EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.1 | alcohol dehydrogenase |
hepatoma cell |
- |
686331 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
hepatoma cell |
- |
762356 |
1.1.1.205 | IMP dehydrogenase |
hepatoma cell |
- |
347916 |
1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase |
hepatoma cell |
- |
761287 |
1.1.1.271 | GDP-L-fucose synthase |
hepatoma cell |
the enzyme is aberrantly upregulated in human hepatoma |
762887 |
1.1.1.300 | NADP-retinol dehydrogenase |
hepatoma cell |
reduced RDH11 expression level compared to hepatocytes |
761488 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
hepatoma cell |
- |
761332 |
1.1.1.41 | isocitrate dehydrogenase (NAD+) |
hepatoma cell |
- |
712180 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
hepatoma cell |
- |
712180 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
hepatoma cell |
- |
725172 |
1.11.1.9 | glutathione peroxidase |
hepatoma cell |
- |
688957 |
1.13.11.53 | acireductone dioxygenase (Ni2+-requiring) |
hepatoma cell |
- |
764433 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
hepatoma cell |
- |
673915, 675183, 675861 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
hepatoma cell |
highly expressed in 4 of 10 hepatocarcinomas, 10-fold activity increase |
439254 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
hepatoma cell |
- |
745949, 756531 |
1.14.11.69 | [histone H3]-trimethyl-L-lysine36 demethylase |
hepatoma cell |
- |
745949 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
hepatoma cell |
overexpression of HO-1 |
-, 687147 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
hepatoma cell |
- |
746433 |
1.14.99.38 | cholesterol 25-monooxygenase |
hepatoma cell |
- |
745051 |
1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase |
hepatoma cell |
- |
698198 |
1.17.4.1 | ribonucleoside-diphosphate reductase |
hepatoma cell |
- |
745050 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
hepatoma cell |
- |
349006 |
1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
hepatoma cell |
- |
-, 742477 |
1.2.1.36 | retinal dehydrogenase |
hepatoma cell |
- |
763150 |
1.2.4.1 | pyruvate dehydrogenase (acetyl-transferring) |
hepatoma cell |
- |
700236 |
1.3.1.21 | 7-dehydrocholesterol reductase |
hepatoma cell |
- |
740913 |
1.4.1.27 | glycine cleavage system |
hepatoma cell |
- |
759374 |
1.4.3.13 | protein-lysine 6-oxidase |
hepatoma cell |
- |
684931 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
hepatoma cell |
- |
392128 |
1.5.8.4 | dimethylglycine dehydrogenase |
hepatoma cell |
- |
743378 |
1.8.1.9 | thioredoxin-disulfide reductase |
hepatoma cell |
- |
677195 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
hepatoma cell |
MsrB1 is highly expressed in HCC tissues and its expression correlates with the prognoses of patients with HCC after hepatectomy |
765497 |
2.1.1.17 | phosphatidylethanolamine N-methyltransferase |
hepatoma cell |
enzyme form PEMT2 is absent in hepatoma cells growing exponentially in vivo. Both PEMT2 and mRNA appears when cells enter the stationary phase of tumor growth |
485189 |
2.1.1.17 | phosphatidylethanolamine N-methyltransferase |
hepatoma cell |
PEMT2 protein decreases in preneoplastic nodules and virtually disappears in hepatocellular carcinoma |
485195 |
2.1.1.5 | betaine-homocysteine S-methyltransferase |
hepatoma cell |
- |
673003 |
2.1.2.5 | glutamate formimidoyltransferase |
hepatoma cell |
DU249 chicken hepatoma cells, contain p60 but no measurable formiminotransferase activity, may be due to the low expression of p60 |
34325 |
2.1.3.3 | ornithine carbamoyltransferase |
hepatoma cell |
- |
757879 |
2.3.1.26 | sterol O-acyltransferase |
hepatoma cell |
- |
486677, 684882 |
2.3.1.42 | glycerone-phosphate O-acyltransferase |
hepatoma cell |
- |
756338 |
2.3.1.48 | histone acetyltransferase |
hepatoma cell |
- |
756850, 757011 |
2.3.1.48 | histone acetyltransferase |
hepatoma cell |
tissue culture cell, HTC cells |
487078 |
2.3.1.57 | diamine N-acetyltransferase |
hepatoma cell |
- |
701662, 757889 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
hepatoma cell |
- |
757883 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
hepatoma cell |
HCC cell, SIRT6 upregulation is quite prevalent in HCC tissues and closely correlated with worse overall survival, disease-relapse free survival, and HCC metastasis |
757530 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
hepatoma cell |
increased SIRT6 expression in HCC, SIRT6 expression pattern and its association with HCC metastasis, overview |
757644 |
2.3.2.2 | gamma-glutamyltransferase |
hepatoma cell |
azo dye-induced |
487913 |
2.3.2.2 | gamma-glutamyltransferase |
hepatoma cell |
primary and Yoshida ascites (AH 13) |
487912 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
hepatoma cell |
- |
759074 |
2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
diethylnitrosamine- or dimethylaminoazobenzene-induced hepatoma, Morris 5123D hepatoma or AH-109A, solid or ascitic |
