EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
colonic cancer cell |
- |
668160, 695481 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
colonic cancer cell |
highly reduced enzyme expression in colon cancers, distribution of enzyme expression within the tissue in situ, overview |
-, 670691 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
colonic cancer cell |
- |
761665 |
1.1.1.21 | aldose reductase |
colonic cancer cell |
- |
713006, 721295, 722714 |
1.11.1.6 | catalase |
colonic cancer cell |
Caco-2 cell, increased activity of catalase in tumor cells recombinantly overexpressing IGFBP-2 probably mediated through IGF-independent mechanisms |
655696 |
1.13.11.19 | cysteamine dioxygenase |
colonic cancer cell |
- |
765832 |
1.13.11.20 | cysteine dioxygenase |
colonic cancer cell |
- |
765832 |
1.13.11.33 | arachidonate 15-lipoxygenase |
colonic cancer cell |
low expression |
706579 |
1.13.11.33 | arachidonate 15-lipoxygenase |
colonic cancer cell |
SW480 |
672902 |
1.13.11.34 | arachidonate 5-lipoxygenase |
colonic cancer cell |
high enzyme expression level |
686278 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
colonic cancer cell |
- |
726652 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
colonic cancer cell |
- |
755238 |
1.14.15.16 | vitamin D3 24-hydroxylase |
colonic cancer cell |
- |
728215 |
1.14.15.18 | calcidiol 1-monooxygenase |
colonic cancer cell |
- |
671357 |
1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase |
colonic cancer cell |
- |
755238 |
1.17.4.2 | ribonucleoside-triphosphate reductase (thioredoxin) |
colonic cancer cell |
- |
689295 |
1.3.5.2 | dihydroorotate dehydrogenase (quinone) |
colonic cancer cell |
- |
763351 |
1.4.3.13 | protein-lysine 6-oxidase |
colonic cancer cell |
- |
686947 |
1.5.3.13 | N1-acetylpolyamine oxidase |
colonic cancer cell |
- |
703028 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
colonic cancer cell |
BE human colon adenocarcinoma cells, stably NQO1-transfected BE-NQ cells69 |
688277 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
colonic cancer cell |
overexpression |
724356 |
2.1.1.357 | [histone H3]-lysine36 N-dimethyltransferase |
colonic cancer cell |
- |
753720 |
2.1.1.45 | thymidylate synthase |
colonic cancer cell |
- |
692655 |
2.1.2.2 | phosphoribosylglycinamide formyltransferase 1 |
colonic cancer cell |
- |
756648 |
2.1.2.2 | phosphoribosylglycinamide formyltransferase 1 |
colonic cancer cell |
xenograft HXGC3, HC1 and VRC5 |
485737 |
2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase |
colonic cancer cell |
- |
756643, 756648 |
2.2.1.1 | transketolase |
colonic cancer cell |
- |
690448 |
2.3.1.24 | sphingosine N-acyltransferase |
colonic cancer cell |
- |
754935 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
colonic cancer cell |
a reduction of O-acetylation is associated with the early stages of colorectal cancer |
672468 |
2.3.1.48 | histone acetyltransferase |
colonic cancer cell |
- |
756850 |
2.3.1.50 | serine C-palmitoyltransferase |
colonic cancer cell |
strong overexpression of both SPT subunits |
659621 |
2.3.1.85 | fatty-acid synthase system |
colonic cancer cell |
- |
704079, 705999 |
2.3.1.97 | glycylpeptide N-tetradecanoyltransferase |
colonic cancer cell |
- |
658408, 719244 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
colonic cancer cell |
- |
759884 |
2.4.1.244 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase |
colonic cancer cell |
- |
686974 |
2.4.1.244 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase |
