EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.13.11.31 | arachidonate 12-lipoxygenase |
gastric cancer cell |
12-LOX overexpression |
686330 |
1.14.11.53 | mRNA N6-methyladenine demethylase |
gastric cancer cell |
- |
765411 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
gastric cancer cell |
- |
745752 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
gastric cancer cell |
JMJD2B expression profile in gastric cancer, overview |
752645 |
1.14.11.69 | [histone H3]-trimethyl-L-lysine36 demethylase |
gastric cancer cell |
JMJD2B expression profile in gastric cancer, overview |
752645 |
1.14.17.3 | peptidylglycine monooxygenase |
gastric cancer cell |
- |
438581 |
1.14.19.17 | sphingolipid 4-desaturase |
gastric cancer cell |
- |
744686, 745511 |
1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase |
gastric cancer cell |
- |
698198, 745752 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
gastric cancer cell |
- |
763003 |
1.3.1.1 | dihydropyrimidine dehydrogenase (NAD+) |
gastric cancer cell |
- |
689367 |
2.1.1.357 | [histone H3]-lysine36 N-dimethyltransferase |
gastric cancer cell |
- |
753720 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
gastric cancer cell |
- |
758122 |
2.3.1.48 | histone acetyltransferase |
gastric cancer cell |
- |
703846, 756850 |
2.3.2.23 | E2 ubiquitin-conjugating enzyme |
gastric cancer cell |
quantitative real-time PCR enzyme expression analysis in gastric cancer cell lines, overview |
760224 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
gastric cancer cell |
GCNT3 expression in Epstein-Barr virus (EBV)-associated gastric cancer cells and tissues is lower than in EBV-negative gastric cancer cells (EBVnGC) and tissues, and high expression is significantly associated with advanced tumor-lymph node metastasis. GCNT3 is closely related to the ERK signaling pathway and epithelial mesenchymal transition (EMT), regulating cell proliferation, migration, and invasion |
760226 |
2.4.1.150 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase |
gastric cancer cell |
GCNT3 expression in Epstein-Barr virus (EBV)-associated gastric cancer cells and tissues is lower than in EBV-negative gastric cancer cells (EBVnGC) and tissues, and high expression is significantly associated with advanced tumor-lymph node metastasis. GCNT3 is closely related to the ERK signaling pathway and epithelial mesenchymal transition (EMT), regulating cell proliferation, migration, and invasion |
760226 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
gastric cancer cell |
- |
706072 |
2.4.1.41 | polypeptide N-acetylgalactosaminyltransferase |
gastric cancer cell |
high enzyme expression in tumoral gastric tissue displaying intestinal metaplasia, increased activity compared to normal stomach, di-glycosylates MUC5AC peptide |
489192 |
2.4.1.69 | type 1 galactoside alpha-(1,2)-fucosyltransferase |
gastric cancer cell |
down regulation of alpha1,2-fucosyltransferase activity is associated with human gastric tumorigenesis |
680997 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
gastric cancer cell |
- |
686976 |
2.4.2.10 | orotate phosphoribosyltransferase |
gastric cancer cell |
- |
676270, 685927 |
2.4.2.10 | orotate phosphoribosyltransferase |
gastric cancer cell |
221 specimen, expression profile of the enzyme and its antagonist dihydropyrimidine dehydrogenase both active in 5-fluorouracil metabolism, the enzyme expression levels correlate, overview |
676267 |
2.4.2.10 | orotate phosphoribosyltransferase |
gastric cancer cell |
OPRT levels are high in well differentiated and localized gastric carcinomas and are significantly higher in gastric carcinoma tissue than in normal gastric mucosa |
686922 |
2.4.2.3 | uridine phosphorylase |
gastric cancer cell |
- |
684470 |
2.4.2.4 | thymidine phosphorylase |
