-phosphate dehydrogenase from Klebsiella pneumoniae KAY2026
FEMS Microbiol. Lett.
194
221-227
2001
Klebsiella pneumoniae
Manually annotated by BRENDA team
Survarna, K.; Bartiss, A.; Wong, B.
Mannitol-1-phosphate dehydrogenase from Cryptococcus neoformans is a zinc-containing long-chain alcohol/polyol dehydrogenase
Microbiology
146
2705-2713
2000
Cryptococcus neoformans
Manually annotated by BRENDA team
Henstra, S.A.; Tolner, B.; Ten Hoeve Duurkens, R.H.; Konings, W.N.; Robillard, G.T.
Cloning, expression, and isolation of the mannitol transport protein from the thermophilic bacterium Bacillus stearothermophilus
J. Bacteriol.
178
5586-5591
1996
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Singh, S.P.; Rogers, P.J.
Isolation and characterization of mannitol-1-phosphate dehydrogenase from Brochothrix thermosphacta
J. Gen. Appl. Microbiol.
39
327-337
1993
Brochothrix thermosphacta
-
Manually annotated by BRENDA team
Honeyman, A.L.; Curtiss III, R.
Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system
Infect. Immun.
60
3369-3375
1992
Streptococcus mutans
Manually annotated by BRENDA team
Fischer, R.; von Strandmann, R.P.; Hengstenberg, W.
Mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Enterococcus faecalis: Molecular cloning and nucleotide sequences of the enzyme III Mtl gene and the mannitol-1-phosphate dehydrogenase gene, expression in Escherichia coli, and comparison of the gene products with similar enzymes
J. Bacteriol.
173
3709-3715
1991
Enterococcus faecalis, Staphylococcus carnosus
Manually annotated by BRENDA team
Chase, T.
Mannitol-1-phosphate dehydrogenase of Escherichia coli
Biochem. J.
239
435-443
1986
Escherichia coli
Manually annotated by BRENDA team
Foreman, J.E.; Niehaus, W.G.
Zn2+-induced cooperativity of mannitol-1-phosphate dehydrogenase from Aspergillus parasiticus
J. Biol. Chem.
260
10019-10022
1985
Aspergillus niger, Aspergillus parasiticus
Manually annotated by BRENDA team
Kiser, R.C.; Niehaus, W.G.
Purification and kinetic characterization of mannitol-1-phosphate dehydrogenase from Aspergillus niger
Arch. Biochem. Biophys.
211
613-621
1981
Aspergillus niger
Manually annotated by BRENDA team
Brown, A.T.; Bowles, R.D.
Polyol metabolism by a caries-conductive Streptococcus: Purification and properties of a nicotinamide adenine dinucleotide-dependent mannitol-1-phosphate dehydrogenase
Infect. Immun.
16
163-173
1977
Streptococcus mutans
Manually annotated by BRENDA team
Hankinson, O.; Cove, D.J.
Regulation of mannitol-1-phosphate dehydrogenase in Aspergillus nidulans
Can. J. Microbiol.
21
99-101
1975
Aspergillus nidulans
Manually annotated by BRENDA team
Wolff, J.B.; Kaplan, N.O.
D-Mannitol-1-phosphate dehydrogenase from E. coli
Methods Enzymol.
1
346-348
1955
Escherichia coli
-
Manually annotated by BRENDA team
Wisselink, H.W.; Mars, A.E.; van der Meer, P.; Eggink, G.; Hugenholtz, J.
Metabolic engineering of mannitol production in Lactococcus lactis: influence of overexpression of mannitol 1-phosphate dehydrogenase in different genetic backgrounds
Appl. Environ. Microbiol.
70
4286-4292
2004
Lactococcus plantarum
Manually annotated by BRENDA team
Watanabe, S.; Hamano, M.; Kakeshita, H.; Bunai, K.; Tojo, S.; Yamaguchi, H.; Fujita, Y.; Wong, S.L.; Yamane, K.
Mannitol-1-phosphate dehydrogenase (MtlD) is required for mannitol and glucitol assimilation in Bacillus subtilis: possible cooperation of mtl and gut operons
J. Bacteriol.
185
4816-4824
2003
Bacillus subtilis
Manually annotated by BRENDA team
Iwamoto, K.; Kawanobe, H.; Ikawa, T.; Shiraiwa, Y.
Characterization of salt-regulated mannitol-1-phosphate dehydrogenase in the red alga Caloglossa continua
Plant Physiol.
133
893-900
2003
Caloglossa continua
Manually annotated by BRENDA team
Chiang, Y.; Stushnoff, C.; McSay, A.E.; Jones, M.L.; Bohnert, H.J.
