EC Number   |
Protein Variants |
Reference |
|---|
    1.1.1.51 | A231Y |
mutation abolishes and decreases by 14.6fold the initial rates for steroid oxidation and reduction, respectively. Residue A231 allows the correct accommodation and conversion of steroids |
725824 |
| 1.1.1.51 | C310F |
site-directed mutagenesis, the mutation, in analogy to enzyme AKR1C34 sequence, does not affect the enzyme activity of AKR1C35 |
740637 |
| 1.1.1.51 | more |
AKR1C3 siRNA reduces androgen receptor signaling in VCaP cells |
740329 |
| 1.1.1.51 | more |
construction of a betahsd knockout mutant of Comamonas testosteroni by homologous integration, and preparation of 3,17b-HSD gene high expression mutant |
-, 740292 |
| 1.1.1.51 | more |
construction of transcriptional repressor PhaR knockout mutants M6 of Comamonas testosteroni, the mutants grow better than wild-type Comamonas testosteroni in the presence of 1 mM testosterone, 0.5 mM estradiol or 0.5 mM cholesterol. phaR Knockout mutants M6 cells are inhibited by estradiol and cholesterol, this inhibition is stronger in M6 cells than in wild-type Comamonas testosteroni |
-, 740307 |
| 1.1.1.51 | V54A |
site-directed mutagenesis, the mutation, in analogy to enzyme AKR1C34 sequence, impairs the 3beta-hydroxysteroid dehydrogenase activity of AKR1C35 |
740637 |
