EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
2.1.2.1 | 0.000009 |
- |
(+/-)-methyl 5-[3-(6-amino-5-cyano-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazol-4-yl)-5-cyanophenyl]thiophene-2-carboxylate |
at pH 7.0, temperature not specified in the publication |
757384 |
2.1.2.1 | 0.00006 |
- |
methyl 5-[3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]thiophene-2-carboxylate |
at pH 7.0, temperature not specified in the publication |
757384 |
2.1.2.1 | 0.00017 |
- |
benzyl 5-[3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]thiophene-2-carboxylate |
at pH 7.0, temperature not specified in the publication |
757384 |
2.1.2.1 | 0.00021 |
- |
6-amino-4-(5-cyano-3'-fluoro[1,1'-biphenyl]-3-yl)-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile |
at pH 7.0, temperature not specified in the publication |
757384 |
2.1.2.1 | 0.00021 |
- |
methyl 3'-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5'-chloro[1,1'-biphenyl]-4-carboxylate |
at pH 7.0, temperature not specified in the publication |
757384 |
2.1.2.1 | 0.00022 |
- |
3'-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5'-cyano[1,1'-biphenyl]-3-carboxylic acid |
at pH 7.0, temperature not specified in the publication |
757384 |
2.1.2.1 | 0.00027 |
- |
5-[3-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]-N,N-dimethylthiophene-2-carboxamide |
at pH 7.0, temperature not specified in the publication |
757384 |
2.1.2.1 | 0.00029 |
- |
6-amino-4-(3,5-dichlorophenyl)-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile |
at pH 7.0, temperature not specified in the publication |
757384 |
2.1.2.1 | 0.00037 |
- |
(4R)-6-amino-4-(5-cyano-3'-fluoro[1,1'-biphenyl]-3-yl)-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile |
at pH 7.0, temperature not specified in the publication |
757384 |
2.1.2.1 | 0.00037 |
- |
methyl 5-[3-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]thiophene-2-carboxylate |
at pH 7.0, temperature not specified in the publication |
757384 |