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(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
3-oxoacyl-[acyl-carrier protein] + NADPH + H+
beta-oxidation pathway
-
-
?
1,1,1-trifluoroacetone + NADPH
? + NADP+
792% relative activity compared to acetophenone
-
-
?
2',3',4',5',6'-pentafluoroacetophenone + NADPH
? + NADP+
3023% relative activity compared to acetophenone
-
-
?
2-octanone + NADPH
? + NADP+
15% relative activity compared to acetophenone
-
-
?
3'-fluoroacetophenone + NADPH
? + NADP+
100% relative activity compared to acetophenone
-
-
?
3-hydroxydecanoyl-N-acetylcysteamine + NADP+
3-oxodecanoyl-N-acetylcysteamine + NADPH + H+
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
3-oxoacyl-[acyl-carrier protein] + NADPH
3-hydroxyacyl-[acyl-carrier protein] + NADP+
3-oxoacyl-[acyl-carrier protein] + NADPH + H+
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
3-oxobutyryl-[acyl-carrier protein] + NADPH
(R)-3-hydroxybutyryl-[acyl-carrier protein] + NADP+
3-oxodecanoyl-CoA + NADPH
(R)-3-hydroxydecanoyl-CoA + NADP+
3-oxodecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxydecanoyl-[acyl-carrier protein] + NADP+
3-oxododecanoyl-CoA + NADPH
(R)-3-hydroxydodecanoyl-CoA + NADP+
3-oxododecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxydodecanoyl-[acyl-carrier protein] + NADP+
3-oxohexadecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxyhexadecanoyl-[acyl-carrier protein] + NADP+
3-oxohexanoyl-CoA + NADH + H+
(3R)-3-hydroxyhexanoyl-CoA + NAD+
3-oxohexanoyl-CoA + NADPH
(R)-3-hydroxyhexanoyl-CoA + NADP+
3-oxohexanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxyhexanoyl-[acyl-carrier protein] + NADP+
3-oxooctanoyl-CoA + NADPH
(R)-3-hydroxyoctanoyl-CoA + NADP+
3-oxooctanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxyoctanoyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxotetradecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
4'-chloroacetophenone + NADPH
? + NADP+
115% relative activity compared to acetophenone
-
-
?
4'-fluoroacetophenone + NADPH
? + NADP+
62% relative activity compared to acetophenone
-
-
?
9,10-phenanthrene quinone + NADH + H+
?
-
-
-
?
9,10-phenanthrene quinone + NADPH + H+
?
low activity with NADPH
-
-
?
a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
acetoacetyl-CoA + NADH + H+
?
-
-
-
?
acetoacetyl-CoA + NADPH
3-hydroxybutyryl-CoA + NADP+
acetoacetyl-CoA + NADPH
? + NADP+
-
wild-type shows less activity with acetoacetyl-CoA than with acetoacetyl-[acyl-carrier protein]
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
acetoacetyl-CoA + NADPH + H+
?
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
acetoacetyl-N-acetylcysteamine + NADPH + H+
D-3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
-
-
-
r
acetoacetyl-N-cysteamine + NADPH
D-3-hydroxybutyryl-N-cysteamine + NADP+
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
acetophenone + NADPH
? + NADP+
100% relative activity
-
-
?
alpha-chloroacetophenone + NADPH
? + NADP+
1885% relative activity compared to acetophenone
-
-
?
beta-ketoacyl-[acyl-carrier protein] + NADPH
beta-hydroxyacyl-[acyl-carrier protein] + NADP+
beta-ketoacyl-[acyl-carrier protein] + NADPH + H+
beta-hydroxyacyl-[acyl-carrier protein] + NADP+
beta-ketobutyryl-CoA + NADPH
beta-hydroxybutyryl-CoA + NADP+
-
complementation of Escherichia coli fabG mutant with Lactobacillus lactis fabG genes shows that fabG1 encodes a functional beta-ketoacyl ACP reductase and fabG2 encodes an enzyme that has activity with the model substrate beta-ketobutyryl-CoA, but lacks the ability to support fatty acid synthesis both in vivo and in vitro
-
-
?
ethyl 4-chloroacetoacetate + NADPH
? + NADP+
29454% relative activity compared to acetophenone
-
-
?
ethyl acetoacetate + NADPH
? + NADP+
-
-
-
-
?
ethyl acetoacetate + NADPH
ethyl 3-hydroxybutyrate + NADP+
ethylbenzoylacetate + NADPH
? + NADP+
892% relative activity compared to acetophenone
-
-
?
methyl acetoacetate + NADPH
? + NADP+
-
is not a good substrate as ethyl acetoacetate
-
-
?
propiophenone + NADPH
? + NADP+
123% relative activity compared to acetophenone
-
-
?
propyl acetoacetate + NADPH
? + NADP+
-
as substrate it is limited to its weak solubility
-
-
?
additional information
?
