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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1693 S-adenosyl-L-methionine + tricetin overall reaction Triticum aestivum 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1693 S-adenosyl-L-methionine + tricetin TaOMT1 (TaCOMT1) catalyzes the sequential methylation of tricetin to its 3'-O-monomethyl-derivative (selgin), 3',5'-O-dimethyl-derivative (tricin) and 3',4',5'-O-trimethyl derivative. 3',5'-O-dimethyltricetin appears to be the major reaction product. The enzyme also catalyzes methylation of luteolin, quercetin and eriodictyol Triticum aestivum 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1693 S-adenosyl-L-methionine + tricetin the enzyme catalyzes three sequential O-methylations, forming 3'-O-methyltricetin, 3',5'-dimethyltricetin and 3',4',5'-O-trimethyltricetin. Tricetin is the preferred substrate. Also catalyzes the methylation of 5-hydroxyferulic acid, luteolin, quercetin, eriodyctiol, quercetagetin, taxifolin, gossypetin and myricetin. TaOMT2 is a flavonoid, B-ring-specific O-methyltransferase with a preference for flavones > dihydroflavones > flavonols that possess at least two, B-ring hydroxyl groups Triticum aestivum 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.169more stepwise methylation of tricetin involving deprotonation of its hydroxyl groups by a His262-Asp263 pair followed by nucleophilic attack of SAM-methyl groups, substrate binding is mediated by an extensive network of H-bonds and van der Waals interactions, residue Val309 determines substrate specificity for tricetin and may define the evolutionary differences between the two closely related proteins, COMT and flavone OMT, molecular modeling, overview Triticum aestivum ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.169more structure-function relationships, homology modeling and molecular docking using MsCOMT crystal structure, PDB ID 1KYZ, overview Triticum aestivum ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.169S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin - Triticum aestivum S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.169S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin the enzyme catalyzes three sequential O-methylations, forming 3'-O-methyltricetin, 3',5'-dimethyltricetin and 3',4',5'-O-trimethyltricetin. Tricetin is the preferred substrate Triticum aestivum S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.169S-adenosyl-L-methionine + 3'-O-methyltricetin - Triticum aestivum S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.169S-adenosyl-L-methionine + 3'-O-methyltricetin the enzyme catalyzes three sequential O-methylations, forming 3'-O-methyltricetin, 3',5'-dimethyltricetin and 3',4',5'-O-trimethyltricetin. Tricetin is the preferred substrate Triticum aestivum S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.169S-adenosyl-L-methionine + 5-hydroxyferulic acid second most preferred substrate with 78% activity compared to tricetin Triticum aestivum ? - ?
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