colonic cancer cell |
enhanced expression in primary colon tumors |
688922 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
colonic cancer cell |
of patients with colorectal cancer 48% have down-regulated expression of beta-1,4-GT-IV in the tumor tissue, while 28% of patients exhibit elevated beta-1,4-GT-IV levels, the patient group with tumor beta-1,4-GT-IV overexpression strongly predicts for tumor metastasis, overview |
673117 |
2.4.1.41 | polypeptide N-acetylgalactosaminyltransferase |
colonic cancer cell |
ascending right part, low enzyme expression, decreased activity compared to normal colon, mono-glycosylates MUC5AC peptide |
489192 |
2.4.1.65 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase |
colonic cancer cell |
- |
678373 |
2.4.1.90 | N-acetyllactosamine synthase |
colonic cancer cell |
of patients with colorectal cancer 48% have down-regulated expression of beta-1,4-GT-IV in the tumor tissue, while 28% of patients exhibit elevated beta-1,4-GT-IV levels, the patient group with tumor beta-1,4-GT-IV overexpression strongly predicts for tumor metastasis, overview |
673117 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
colonic cancer cell |
- |
686976 |
2.4.2.10 | orotate phosphoribosyltransferase |
colonic cancer cell |
- |
672923 |
2.4.2.10 | orotate phosphoribosyltransferase |
colonic cancer cell |
colorectal cancer tissue |
674056 |
2.4.2.10 | orotate phosphoribosyltransferase |
colonic cancer cell |
colorectal cancer, 150 patients with cancer at different stages, stage-related enzyme expression level, overview |
677169 |
2.4.2.10 | orotate phosphoribosyltransferase |
colonic cancer cell |
in resectable colorectal cancer |
674045 |
2.4.2.3 | uridine phosphorylase |
colonic cancer cell |
- |
658264, 673810, 674032, 705806 |
2.4.2.3 | uridine phosphorylase |
colonic cancer cell |
colon tumor 38 |
658264 |
2.4.2.3 | uridine phosphorylase |
colonic cancer cell |
RPMI |
673810 |
2.4.2.3 | uridine phosphorylase |
colonic cancer cell |
RPMI colon tumor |
658264 |
2.4.2.31 | NAD+-protein-arginine ADP-ribosyltransferase |
colonic cancer cell |
- |
759782 |
2.4.2.4 | thymidine phosphorylase |
colonic cancer cell |
- |
638468, 638469, 674032, 685026 |
2.4.2.4 | thymidine phosphorylase |
colonic cancer cell |
patients with PD-ECGF/TP-positive tumors have a poorer prognosis than those with negative tumors |
673635 |
2.4.2.4 | thymidine phosphorylase |
colonic cancer cell |
WiDR, HT29 and Lovo |
658657 |
2.5.1.18 | glutathione transferase |
colonic cancer cell |
- |
759611 |
2.5.1.60 | protein geranylgeranyltransferase type II |
colonic cancer cell |
adenocarcinoma of colon, significant overexpression of RabGGT-beta compared to normal tissue |
658377 |
2.6.1.1 | aspartate transaminase |
colonic cancer cell |
- |
758821 |
2.6.1.52 | phosphoserine transaminase |
colonic cancer cell |
PSAT1 is overexpressed in colon tumors |
705666 |
2.7.1.105 | 6-phosphofructo-2-kinase |
colonic cancer cell |
- |
761915 |
2.7.1.107 | diacylglycerol kinase (ATP) |
colonic cancer cell |
- |
761306 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
colonic cancer cell |
- |
760540 |
2.7.1.137 | phosphatidylinositol 3-kinase |
colonic cancer cell |
- |
709003, 709906 |
2.7.1.149 | 1-phosphatidylinositol-5-phosphate 4-kinase |
colonic cancer cell |
- |
721493 |
2.7.1.32 | choline kinase |
colonic cancer cell |
- |
759595 |
2.7.1.91 | sphingosine kinase |
colonic cancer cell |
- |
671356, 675972, 703616 |
2.7.10.1 | receptor protein-tyrosine kinase |
colonic cancer cell |
- |
