EC Number   |
Subunits |
Reference |
|---|
    1.5.1.20 | ? |
napA encodes the catalytic subunit, the napB gene product is a soluble dihaem c and the napC gene product is a membrane-anchored tetrahaem c-type cytochrome, napE encodes a transmembrane protein of unknown function, the napD gene product is a soluble protein which is assumed to play a role in the maturation of NapA |
-, 659882 |
| 1.5.1.20 | ? |
x * 34800, calculated |
674719 |
| 1.5.1.20 | ? |
x * 66400, calculated from the nucleotide sequence |
437724 |
| 1.5.1.20 | ? |
x * 69000, met9, SDS-PAGE, x *72100, met11, SDS-PAGE |
657415 |
| 1.5.1.20 | ? |
x * 77000, SDS-PAGE, x * 70000, SDS-PAGE of MTHFR mutant c.523G>A or mutant c.1166G>A |
713042 |
| 1.5.1.20 | dimer |
- |
437725 |
| 1.5.1.20 | dimer |
2 * 66000, SDS-PAGE |
437724 |
| 1.5.1.20 | dimer |
2 * 75000, SDS-PAGE and inhibition studies |
392157 |
| 1.5.1.20 | dimer |
2 * 77000 |
392164 |
| 1.5.1.20 | dimer |
an asymmetric MTHFR dimer with inter-domain flexibility. The extensive linker connects and interacts with both domains, the N-terminal catalytic domain (aa 40-337) consisting of an 8alpha/8beta TIM barrel, adorned with three extra alpha-helices, and the C-terminal regulatory domain (aa 363-644) making up a fold of two five-stranded beta-sheets arranged side-by-side in the core, flanked by a number of alpha-helices |
761998 |
