EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
1.1.1.34 | 0.00000011 |
- |
(3R,5R)-7-[5-(4-carboxy-benzylcarbamoyl)-ethyl-3-(4-fluorophenyl)-4-methyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoicacid disodium salt |
37°C, hepatocytes |
685520 |
1.1.1.34 | 0.00000015 |
- |
(3R,5R)-7-[5-benzylcarbamoyl-3-(4-fluoro-phenyl)-1-isopropyl-4-pyridin-2-yl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoicacid |
37°C, hepatocytes |
685520 |
1.1.1.34 | 0.00000017 |
- |
(3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-phenylcarbamoyl-4-pyridin-2-yl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid sodium salt |
37°C, hepatocytes |
685520 |
1.1.1.34 | 0.0000002 |
- |
(3R,5R)-7-[5-[(4-cyanobenzyl)carbamoyl]-3-(4-fluorophenyl)-1-(1-methylethyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoate |
inhibition of purified enzyme |
685581 |
1.1.1.34 | 0.00000023 |
- |
rosuvastatin |
37°C, hepatocytes |
685520 |
1.1.1.34 | 0.00000024 |
- |
(3R,5R)-7-[1-ethyl-3-(4-fluorophenyl)-5-(4-methoxybenzylcarbamoyl)-4-methyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid sodium salt |
37°C, hepatocytes |
685520 |
1.1.1.34 | 0.00000028 |
- |
(3R,5R)-7-[1-ethyl-3-(4-fluorophenyl)-5-(4-methoxycarbonyl-benzylcarbamoyl)-4-methyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid sodium salt |
37°C, hepatocytes |
685520 |
1.1.1.34 | 0.00000029 |
- |
(3R,5R)-7-[1-ethyl-3-(4-fluorophenyl)-4-methyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoicacid sodium salt |
37°C, hepatocytes |
685520 |
1.1.1.34 | 0.0000003 |
- |
7-[5-[(4-carbamoylphenyl)carbamoyl]-3-(4-fluorophenyl)-1-(1-methylethyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoate |
inhibition of purified enzyme |
685581 |
1.1.1.34 | 0.0000003 |
- |
7-[5-[(4-carboxyphenyl)carbamoyl]-3-(4-fluorophenyl)-1-(1-methylethyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoate |
inhibition of purified enzyme |
685581 |