gastric cancer cell |
- |
684468, 684476, 688212, 689292 |
2.4.2.4 | thymidine phosphorylase |
gastric cancer cell |
enzyme activity is higher in cancer tiddue than in adjacent normal tissue |
659750 |
2.7.1.105 | 6-phosphofructo-2-kinase |
gastric cancer cell |
- |
737973, 761915 |
2.7.1.137 | phosphatidylinositol 3-kinase |
gastric cancer cell |
- |
708417 |
2.7.1.91 | sphingosine kinase |
gastric cancer cell |
- |
671356 |
2.7.1.94 | acylglycerol kinase |
gastric cancer cell |
high expression level |
662505 |
2.7.10.1 | receptor protein-tyrosine kinase |
gastric cancer cell |
- |
490316, 490356, 490365, 490389, 690303 |
2.7.10.1 | receptor protein-tyrosine kinase |
gastric cancer cell |
gastric cancer |
490371 |
2.7.11.12 | cGMP-dependent protein kinase |
gastric cancer cell |
- |
760502 |
2.7.11.19 | phosphorylase kinase |
gastric cancer cell |
- |
741081 |
2.7.11.22 | cyclin-dependent kinase |
gastric cancer cell |
mRNA levels of CDK7 are statistically overexpressed in gastric cancer cells when compared with matched normal tissues. Upregulation of cyclin-dependent kinase 7 contributes to metastatic properties of gastric cancer. High expression of MMP14 and CDK7 are independent prognostic factors for overall survival in patients with gastric cancer |
761329 |
2.7.2.3 | phosphoglycerate kinase |
gastric cancer cell |
- |
761524 |
2.7.2.3 | phosphoglycerate kinase |
gastric cancer cell |
primary gastric carcinoma, overexpression of PGK1 and its signalling targets may be a expression-pathway in diffuse primary gastric carcinomas promoting peritoneal dissemination and may function as prognostic markers and/or be potential therapeutic targets to prevent the migration of gastric carcinoma cells into the peritoneum |
686031 |
3.1.13.4 | poly(A)-specific ribonuclease |
gastric cancer cell |
poly(A)-specific ribonuclease (PARN) is upregulated in gastric tumor tissues and gastric cancer cell lines MKN28 and AGS, determination of the expression level of PARN in human gastric cancer cells and tissues by quantitative real-time PCR expression analysis |
749952 |
3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
gastric cancer cell |
tissue from patients with sporadic gastric carcinoma |
691598 |
3.2.1.166 | heparanase |
gastric cancer cell |
- |
731867 |
3.4.17.21 | Glutamate carboxypeptidase II |
gastric cancer cell |
PSMA is expressed in the neovasculature of multiple nonprostatic solid tumors, it shows a unique expression pattern limited to tumor-associated endothelial cells. Expression in liver metastasis from colorectal cancers and lymph node metastasis from colorectal cancers |
708666 |
3.4.18.1 | cathepsin X |
gastric cancer cell |
- |
666147 |
3.4.21.107 | peptidase Do |
gastric cancer cell |
high HtrA1 expression levels |
683704 |
3.4.21.119 | kallikrein 13 |
gastric cancer cell |
- |
732961 |
3.4.21.46 | complement factor D |
gastric cancer cell |
- |
710586 |
3.4.21.B10 | neurosin |
gastric cancer cell |
high enzyme upregulation |
732962 |
3.4.21.B10 | neurosin |
gastric cancer cell |
KLK6 is upregulated |
679036 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
gastric cancer cell |
mainly located, seprase-expressing carcinoma tissue more often found in the scirrhous type than in other types of gastric carcinoma |
676269 |
3.4.21.B41 | kallikrein 10 |
gastric cancer cell |
- |
681167 |
3.4.21.B41 | kallikrein 10 |
gastric cancer cell |
significantly upregulated |
670979 |
3.4.21.B42 | hippostasin |
gastric cancer cell |
- |
718041 |
3.4.22.1 | cathepsin B |
gastric cancer cell |
of a more aggressive tumor type, cathepsin B is most common in the intestinal type tumors infiltrating the whole gastric wall |
698029 |
3.4.22.34 | Legumain |
gastric cancer cell |
