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1,10-phenanthroline
-
weak inhibition
2,2'-bipyridyl
-
weak inhibition
4,7-phenanthroline
-
weak inhibition
4-hydroxymercuribenzoate
strong inhibition; strong inhibition; strong inhibition
5,5'-dithiobis-(2-nitrobenzoate)
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complete inactivation at 0.24 mM
adenosine
-
48% inhibition of fructose 6-phosphate reduction
adenosine diphosphoribose
-
competitive inhibition with respect to NADH, noncompetitive inhibition with respect to D-fructose 6-phosphate
Ca2+
35.9% inhibition at 10 mM of the reverse reaction
cytidine
-
17% inhibition of fructose 6-phosphate reduction
D-fructose 1,6-diphosphate
-
12% inhibition of mannitol 1-phosphate oxidation
D-glucose 6-phosphate
-
competitive inhibition with respect to D-fructose 6-phosphate, noncompetitive inhibition with respect to NADH
D-mannitol 1-phosphate
-
competitive inhibition with respect to D-fructose 6-phosphate, noncompetitive inhibition with respect to NADH
diethyldicarbonate
-
60% inhibition at 1 mM
diethyldithiocarbamate
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95% inactivation, prevented by presence of 2-mercaptoethanol
dihydrocelastrol
competitive inhibitor, presence of dihydrocelastrol effectively reduces bacterial cell viability during host infection
DTT
46.0% inhibition at 10 mM of the reverse reaction
fructose-6-phosphate
-
substrate inhibition above 0.5 mM
GTP
-
11% inhibition of mannitol 1-phosphate oxidation
guanosine
-
10% inhibition of fructose 6-phosphate reduction
KCl
at 1.5 M, 52% of maximum activity obtained with NaCl
Li+
24.4% inhibition at 50 mM of the reverse reaction
Mg2+
31.2% inhibition at 10 mM of the reverse reaction
Mn2+
31.3% inhibition at 50 mM of the reverse reaction
N-ethylmaleimide
-
1 mM, 80% inhibition of reduction and oxidation reaction
NaCl
activity is strictly salt dependent, with highest stimulation at 600 mM NaCl and 24% of maximum activity at 1.5 M
NAD+
-
competitive inhibition with respect to NADH, noncompetitive inhibition with respect to D-fructose 6-phosphate
p-hydroxymercuribenzoate
-
0.5 mM, complete inhibition of reduction and oxidation reaction, 2-mercaptoethanol protects
phosphoenolpyruvate
-
14% inhibition of mannitol 1-phosphate oxidation
SDS
80.1% inhibition at 1 mM of the reverse reaction
thymidine
-
8% inhibition of fructose 6-phosphate reduction
uridine
-
16% inhibition of fructose 6-phosphate reduction
ADP
-
competitive inhibition
ADP
-
20% inhibition of mannitol 1-phosphate oxidation
ATP
-
competitive inhibition
ATP
-
53% inhibition of mannitol 1-phosphate oxidation
Cd2+
-
competitive inhibition
Cd2+
-
cooperative binding
Co2+
-
competitive inhibition
Co2+
-
cooperative binding
Cu2+
-
irreversible inactivation
Cu2+
-
irreversible inactivation
Cu2+
32.8% inhibition at 2 mM of the reverse reaction
D-fructose 6-phosphate
-
competitive inhibition with respect to D-mannitol 1-phosphate
D-fructose 6-phosphate
-
56% inhibition of mannitol 1-phosphate oxidation
Hg2+
-
irreversible inactivation
Hg2+
-
irreversible inactivation
NADH
-
-
NADH
-
competitive inhibition with respect to NAD+
Ni2+
-
competitive inhibition
Ni2+
-
cooperative binding
Zn2+
-
competitive with respect to D-fructose 6-phosphate, noncompetitive inhibition with respect to NADH
Zn2+
-
cooperative binding of Zn2+, competitive type if KCl concentration is greater 100 mM, sigmoidal type at lower salt concentrations
Zn2+
44.7% inhibition at 2 mM of the reverse reaction
additional information
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poor effects by ATP, ADP and AMP
-
additional information
no or poor inhibition of the reverse reaction by EDTA and 2-mercaptoethanol
-
additional information
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no or poor inhibition of the reverse reaction by EDTA and 2-mercaptoethanol
-
additional information
no inhibition by EDTA; no inhibition by EDTA; no inhibition by EDTA
-
additional information
no inhibition by EDTA; no inhibition by EDTA; no inhibition by EDTA
-
additional information
no inhibition by EDTA; no inhibition by EDTA; no inhibition by EDTA
-