-
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
belongs to family of short-chain alcohol dehydrogenases (SDR) with catalytic triade Ser154, Tyr167 and Lys171, catalytic mechanism
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
enzyme is part of the dissociable fatty acid synthase type II multienzyme complex for de novo synthesis of fatty acids from acetyl-CoA and malonyl-CoA
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
first reduction step of fatty acid synthase
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
enzyme in fatty acid synthesis
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
enzyme in fatty acid synthesis
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
r
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
r
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
pH 6.0-7.0, equilibrium almost completely favors formation of the beta-hydroxyacyl ACP derivatives
product is the D-(-)-stereoisomer
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
first reduction step of fatty acid synthase
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
first reduction step of fatty acid synthase
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
r
3-oxoacyl-[acyl-carrier protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
enzyme in fatty acid synthesis
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH
3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
r
3-oxoacyl-[acyl-carrier protein] + NADPH
3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
r
3-oxoacyl-[acyl-carrier protein] + NADPH
3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
cooperative transitions in the enzyme due to cofactor and [acyl-carrier-protein] binding
-
-
r
3-oxoacyl-[acyl-carrier protein] + NADPH + H+
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
?
3-oxoacyl-[acyl-carrier protein] + NADPH + H+
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxobutyryl-[acyl-carrier protein] + NADPH
(R)-3-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
weak activity
-
-
?
3-oxobutyryl-[acyl-carrier protein] + NADPH
(R)-3-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
weak activity
-
-
?
3-oxodecanoyl-CoA + NADPH
(R)-3-hydroxydecanoyl-CoA + NADP+
-
-
-
-
?
3-oxodecanoyl-CoA + NADPH
(R)-3-hydroxydecanoyl-CoA + NADP+
-
-
-
?
3-oxodecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxydecanoyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxodecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxydecanoyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxododecanoyl-CoA + NADPH
(R)-3-hydroxydodecanoyl-CoA + NADP+
-
-
-
-
?
3-oxododecanoyl-CoA + NADPH
(R)-3-hydroxydodecanoyl-CoA + NADP+
-
-
-
?
3-oxododecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxydodecanoyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxododecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxydodecanoyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxohexadecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxyhexadecanoyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxohexadecanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxyhexadecanoyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
3-oxohexanoyl-CoA + NADH + H+
(3R)-3-hydroxyhexanoyl-CoA + NAD+
-
-
-
?
3-oxohexanoyl-CoA + NADH + H+
(3R)-3-hydroxyhexanoyl-CoA + NAD+
-
-
-
?
3-oxohexanoyl-CoA + NADPH
(R)-3-hydroxyhexanoyl-CoA + NADP+
-
-
-
-
?
3-oxohexanoyl-CoA + NADPH
(R)-3-hydroxyhexanoyl-CoA + NADP+
-
-
-
?
3-oxohexanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxyhexanoyl-[acyl-carrier protein] + NADP+
-
weak activity
-
-
?
3-oxohexanoyl-[acyl-carrier protein] + NADPH
(R)-3-hydroxyhexanoyl-[acyl-carrier protein] + NADP+
-
weak activity
-
-
?
3-oxooctanoyl-CoA + NADPH
(R)-3-hydroxyoctanoyl-CoA + NADP+
-
-
-
-
?
3-oxooctanoyl-CoA + NADPH
(R)-3-hydroxyoctanoyl-CoA + NADP+
numerous residues trigger steric hindrance to the binding of NADPH and substrate. Upon NADPH binding, these residues are pushed away from the active site, allowing the enzyme to adopt an open conformation. The transition from an NADPH-bound to an NADP+-bound form is likely to facilitate release of the product
-
-
?
3-oxooctanoyl-CoA + NADPH
(R)-3-hydroxyoctanoyl-CoA + NADP+
numerous residues trigger steric hindrance to the binding of NADPH and substrate. Upon NADPH binding, these residues are pushed away from the active site, allowing the enzyme to adopt an open conformation. The transition from an NADPH-bound to an NADP+-bound form is likely to facilitate release of the product
-
-
?
3-oxooctanoyl-CoA + NADPH
(R)-3-hydroxyoctanoyl-CoA + NADP+
-
-
-
?
a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
r
acetoacetyl-CoA + NADPH
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
r
acetoacetyl-CoA + NADPH
3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH
3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
numerous residues trigger steric hindrance to the binding of NADPH and substrate. Upon NADPH binding, these residues are pushed away from the active site, allowing the enzyme to adopt an open conformation. The transition from an NADPH-bound to an NADP+-bound form is likely to facilitate release of the product
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
numerous residues trigger steric hindrance to the binding of NADPH and substrate. Upon NADPH binding, these residues are pushed away from the active site, allowing the enzyme to adopt an open conformation. The transition from an NADPH-bound to an NADP+-bound form is likely to facilitate release of the product
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
?
low activity with NADPH
-
-
?
acetoacetyl-CoA + NADPH + H+
?
-
-
-
?
acetoacetyl-CoA + NADPH + H+
?
-
-
-
?
acetoacetyl-CoA + NADPH + H+
?
-
-
-
?
acetoacetyl-CoA + NADPH + H+
?
