EC Number   |
Protein Variants |
Reference |
|---|
    1.15.1.1 | A16V |
naturally occuring ala16val polymorphism genotyping, overview |
716197 |
| 1.15.1.1 | A4V |
mutation causing familial amyotrophic lateral scerosis, 30% of wild-type activity, 1.06 atoms of copper and 1.43 atoms of zinc per subunit |
675341 |
| 1.15.1.1 | C111S |
site-directed mutagenesis, the mutant has 1.07 copper and 1.18 zinc per subunit |
688384 |
| 1.15.1.1 | C140S |
catalytic efficiency similar to wild-type, product inhibition is less than in wild-type |
673565 |
| 1.15.1.1 | C140S/Q143A |
catalysis does not follow Michaelis-Menten kinetics, substrate inhibition with KI-value of 0.06 mM |
673565 |
| 1.15.1.1 | D124N |
site-directed mutagenesis, the mutant has 0.93 copper and 0.03 zinc per subunit |
688384 |
| 1.15.1.1 | D124N/C111S |
site-directed mutagenesis, the mutant has 0.93 copper and 0.03 zinc per subunit |
688384 |
| 1.15.1.1 | D83S |
site-directed mutagenesis, the mutant has 0.93 copper and 0.08 zinc per subunit |
688384 |
| 1.15.1.1 | D83S/C111S |
site-directed mutagenesis, the mutant has 0.93 copper and 0.08 zinc per subunit |
688384 |
| 1.15.1.1 | D90A |
Cu,Zn-SOD, mutant found in familial amyotrophic lateral sclerosis, activity similar compared to native and recombinant wild-type, but enhanced OH- generating activity, mutant is more sensitive to inhibition by copper-chelators |
-, 438175 |
