EC 1.1.1.150: 21-hydroxysteroid dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about 21-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.
Reaction
ECTree
1.1.1.150 21-hydroxysteroid dehydrogenase (NAD+)Advanced search results
results (
results (| Results | in table |
|---|---|
| 1 | CAS Registry Number |
| 2 | Cloned(Commentary) |
| 3 | Cofactor |
| 5 | Inhibitors |
| 8 | KM Value [mM] |
| 3 | Localization |
| 7 | Organism |
| 2 | pH Optimum |
| 1 | Purification (Commentary) |
| 1 | Reaction |
| 3 | Reaction Type |
| 7 | Reference |
| 4 | Source Tissue |
| 12 | Substrates and Products (Substrate) |
| 1 | Systematic Name |
| 1 | Temperature Stability [°C] |
Substrates Products
Substrates Products on EC 1.1.1.150 - 21-hydroxysteroid dehydrogenase (NAD+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY 
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4,11-diene-3,20-dione + NAD+
Ovis aries aries
-
Substrates: i.e. 21-dehydro-delta1-cortisol, only NAD dehydrogenase II
Products: i.e. 21-hydroxy-delta1-cortisol
Products: i.e. 21-hydroxy-delta1-cortisol
?
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
11beta-hydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,21-dihydroxy-pregn-4-ene-3,20-dione + NAD+
Ovis aries aries
-
Substrates: i.e. 21-dehydrocorticosterone, only NAD dehydrogenase II
Products: i.e. 21-hydroxycorticosterone
Products: i.e. 21-hydroxycorticosterone
?
17-hydroxy-pregn-4-ene-3,11,20,21-tetraone + NADH
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NAD+
Ovis aries aries
-
Substrates: i.e. 21-dehydrocortisone
Products: i.e. cortisone
Products: i.e. cortisone
?
17-hydroxy-pregn-4-ene-3,20,21-trione + NADH
17,21-dihydroxy-pregn-4-ene-3,20-dione + NAD+
Ovis aries aries
-
Substrates: i.e. 21-dehydro-11-deoxycortisol, only NAD dehydrogenase II
Products: i.e. 21-hydroxy-11-deoxycortisol
Products: i.e. 21-hydroxy-11-deoxycortisol
?
5beta-pregnane-3alpha,21-diol-20-one + NAD+
5beta-pregnane-3alpha-ol-20,21-dione + NADH + H+
dihydrotestosterone + NADH
androstanediol + NAD+
-
Substrates: substrate for retinol dehydrogenase isoform RDH12, no substrate for isoform RDH13
Products: -
Products: -
?
pregn-4-ene-3,20,21-trione + NADH
21-hydroxy-pregn-4-ene-3,20-dione + NAD+
Ovis aries aries
-
Substrates: i.e. 21-dehydro-11-deoxycorticosterone, only NAD dehydrogenase II
Products: i.e. 21-hydroxy-11-deoxycorticosterone
Products: i.e. 21-hydroxy-11-deoxycorticosterone
?
additional information
?
-
-
Substrates: contrary to the human enzyme, dihydrotestosterone is not a substrate for mouse retinol dehydrogenase isoform RDH12
Products: -
Products: -
?
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
Ovis aries aries
-
Substrates: -
Products: i.e. cortisol
Products: i.e. cortisol
?
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
Ovis aries aries
-
Substrates: i.e. 21-dehydrocortisol, transfer of the hydrogen to the 21-pro-S position of cortisol
Products: -
Products: -
?
5beta-pregnane-3alpha,21-diol-20-one + NAD+
5beta-pregnane-3alpha-ol-20,21-dione + NADH + H+
-
Substrates: selective for the pro-S position
Products: -
Products: -
?
5beta-pregnane-3alpha,21-diol-20-one + NAD+
5beta-pregnane-3alpha-ol-20,21-dione + NADH + H+
-
Substrates: selective for the pro-S position
Products: -
Products: -
?
