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1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version!
For detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Word Map on EC 1.1.1.153

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
 +
NADPH
 +
H+

Synonyms

AKR1B1, MDSPI16 protein, MDSPR, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

Expression

Expression on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
infection with Escherichia coli induces the enzyme in Musca domestica larvae, highest after 24 h
RNAi-mediated SPR expression knockdown in the MYCN2 NB cell line
the enzyme expression is upregulated in hepatocellular carcinoma. The enzyme expression is increased at 1 month 18fold when stabilized and is 17 and 18fold upregulated at 4 and 6 months after carcinogen treatment, respectively
the enzyme mRNA level increases in the brains of Parkinson's disease patients