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
r
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-N-cysteamine + NADPH
D-3-hydroxybutyryl-N-cysteamine + NADP+
-
-
-
-
?
acetoacetyl-N-cysteamine + NADPH
D-3-hydroxybutyryl-N-cysteamine + NADP+
-
-
-
-
?
acetoacetyl-N-cysteamine + NADPH
D-3-hydroxybutyryl-N-cysteamine + NADP+
-
-
-
-
?
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
-
-
-
?
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
much greater specificity for acetoacetyl-ACP than for either of the model substrates acetoacetyl-CoA or acetoacetyl-N-acetylcysteamine
-
-
?
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
-
-
-
?
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
-
-
-
?
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
-
-
r
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
-
-
r
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
-
-
-
?
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
much greater specificity for acetoacetyl-ACP than for either of the model substrates acetoacetyl-CoA or acetoacetyl-N-acetylcysteamine
-
-
?
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
Arg187 and Arg230 are critical residues for the FabG-acyl-carrier protein interactions, significance of the positively charged/hydrophobic patch located adjacent to the active site cavities of FabG for interactions with acyl carrier protein
-
-
?
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
-
-
-
?
acetoacetyl-[acyl-carrier protein] + NADPH
D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
-
-
r
beta-ketoacyl-[acyl-carrier protein] + NADPH
beta-hydroxyacyl-[acyl-carrier protein] + NADP+
-
first reductive step in the elongation cycle of fatty acid biosynthesis
-
-
?
beta-ketoacyl-[acyl-carrier protein] + NADPH
beta-hydroxyacyl-[acyl-carrier protein] + NADP+
-
first reductive step in the elongation cycle of fatty acid biosynthesis
-
-
?
beta-ketoacyl-[acyl-carrier protein] + NADPH + H+
beta-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
?
beta-ketoacyl-[acyl-carrier protein] + NADPH + H+
beta-hydroxyacyl-[acyl-carrier protein] + NADP+
-
-
-
?
ethyl acetoacetate + NADPH
ethyl 3-hydroxybutyrate + NADP+
-
-
-
-
?
ethyl acetoacetate + NADPH
ethyl 3-hydroxybutyrate + NADP+
-
-
-
-
?
additional information
?
-
-
animals, yeast and Mycobacteria have fatty acid synthetase containing all the individual activities on one or two multifunctional polypeptide chains, plants and most bacterial systems, including E. coli, possess individual monofunctional enzymes and a separate acyl carrier protein
-
-
?
additional information
?
-
-
only D-(-) isomer is oxidized
-
-
?
additional information
?
-
-
beta-ketoacyl thioesters of CoA and pantetheine metabolized at slower rates
-
-
?
additional information
?
-
-
equally active on beta-ketoacyl-ACP derivatives of C4 to C16
-
-
?
additional information
?
-
-
broad specificity for chain length of substrates
-
-
?
additional information
?
-
-
broad specificity for chain length of substrates
-
-
?
additional information
?
-
-
L-isomer completely inactive
-
-
?
additional information
?
-
-
L-isomer completely inactive
-
-
?
additional information
?
-
-
catalyzes also the reduction of the beta-keto group of unsaturated acyl chains during biosynthesis of unsaturated fatty acids
-
-
?
additional information
?
-
-
FabG substrate specificity overview
-
-
?
additional information
?
-
-
FabG1 is responsible for the first reductive step of the fatty acid synthetic cycle. FabG2 is inactive in fatty acid synthesis
-
-
?
additional information
?
-
-
FabG1 is able to act on shorter (C4) acyl substrates
-
-
?
additional information
?
-
FabG1 is able to act on shorter (C4) acyl substrates
-
-
?
additional information
?
-
FabG1 is able to act on shorter (C4) acyl substrates
-
-
?
additional information
?
-
FabG1 is able to act on shorter (C4) acyl substrates
-
-
?
additional information
?
-
no activity with NADH
-
-
?
additional information
?
-
-
no activity with NADH
-
-
?
additional information
?
-
no activity with NADH
-
-
?
additional information
?
-
-
animals, yeast and Mycobacteria have fatty acid synthetase containing all the individual activities on one or two multifunctional polypeptide chains, plants and most bacterial systems, including E. coli, possess individual monofunctional enzymes and a separate acyl carrier protein
-
-
?
additional information
?
-
-
the beta-ketoacyl acyl carrier protein reductase activity of the fatty acid biosynthetic pathway is a determining factor of 3-oxo-homoserine lactone acyl chain lengths
-
-
?
additional information
?
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the enzyme is essential in the rhamnolipid biosynthetic pathway of Pseudomonas aeruginosa
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?
additional information
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fabG overexpression tends to depress the biosynthesis of medium-chain-length polyhydroxyalkanoate due to the reversible conversion of (R)-3-hydroxyalkanoate monomer units into 3-ketoacyl-CoA
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additional information
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fabG overexpression tends to depress the biosynthesis of medium-chain-length polyhydroxyalkanoate due to the reversible conversion of (R)-3-hydroxyalkanoate monomer units into 3-ketoacyl-CoA
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?
additional information
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FabG substrate specificity overview
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additional information
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FabG substrate specificity overview
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additional information
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L-isomer completely inactive
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additional information
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no activity with acetoacetyl-CoA
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