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EC Number
Source Tissue
Commentary
Reference
1.3.5.2
brain
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713150
1.3.5.2
brain
presence of enzymatically active DHODH in many regions of the central nervous system, albeit at different intensities. High levels of both DHODH activity and immunoreactivity are observed in the neocortex, hippocampus, spinal cord and choroid plexus. Lower levels are seen in the cerebellum, and only marginal expression in brain stem
713150
1.3.5.2
brain stem
very low enzyme level
713150
1.3.5.2
brain stem
very low level both of expression and activity
713150
1.3.5.2
carcinoma cell
colon cancer has a high expression of DHODH and HCT-116 is sensitive to DHODH inhibition, while DHODH is not overexpressed in pancreatic cancer
763351
1.3.5.2
cell culture
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391229
1.3.5.2
central nervous system
regiospecific distribution of DHODH, immunohistochemic analysis, overview
713150
1.3.5.2
cerebellum
low enzyme level
713150
1.3.5.2
cerebellum
low level both of expression and activity
713150
1.3.5.2
cerebral cortex
high enzyme level
713150
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