Overexpression of mannitol-1-phosphate dehydrogenase increases mannitol accumulation and adds protection against chilling injury in Petunia
J. Am. Soc. Hort. Sci.
130
605-610
2005
Escherichia coli
-
Manually annotated by BRENDA team
Solomon, P.S.; Tan, K.C.; Oliver, R.P.
Mannitol 1-phosphate metabolism is required for sporulation in planta of the wheat pathogen Stagonospora nodorum
Mol. Plant Microbe Interact.
18
110-115
2005
Parastagonospora nodorum (Q0U6E8), Parastagonospora nodorum
Manually annotated by BRENDA team
Tang, W.; Peng, X.; Newton, R.J.
Enhanced tolerance to salt stress in transgenic loblolly pine simultaneously expressing two genes encoding mannitol-1-phosphate dehydrogenase and glucitol-6-phosphate dehydrogenase
Plant Physiol. Biochem.
43
139-146
2005
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Ladero, V.; Ramos, A.; Wiersma, A.; Goffin, P.; Schanck, A.; Kleerebezem, M.; Hugenholtz, J.; Smid, E.J.; Hols, P.
High-level production of the low-calorie sugar sorbitol by Lactobacillus plantarum through metabolic engineering
Appl. Environ. Microbiol.
73
1864-1872
2007
Lactiplantibacillus plantarum
Manually annotated by BRENDA team
Krahulec, S.; Armao, G.C.; Weber, H.; Klimacek, M.; Nidetzky, B.
Characterization of recombinant Aspergillus fumigatus mannitol-1-phosphate 5-dehydrogenase and its application for the stereoselective synthesis of protio and deuterio forms of D-mannitol 1-phosphate
Carbohydr. Res.
343
1414-1423
2008
Aspergillus fumigatus (Q4X1A4), Aspergillus fumigatus
Manually annotated by BRENDA team
Velez, H.; Glassbrook, N.J.; Daub, M.E.
Mannitol biosynthesis is required for plant pathogenicity by Alternaria alternata
FEMS Microbiol. Lett.
285
122-129
2008
Alternaria alternata, Alternaria alternata A5
Manually annotated by BRENDA team
Pujni, D.; Chaudhary, A.; Rajam, M.V.
Increased tolerance to salinity and drought in transgenic indica rice by mannitol accumulation
J. Plant Biochem. Biotechnol.
16
1-7
2007
Escherichia coli
-
Manually annotated by BRENDA team
Krahulec, S.; Armao, G.C.; Bubner, P.; Klimacek, M.; Nidetzky, B.
Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies of mannitol 2-dehydrogenase and mannitol-1-phosphate 5-dehydrogenase
Chem. Biol. Interact.
178
274-282
2009
Aspergillus fumigatus
Manually annotated by BRENDA team
Wang, Z.L.; Ying, S.H.; Feng, M.G.
Gene cloning and catalysis features of a new mannitol-1-phosphate dehydrogenase (BbMPD) from Beauveria bassiana
Carbohydr. Res.
345
50-54
2010
Beauveria bassiana (C7FDI4), Beauveria bassiana
Manually annotated by BRENDA team
Aguilar-Osorio, G.; Vankuyk, P.A.; Seiboth, B.; Blom, D.; Solomon, P.S.; Vinck, A.; Kindt, F.; Woesten, H.A.; de Vries, R.P.
Spatial and developmental differentiation of mannitol dehydrogenase and mannitol-1-phosphate dehydrogenase in Aspergillus niger
Eukaryot. Cell
9
1398-1402
2010
Aspergillus niger
Manually annotated by BRENDA team
Sand, M.; Mingote, A.I.; Santos, H.; Mueller, V.; Averhoff, B.
Mannitol, a compatible solute synthesized by Acinetobacter baylyi in a two-step pathway including a salt-induced and salt-dependent mannitol-1-phosphate dehydrogenase
Environ. Microbiol.
15
2187-2197
2013
Acinetobacter baylyi
Manually annotated by BRENDA team
Krahulec, S.; Armao, G.C.; Klimacek, M.; Nidetzky, B.
Enzymes of mannitol metabolism in the human pathogenic fungus Aspergillus fumigatus--kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications
FEBS J.
278
1264-1276
2011
Aspergillus fumigatus
Manually annotated by BRENDA team
Rambhatla, P.; Kumar, S.; Floyd, J.T.; Varela, M.F.
Molecular cloning and characterization of mannitol-1-phosphate dehydrogenase from Vibrio cholerae
J. Microbiol. Biotechnol.
21
914-920
2011
Vibrio cholerae serotype O1
Manually annotated by BRENDA team
Rousvoal, S.; Groisillier, A.; Dittami, S.; Michel, G.; Boyen, C.; Tonon, T.
