1.1.1.159: 7alpha-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 7alpha-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.159
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1.1.1.159
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chenodeoxycholic
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cholic
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testosteroni
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bacteroides
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thin-layer
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3alpha-hydroxysteroid
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synthesis
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fragilis
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7alpha-oh
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glycochenodeoxycholic
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nadp-dependent
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ursodeoxycholic
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perfringens
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degradation
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analysis
- 1.1.1.159
-
chenodeoxycholic
-
cholic
- testosteroni
- bacteroides
-
thin-layer
-
3alpha-hydroxysteroid
- synthesis
- fragilis
-
7alpha-oh
-
glycochenodeoxycholic
-
nadp-dependent
-
ursodeoxycholic
- perfringens
- degradation
- analysis
Reaction
Synonyms
7-alpha-HSDH, 7-HSDH, 7alpha-HSD, 7alpha-HSDH, 7alpha-hydroxy steroid dehydrogenase, 7alpha-hydroxysteroid dehydrogenase, Bile acid-inducible protein, CA 7alpha-HSDH, Ca7alpha-HSDH, dehydrogenase, 7alpha-hydroxy steroid, J-1-1, NADP(H)-dependent 7alpha-HSDH, NADP(H)-dependent 7alpha-hydroxysteroid dehydrogenase, NADP+-dependent 7alpha-HSDH, nicotinamide adenine dinucleotide phosphate-dependent 7alpha-hydroxysteroid dehydrogenase
ECTree
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Crystallization
Crystallization on EC 1.1.1.159 - 7alpha-hydroxysteroid dehydrogenase
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purified recombinant enzyme complexed with taurochenodeoxycholic acid and NADP+, sitting drop vapour diffusion method, mixing of 200 nl of 1.12 mM protein in 50 mM Tris-HCl, pH 8.0, 200 mM NaCl,and 5.6 mM of NADP+ and taurochenodeoxycholic acid, with 200 nl of reservoir solution containing 0.1 M HEPES, pH 7.5, and 25% PEG-3350, and equilibration against 0.03 ml reservoir solution, at 20°C, X-ray diffraction structure determination and analysis at 2.0 A resolution
binary complex with NAD+, ternary complex with NADH and 7-oxoglycochenodeoxycholic acid as product, as well as possibly partially glycochenodeoxycholic acid as substrat