EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.49 | (R)-isosalsoline + methyl group donor |
- |
Bos taurus |
N-methyl-(R)-isosalsoline + demethylated methyl group donor |
N-methyl-(R)-isosalsoline is enzymatically formed in liver and can be transported into the brain from blood, it may act as neurotransmitter |
? |
2.1.1.49 | more |
two N-methyltransferases A and B with very broad but overlapping substrate specificity for primary and secondary amines, lipophilic substrates, overview poor substrates, no substrates: N-acetylserotonine, 4-aminoacetophenone, 4-aminophenol, benzamide, 4-chloroaniline, deoxyepinephrine, 1,4-diaminobutane, dopamine, 1-ethanol-2-amine, ethylenediamine, histamine, histidine methylester, 3-hydroxytryptamine, indole, pyrrole, methylamine, N-methyldopamine, nicotinamide, octopamine, phenylalanine, phenylethanolamine, theophylline, tryptophan, tyrosine, N,N-dimethyltryptamine |
Oryctolagus cuniculus |
? |
- |
? |
2.1.1.49 | more |
two N-methyltransferases A and B with very broad but overlapping substrate specificity for primary and secondary amines, lipophilic substrates, overview poor substrates, no substrates: N-acetylserotonine, 4-aminoacetophenone, 4-aminophenol, benzamide, 4-chloroaniline, deoxyepinephrine, 1,4-diaminobutane, dopamine, 1-ethanol-2-amine, ethylenediamine, histamine, histidine methylester, 3-hydroxytryptamine, indole, pyrrole, methylamine, N-methyldopamine, nicotinamide, octopamine, phenylalanine, phenylethanolamine, theophylline, tryptophan, tyrosine, N,N-dimethyltryptamine |
Oryctolagus cuniculus New Zealand |
? |
- |
? |
2.1.1.49 | S-adenosyl-L-methionine + 1,2,3,4-tetrahydroisoquinoline |
amine N-methyltransferase A |
Bos taurus |
S-adenosyl-L-homocysteine + N-methyl-1,2,3,4-tetrahydroisoquinoline |
- |
? |
2.1.1.49 | S-adenosyl-L-methionine + 5-methyloxytryptamine |
higher activity with transferase A |
Oryctolagus cuniculus |
? |
- |
? |
2.1.1.49 | S-adenosyl-L-methionine + 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline |
substrate with highest apparent kcat |
Oryctolagus cuniculus |
? |
- |
? |
2.1.1.49 | S-adenosyl-L-methionine + alpha-N-methyltryptamine |
- |
Oryctolagus cuniculus |
S-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine |
- |
? |
2.1.1.49 | S-adenosyl-L-methionine + alpha-N-methyltryptamine |
- |
Oryctolagus cuniculus |
S-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine |
no methylation of indolic nitrogen |
? |
2.1.1.49 | S-adenosyl-L-methionine + alpha-N-methyltryptamine |
- |
Rattus norvegicus |
S-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine |
N,N-dimethyltryptamine as product |
? |
2.1.1.49 | S-adenosyl-L-methionine + alpha-N-methyltryptamine |
- |
Oryctolagus cuniculus New Zealand |
S-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine |
no methylation of indolic nitrogen |
? |