Mannitol-1-phosphate dehydrogenase activity in Ectocarpus siliculosus, a key role for mannitol synthesis in brown algae
Planta
233
261-273
2011
Ectocarpus siliculosus (D7FMJ8), Ectocarpus siliculosus (D7G793), Ectocarpus siliculosus (D8LI09), Ectocarpus siliculosus, Ectocarpus siliculosus Ec32 / CCAP 1310/4 (D7FMJ8), Ectocarpus siliculosus Ec32 / CCAP 1310/4 (D7G793), Ectocarpus siliculosus Ec32 / CCAP 1310/4 (D8LI09)
Manually annotated by BRENDA team
Sand, M.; Rodrigues, M.; Gonzalez, J.M.; de Crecy-Lagard, V.; Santos, H.; Mueller, V.; Averhoff, B.
Mannitol-1-phosphate dehydrogenases/phosphatases: a family of novel bifunctional enzymes for bacterial adaptation to osmotic stress
Environ. Microbiol.
17
711-719
2015
Acinetobacter baylyi (Q6FBP5), Acinetobacter baylyi ATCC 33305 (Q6FBP5)
Manually annotated by BRENDA team
Bonin, P.; Groisillier, A.; Raimbault, A.; Guibert, A.; Boyen, C.; Tonon, T.
Molecular and biochemical characterization of mannitol-1-phosphate dehydrogenase from the model brown alga Ectocarpus sp.
Phytochemistry
117
509-520
2015
Ectocarpus siliculosus (D7FMJ8), Ectocarpus siliculosus (D7G793), Ectocarpus siliculosus (D8LI09)
Manually annotated by BRENDA team
Bhauso, T.D.; Radhakrishnan, T.; Kumar, A.; Mishra, G.P.; Dobaria, J.R.; Patel, K.; Rajam, M.V.
Overexpression of bacterial mtlD gene in peanut improves drought tolerance through accumulation of mannitol
ScientificWorldJournal
2014
125967
2014
Escherichia coli (P09424)
Manually annotated by BRENDA team
Goudarzi, A.; Jafari, M.; Safaie, N.; Mohammad Jafari, S.
Transgenic sugar beet expressing a bacterial mannitol-1-phosphate dehydrogenase (mtlD) gene shows enhanced resistance to fungal pathogens
Sugar Tech.
18
192-203
2016
Escherichia coli (P09424)
-
Manually annotated by BRENDA team
Zeidler, S.; Hubloher, J.; Koenig, P.; Ngu, N.; Scholz, A.; Averhoff, B.; Mueller, V.
Salt induction and activation of MtlD, the key enzyme in the synthesis of the compatible solute mannitol in Acinetobacter baumannii
MicrobiologyOpen
7
e00614
2018
Acinetobacter baumannii (D0C7J2), Acinetobacter baumannii ATCC 19606 (D0C7J2)
Manually annotated by BRENDA team
Schultenkaemper, K.; Brito, L.F.; Lopez, M.G.; Brautaset, T.; Wendisch, V.F.
Establishment and application of CRISPR interference to affect sporulation, hydrogen peroxide detoxification, and mannitol catabolism in the methylotrophic thermophile Bacillus methanolicus
Appl. Microbiol. Biotechnol.
103
5879-5889
2019
Bacillus methanolicus (I3E3X0), Bacillus methanolicus, Bacillus methanolicus MGA3 (I3E3X0)
Manually annotated by BRENDA team
Lim, J.Y.; Jang, S.H.; Park, H.M.
Mannitol-1-phosphate dehydrogenase, MpdA, is required for mannitol production in vegetative cells and involved in hyphal branching, heat resistance of conidia and sexual development in Aspergillus nidulans
Curr. Genet.
67
613-630
2021
Aspergillus nidulans (Q5B0F5), Aspergillus nidulans, Aspergillus nidulans ATCC 38163 (Q5B0F5)
Manually annotated by BRENDA team
Lopez, M.G.; Irla, M.; Brito, L.F.; Wendisch, V.F.
Characterization of D-arabitol as newly discovered carbon source of Bacillus methanolicus
Front. Microbiol.
10
1725
2019
Corynebacterium glutamicum (A0A0U4Y4V3), Bacillus methanolicus (I3E3X0), Bacillus methanolicus ATCC 53907 (I3E3X0), Bacillus methanolicus MGA3 (I3E3X0)
Manually annotated by BRENDA team
Nguyen, T.; Kim, T.; Ta, H.; Yeo, W.; Choi, J.; Mizar, P.; Lee, S.; Bae, T.; Chaurasia, A.; Kim, K.
Targeting mannitol metabolism as an alternative antimicrobial strategy based on the structure-function study of mannitol-1-phosphate dehydrogenase in Staphylococcus aureus
mBio
10
e02660
2019
Staphylococcus aureus (A8YYC5), Staphylococcus aureus, Staphylococcus aureus USA300 (A8YYC5)
Manually annotated by BRENDA team