EC Number   |
Protein Variants |
Reference |
|---|
    1.5.1.20 | A1298C |
decreased enzyme activity |
392168 |
| 1.5.1.20 | A1298C |
high level of enzyme activity, retains 40% of its activity after 20 min at 55°C |
392166 |
| 1.5.1.20 | A1298C |
MTHFR C677T/C677T and A1298C/A1298C, but not factor V-Leiden, genotypes are associated with stroke. The C677T but not A1298C MTHFR mutation is associated with elevated homocysteine levels in patients and control subjects |
699849 |
| 1.5.1.20 | A1298C |
natural polymorphism, not associated with colorectal cancer risk. Patients with 1298CC and AC genotypes exhibit worse survival than those with the wild-type genotype. Variant C allele of A1298C affects negatively the response to 5-fluorouracil-based chemotherapy |
712182 |
| 1.5.1.20 | A1298C |
natural polymorphism. Mutation is not associated with increased toxicity of methotrexate |
699836 |
| 1.5.1.20 | A177V |
crystallization data |
672154 |
| 1.5.1.20 | A177V |
enzyme is thermolabile |
392164 |
| 1.5.1.20 | A177V |
enzyme with decreased affinity for its FAD cofactor |
437725 |
| 1.5.1.20 | A177V |
mutation does not affect Km or kcat values for NADH or 5,10-methylenetetrahydrofolate |
392163 |
| 1.5.1.20 | A177V |
the mutation causes loss of the essential cofactor |
689078 |
