1.1.1.14: L-iditol 2-dehydrogenase
This is an abbreviated version!
For detailed information about L-iditol 2-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.14
-
1.1.1.14
-
polyols
-
aminotransferase
-
aldose
-
hepatotoxicity
-
fructose
-
necrosis
-
transaminase
-
dehydrogenases
-
bile
-
lens
-
alt
-
sheep
-
bilirubin
-
gamma-glutamyl
-
testicular
-
cataract
-
transpeptidase
-
gluconobacter
-
ccl4
-
acetaminophen
-
tetrachloride
-
centrilobular
-
xylitol
-
oxydans
-
hepatoprotective
-
galactitol
-
apap
-
ribitol
-
acetaminophen-induced
-
diapause
-
pneumotoxicity
-
bromobenzene
-
13-week
-
n-demethylase
-
d-mannitol
-
forestomach
-
hepatotoxicants
-
fructokinase
-
l-sorbose
-
aminopyrine
-
glutamic-pyruvic
-
sorbinil
-
medicine
-
agriculture
-
synthesis
- 1.1.1.14
- polyols
- aminotransferase
- aldose
-
hepatotoxicity
- fructose
- necrosis
- transaminase
- dehydrogenases
- bile
- lens
-
alt
- sheep
- bilirubin
-
gamma-glutamyl
- testicular
- cataract
- transpeptidase
- gluconobacter
- ccl4
- acetaminophen
-
tetrachloride
-
centrilobular
- xylitol
- oxydans
-
hepatoprotective
- galactitol
- apap
- ribitol
-
acetaminophen-induced
-
diapause
-
pneumotoxicity
- bromobenzene
-
13-week
- n-demethylase
- d-mannitol
-
forestomach
-
hepatotoxicants
- fructokinase
- l-sorbose
- aminopyrine
-
glutamic-pyruvic
- sorbinil
- medicine
- agriculture
- synthesis
Reaction
Synonyms
ADH, D-sorbitol dehydrogenase, dehydrogenase, L-iditol, Dgeo_2865, glucitol dehydrogenase, GoSCR, L-iditol 2-dehydrogenase, L-iditol dehydrogenase (sorbitol), L-iditol:NAD oxidoreductase, L-iditol:NAD+ 5-oxidoreductase, LeSDH, MdSDH5, More, NAD+-dependent sorbitol dehydrogenase, NAD-dependent polyol dehydrogenase, NAD-dependent sorbitol dehydrogenase, NAD-SDH, NAD-sorbitol dehydrogenase, PDH-11300, polyol dehydrogenase, Protein tms1, SDH, SldA, SLDH, SOR, Sor1, Sor2, sorbitol dehydrogenase, sorbitol dehydrogenase 1, sorbitol dehydrogenase 2, sorbitol related enzyme, SORD
ECTree
Advanced search results
Inhibitors
Inhibitors on EC 1.1.1.14 - L-iditol 2-dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
2-methyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
i.e. SDI-157
CP-642,931
-
a potent and specific sorbitol dehydrogenase inhibitor, rmacokinetics, biomarker pharmacodynamics, and safety analysis, overview. The inhibitor is rapidly absorbed through the oral route and effectively inhibits SDH. However, the drug is not well tolerated due to adverse neuromuscular effects. The inhibitor alters the red blood cell sorbitol dehydrogenase activity after oral administration
dithioerythritol
-
protection at low concentration, inhibition at high concentration, 100 mM
DTT
-
competitive and noncompetitive with respect to D-sorbitol and NAD+, respectively
-
i.e. SDI-158
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
i.e. SDI-158 or CP-166,572
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
-
i.e. SDI-158, inhibition mechanism, dissociation constants of enzyme-inhibitor complex at various pH values
2-hydroxymethyl-4-(4-N,N-dimethylaminosulfonyl-1-piperazino)pyrimidine
-
i.e. SDI-158
-
strong effect on sorbitol oxidation, slight effect on fructose reduction, ZnSO4 reverses inhibition
-
protection at low concentration, inhibition at high concentration, 100 mM
iodoacetate
-
strong effect on sorbitol oxidation, weaker effect on fructose reduction
additional information
-
inhibition mechanism, poor inhibitors are 3,4-dihydroxyphenyl-ethandiol, imidazole, isobutyramide, and urea
-