672895, 690303 |
2.7.10.1 | receptor protein-tyrosine kinase |
colonic cancer cell |
overexpression of EGFR-TK |
662724 |
2.7.11.20 | elongation factor 2 kinase |
colonic cancer cell |
- |
760308, 760810 |
2.7.11.22 | cyclin-dependent kinase |
colonic cancer cell |
- |
723073 |
2.7.11.26 | tau-protein kinase |
colonic cancer cell |
- |
703016 |
2.7.2.3 | phosphoglycerate kinase |
colonic cancer cell |
- |
761524 |
2.7.7.14 | ethanolamine-phosphate cytidylyltransferase |
colonic cancer cell |
the enzyme is downregulated in metastatic colon tumor |
722415 |
2.7.7.7 | DNA-directed DNA polymerase |
colonic cancer cell |
- |
691631 |
2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 |
colonic cancer cell |
- |
662996 |
3.1.1.23 | acylglycerol lipase |
colonic cancer cell |
expression of macrophage MGLL is decreased in cancer tissues |
751669 |
3.1.1.23 | acylglycerol lipase |
colonic cancer cell |
expression of macrophage MGLL is decreased in cancer tissues and positively correlated with the survival of cancer patients |
751669 |
3.1.1.4 | phospholipase A2 |
colonic cancer cell |
cPLA2-zeta2 |
707554 |
3.1.1.8 | cholinesterase |
colonic cancer cell |
- |
678541 |
3.1.3.16 | protein-serine/threonine phosphatase |
colonic cancer cell |
- |
679065 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
colonic cancer cell |
overexpression of isozyme PFKFB-4 in breast and colon malignant tumors compared to non-malignant tissue, overexpression of isozyme PFKFB-4 is correlated with enhanced expression of isozyme PFKFB-3, hypoxia-inducible factor 1alpha, dependent glucose transporter 1, and vascular endothelial growth factor VEGF, overview |
664248 |
3.1.4.12 | sphingomyelin phosphodiesterase |
colonic cancer cell |
- |
679649, 682477 |
3.1.4.12 | sphingomyelin phosphodiesterase |
colonic cancer cell |
mutation of the enzyme found in |
664216 |
3.1.6.2 | steryl-sulfatase |
colonic cancer cell |
- |
716213 |
3.1.6.2 | steryl-sulfatase |
colonic cancer cell |
immunohistochemistry: STS activity in 60% and 61% of patients with colon carcinoma, patients with no STS but estrogen sulfotransferase activity (-/+) have better clinical prognosis than all other activity pairs of these enzymes (+/-, +/+, -/-) |
691630 |
3.2.1.166 | heparanase |
colonic cancer cell |
- |
715737 |
3.4.11.18 | methionyl aminopeptidase |
colonic cancer cell |
- |
670444, 682206 |
3.4.11.18 | methionyl aminopeptidase |
colonic cancer cell |
MetAP2 is overexpressed in human colon cancer |
709910 |
3.4.13.19 | membrane dipeptidase |
colonic cancer cell |
- |
667944 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
colonic cancer cell |
colon cancer cell lines and colonic tumors |
731402 |
3.4.21.4 | trypsin |
colonic cancer cell |
- |
707900 |
3.4.21.53 | Endopeptidase La |
colonic cancer cell |
- |
731618 |
3.4.21.75 | Furin |
colonic cancer cell |
- |
708242 |
3.4.21.93 | Proprotein convertase 1 |
colonic cancer cell |
primary |
668083 |
3.4.21.94 | proprotein convertase 2 |
colonic cancer cell |
primary |
668083 |
3.4.21.B10 | neurosin |
colonic cancer cell |
quantitative real-time PCR enzyme expression analysis |
731404 |
3.4.21.B41 | kallikrein 10 |
colonic cancer cell |
significantly upregulated |
670979 |
3.4.22.1 | cathepsin B |
colonic cancer cell |
- |
697788 |
3.4.22.15 | cathepsin L |
colonic cancer cell |
- |
698329 |
3.4.22.40 | bleomycin hydrolase |
colonic cancer cell |
- |
36728 |
3.4.22.41 | cathepsin F |
colonic cancer cell |
- |
700574 |
3.4.22.43 | cathepsin V |
colonic cancer cell |
- |
669257 |