488363 |
2.4.1.133 | xylosylprotein 4-beta-galactosyltransferase |
hepatoma cell |
- |
704930 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
- |
488370, 637308, 638223, 638224, 638227, 736507 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
7721 cells, activity during cell-cycle |
638226 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
low activity |
638223 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
primary, about 100fold increased activity compared to normal liver tissue |
638223 |
2.4.1.145 | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
- |
722374 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
hepatoma cell |
- |
675946, 759648 |
2.4.1.255 | protein O-GlcNAc transferase |
hepatoma cell |
the level of total O-GlcNAcylation or O-GlcNAc transferase protein is increased in hepatocellular carcinoma |
759542 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
hepatoma cell |
- |
657750, 688952 |
2.4.1.65 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase |
hepatoma cell |
- |
662544 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
hepatoma cell |
- |
489333 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
hepatoma cell |
DAB-induced hepatoma |
489333 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
hepatoma cell |
expression in hepatoma tissues and their surrounding tissues and in tissues with chronic disease, overview |
489339 |
2.4.1.69 | type 1 galactoside alpha-(1,2)-fucosyltransferase |
hepatoma cell |
e.g. hepatoma H35 cells, the enzyme is induced during early stages of chemical hepatocarcinogenesis in parenchymal cells of Fischer 344 rats fed a diet supplemented with 0.03% N-2-acetylaminofluorene, undetectable in normal liver tissue |
489357 |
2.4.1.90 | N-acetyllactosamine synthase |
hepatoma cell |
Hep-G2 cells |
658123 |
2.4.2.10 | orotate phosphoribosyltransferase |
hepatoma cell |
OPRT is involved in early events of invasion of hepatocellular carcinoma cells |
676296 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
hepatoma cell |
- |
735872 |
2.4.2.30 | NAD+ ADP-ribosyltransferase |
hepatoma cell |
- |
736899 |
2.4.2.31 | NAD+-protein-arginine ADP-ribosyltransferase |
hepatoma cell |
- |
638116 |
2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase |
hepatoma cell |
- |
759660, 764855 |
2.5.1.18 | glutathione transferase |
hepatoma cell |
- |
637909, 637921 |
2.5.1.21 | squalene synthase |
hepatoma cell |
- |
658266, 738940 |
2.5.1.22 | spermine synthase |
hepatoma cell |
- |
489869 |
2.5.1.6 | methionine adenosyltransferase |
hepatoma cell |
- |
686924, 686926 |
2.6.1.13 | ornithine aminotransferase |
hepatoma cell |
- |
759413 |
2.6.1.44 | alanine-glyoxylate transaminase |
hepatoma cell |
- |
759686 |
2.6.1.51 | serine-pyruvate transaminase |
hepatoma cell |
- |
759686 |
2.7.1.1 | hexokinase |
hepatoma cell |
- |
704456 |
2.7.1.1 | hexokinase |
hepatoma cell |
type II isozyme |
662531 |
2.7.1.105 | 6-phosphofructo-2-kinase |
hepatoma cell |
- |
761915 |
2.7.1.105 | 6-phosphofructo-2-kinase |
hepatoma cell |
resembles muscle enzyme |
94932 |
2.7.1.107 | diacylglycerol kinase (ATP) |
hepatoma cell |
- |
761306 |
2.7.1.12 | gluconokinase |
hepatoma cell |
- |
762082 |
2.7.1.137 | phosphatidylinositol 3-kinase |
hepatoma cell |
Fao hepatoma cells |
640913 |
2.7.1.171 | protein-fructosamine 3-kinase |
hepatoma cell |
- |
760823 |
2.7.1.171 | protein-fructosamine 3-kinase |
hepatoma cell |
overexpression |
762465 |
2.7.1.48 | uridine/cytidine kinase |
hepatoma cell |
- |
761333 |
2.7.1.48 | uridine/cytidine kinase |
hepatoma cell |
hepatoma 3924A cells, 2fold increase in activity during early log phase of prolifration |
641653 |
2.7.1.48 | uridine/cytidine kinase |
hepatoma cell |
UCK2 is significantly upregulated in hepatocellular carcinoma tissues compared to adjacent normal tissues |
761333 |
2.7.1.48 | uridine/cytidine kinase |
hepatoma cell |
UCKL1 is significantly upregulated in hepatocellular carcinoma tissues compared to adjacent normal tissues |
761333 |
2.7.1.91 | sphingosine kinase |
hepatoma cell |
- |
671356, 673271 |
2.7.10.1 | receptor protein-tyrosine kinase |
hepatoma cell |
- |
490387 |
2.7.10.2 | non-specific protein-tyrosine kinase |
hepatoma cell |
- |
490349, 661445, 661461 |
2.7.10.2 | non-specific protein-tyrosine kinase |
hepatoma cell |
HCC cell |
691651 |
2.7.11.1 | non-specific serine/threonine protein kinase |
hepatoma cell |
- |
491119, 661422, 661900 |
2.7.11.10 | IkappaB kinase |
hepatoma cell |
- |
662516 |
2.7.11.12 | cGMP-dependent protein kinase |
hepatoma cell |
- |
693879 |
2.7.11.13 | protein kinase C |
hepatoma cell |
constitutively active isozyme PKCdelta |
676029 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
hepatoma cell |
- |
664865 |
2.7.11.19 | phosphorylase kinase |
hepatoma cell |
- |
761283 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
hepatoma cell |
- |
660642, 660896, 674730, 760485 |