legumain is overexpressed in the majority of human solid tumours, including breast cancer, colorectal cancer, ovarian cancer, prostate cancer and gastric cancer |
752851 |
3.4.22.38 | cathepsin K |
gastric cancer cell |
- |
697066 |
3.4.22.62 | caspase-9 |
gastric cancer cell |
caspase-9 mutations in the tumors are detected, the frequency of the mutations is very low and all the mutations are silent mutations that may not alter the function of the caspase protein. Caspase-9 gene mutation may not contribute to the pathogenesis of this cancer |
663673 |
3.4.22.B29 | calpain 9 |
gastric cancer cell |
suppressed or depleted in gastric cancer cell lines of differentiated and poorly differentiated types |
648099 |
3.4.22.B72 | SENP3 peptidase |
gastric cancer cell |
correlation between SENP3 expression and gastric cancer metastasis |
732595 |
3.4.24.23 | matrilysin |
gastric cancer cell |
high expression level |
710651 |
3.4.24.23 | matrilysin |
gastric cancer cell |
primary specimen, overexpression of MMP-7, realtime PCR, RT-PCR or Western blotting analysis |
707870 |
3.4.24.35 | gelatinase B |
gastric cancer cell |
- |
696967, 708542 |
3.4.24.35 | gelatinase B |
gastric cancer cell |
proteolytic activity and expression of gelatinase B in serum of gastric cancer patients and their correlation with the stage of the tumor |
684107 |
3.4.24.61 | nardilysin |
gastric cancer cell |
- |
733727 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
gastric cancer cell |
- |
638810 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
gastric cancer cell |
mRNA and protein levels of MMP14 are increased in gastric cancer cell. Upregulation of matrix metalloproteinase-14 expression contributes to metastatic properties of gastric cancer. MMP14 expression is related to advanced TNM stage, tumor grade, and lymph node metastasis. High expression of MMP14 and CDK7 are independent prognostic factors for overall survival in patients with gastric cancer |
761331 |
3.4.24.86 | ADAM 17 endopeptidase |
gastric cancer cell |
- |
753900 |
3.4.24.B3 | matrix metalloproteinase-11 |
gastric cancer cell |
- |
708156, 708668 |
3.4.24.B7 | matrix metalloproteinase-26 |
gastric cancer cell |
- |
710794 |
3.4.24.B9 | ADAM9 endopeptidase |
gastric cancer cell |
- |
668997 |
3.5.1.98 | histone deacetylase |
gastric cancer cell |
- |
713036 |
3.5.4.4 | adenosine deaminase |
gastric cancer cell |
- |
733602 |
3.6.1.29 | bis(5'-adenosyl)-triphosphatase |
gastric cancer cell |
- |
699134 |
4.1.1.17 | ornithine decarboxylase |
gastric cancer cell |
- |
698322 |
4.1.1.17 | ornithine decarboxylase |
gastric cancer cell |
relationship between expression level of the enzyme and mucosal proliferation, overview |
-, 747964 |
4.1.1.28 | aromatic-L-amino-acid decarboxylase |
gastric cancer cell |
different splicing variants |
748845 |
4.2.1.11 | phosphopyruvate hydratase |
gastric cancer cell |
ENOA is upregulated |
714970 |
5.1.99.4 | alpha-methylacyl-CoA racemase |
gastric cancer cell |
- |
728837 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
gastric cancer cell |
primary. Topo-IIalpha expression in the gastric adenocarcinoma is positively correlated with tumor location in the gastric cardia, intestinal histological type, late age onset of gastric adenocarcinoma, and male gender, but with no other clinicopathological parameters or with survival, overview |
714645 |
6.1.1.6 | lysine-tRNA ligase |
gastric cancer cell |
high expression of KRS in tumor cells is noted in 43.3 % (198 of 457) of the cases. High expression of KRS in tumor-associated inflammatory cells including macrophages/monocytes, CD4-positive T cells, and/or neutrophils is observed in 37.2 % (170 of 457) of the cases, overview |
744045 |
6.3.4.3 | formate-tetrahydrofolate ligase |
gastric cancer cell |
- |
765141 |
7.4.2.3 | mitochondrial protein-transporting ATPase |
gastric cancer cell |
- |
751766 |