1.1.1.147: 16alpha-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 16alpha-hydroxysteroid dehydrogenase, go to the full flat file.
Reaction
Synonyms
16alpha-hydroxy steroid dehydrogenase
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.147 - 16alpha-hydroxysteroid dehydrogenase
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REACTION DIAGRAM
16-ketotestosterone + NAD(P)H
16alpha-hydroxytestosterone + NAD(P)+
-
-
-
r
16-oxo-17beta-estradiol + NADH + H+
16alpha-hydroxy-17beta-estradiol + NAD+
-
-
-
-
r
17alpha-estradiol-16-one + NAD(P)H
16alpha-hydroxy-17alpha-estradiol + NAD(P)+
-
best substrate tested, changing configuration or oxidation state of the neighboring oxygen substituent at C-17 increases the rate of reduction
-
r
3-hydroxy-estra-1,3,5(10)-triene-16,17-dione + NAD(P)H + H+
3,16alpha-dihydroxy-estra-1,3,5(10)-triene-17-one + NAD(P)+
-
-
-
r
3beta,17beta-dihydroxy-androst-5-en-16-one + NAD(P)H
3beta,16alpha,17beta-trihydroxyandrost-5-ene + NAD(P)+
-
low activity
-
?
estra-1,3,5(10)-triene-3,16beta,17beta-triol + NAD(P)+
estra-1,3,5(10)-triene-3,17beta-diol-16-one + NAD(P)H
-
-
-
?
estra-1,3,5(10)triene-3,17-beta-diol-16-one + NAD(P)H
estra-1,3,5(10)triene-3,16alpha,17-triol + NAD(P)+
-
low activity
-
r
16alpha-hydroxy-17beta-estradiol + NAD(P)+
-
-
-
r
17beta-estradiol-16-one + NAD(P)H
16alpha-hydroxy-17beta-estradiol + NAD(P)+
-
-
-
r