EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
breast cancer cell |
- |
700197 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
breast cancer cell |
expression of the enzyme and the estrogen receptor is correlated |
668162 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
breast cancer cell |
- |
656788, 763397 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
breast cancer cell |
3beta-hydroxysteroid dehydrogenase type 1 |
693887 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
breast cancer cell |
isozyme 3beta-HSD1 |
662371 |
1.1.1.188 | prostaglandin-F synthase |
breast cancer cell |
18fold increase in the median AKR1C3 mRNA levels in breast cancer patients as compared to those without disease |
697271 |
1.1.1.188 | prostaglandin-F synthase |
breast cancer cell |
of invasive ductal carcinoma of the breast, immunohistochemical analysis |
740999 |
1.1.1.205 | IMP dehydrogenase |
breast cancer cell |
- |
761611 |
1.1.1.213 | 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) |
breast cancer cell |
- |
675678 |
1.1.1.27 | L-lactate dehydrogenase |
breast cancer cell |
- |
740255 |
1.1.1.27 | L-lactate dehydrogenase |
breast cancer cell |
normal and malignant human breast tissues. The enzyme is highly expressed in breast |
740253 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
17beta-HSD7 is amplified in primary and progressive breast cancer |
763396 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
3beta-HSD1 is selectively expressed in human placenta, mammary glands and breast tumors in women |
763397 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
expression of 3beta-hydroxysteroid dehydrogenase type 1 (HSD3B1) in breast cancer is associated with shorter recurrence-free survival, and genetic or pharmacologic inhibition of HSD3B1 reduced colony formation and xenograft growth |
763404 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
selective expression of 3beta-HSD1 |
725813 |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
breast cancer cell |
- |
740017 |
1.1.1.37 | malate dehydrogenase |
breast cancer cell |
- |
760668 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
breast cancer cell |
- |
761332 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
breast cancer cell |
- |
740017 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
breast cancer cell |
- |
761900 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast cancer cell |
- |
685545, 711649, 713021, 726302, 740542, 740839, 740849, 761756, 761900 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast cancer cell |
17beta-HSD1 is overexpressed in many breast tumors |
688272 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast cancer cell |
the inhibition of the enzyme (17beta-HSD7) constitutes the basis of breast cancer cell proliferation |
761756 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
breast cancer cell |
- |
287331 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
breast cancer cell |
- |
659398 |
1.13.11.33 | arachidonate 15-lipoxygenase |
breast cancer cell |
- |
676925 |
1.13.11.53 | acireductone dioxygenase (Ni2+-requiring) |
breast cancer cell |
- |
764226 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
breast cancer cell |
- |
742572 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
breast cancer cell |
highly expressed |
439254 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
breast cancer cell |
P4HA2 mRNA levels are significantly upregulated in breast cancer compared to normal mammary tissue |
744594 |
1.14.11.27 | [histone H3]-dimethyl-L-lysine36 demethylase |
breast cancer cell |
- |
745919 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
breast cancer cell |
- |
725955 |
1.14.11.53 | mRNA N6-methyladenine demethylase |
breast cancer cell |
- |
739559, 765377 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
breast cancer cell |
- |
701223 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
breast cancer cell |
- |
711677, 756531 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
breast cancer cell |
high expression level of JARID1B |
711581 |
1.14.11.7 | procollagen-proline 3-dioxygenase |
breast cancer cell |
- |
697017 |
1.14.13.8 | flavin-containing monooxygenase |
breast cancer cell |
- |
673313 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
breast cancer cell |
- |
728211 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast cancer cell |
- |
671357, 695621 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast cancer cell |
the enzyme expression is reduced in breast cancer cell specimen compared to healthy breast tissue |
672857 |
1.14.19.17 | sphingolipid 4-desaturase |
breast cancer cell |
- |
744398, 744686 |
1.15.1.1 | superoxide dismutase |
breast cancer cell |
harbors MnSOD with the ala16val polymorphism |
716197 |
1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
breast cancer cell |
- |
743173 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
breast cancer cell |
- |
697114 |
1.2.1.31 | L-aminoadipate-semialdehyde dehydrogenase |
breast cancer cell |
- |
675897 |
1.3.1.1 | dihydropyrimidine dehydrogenase (NAD+) |
breast cancer cell |
- |
686604, 688302, 689367 |
1.4.3.13 | protein-lysine 6-oxidase |
breast cancer cell |
- |
687920, 713156 |
1.4.3.13 | protein-lysine 6-oxidase |
breast cancer cell |
circulating |
700903 |
1.4.3.13 | protein-lysine 6-oxidase |
breast cancer cell |
hypoxic |
697071 |
1.4.3.13 | protein-lysine 6-oxidase |
breast cancer cell |
lymph node-negative breast adenocarcinoma cell |
685957 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
breast cancer cell |
- |
762877 |
1.5.3.13 | N1-acetylpolyamine oxidase |
breast cancer cell |
- |
703028 |
1.5.3.16 | spermine oxidase |
breast cancer cell |
- |
690800, 711592 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
breast cancer cell |
- |
742556 |
1.8.1.9 | thioredoxin-disulfide reductase |
breast cancer cell |
- |
675915 |
1.8.3.2 | thiol oxidase |
breast cancer cell |
expression analysis of a panel of cDNAs derived from 50 clinically-graded normal and malignant breast tissue samples for the expression of QSOX1 mRNAs, significant correlation between relative transcript level and clinical grade malignant breast tumors |
743627 |
2.1.1.100 | protein-S-isoprenylcysteine O-methyltransferase |
breast cancer cell |
- |
704546 |
2.1.1.17 | phosphatidylethanolamine N-methyltransferase |
breast cancer cell |
- |
697843 |
2.1.1.220 | tRNA (adenine58-N1)-methyltransferase |
breast cancer cell |
- |
721024 |
2.1.1.244 | protein N-terminal methyltransferase |
breast cancer cell |
- |
736919 |
2.1.1.348 | mRNA m6A methyltransferase |
breast cancer cell |
- |
756331 |
2.1.1.355 | [histone H3]-lysine9 N-trimethyltransferase |
breast cancer cell |
- |
755156 |
2.1.1.357 | [histone H3]-lysine36 N-dimethyltransferase |
breast cancer cell |
- |
753720 |
2.1.1.361 | [histone H4]-lysine20 N-methyltransferase |
breast cancer cell |
- |
753133 |
2.1.1.56 | mRNA (guanine-N7)-methyltransferase |
breast cancer cell |
- |
757896 |
2.1.1.6 | catechol O-methyltransferase |
breast cancer cell |
- |
658443, 702678 |
2.1.2.1 | glycine hydroxymethyltransferase |
breast cancer cell |
expression patterns of SHMT2 in 76 breast cancer patients after modified radical mastectomy, immunohistochemic analysis, SHMT2 is highly expressed in breast cancer cells, and the expression level of SHMT2 is positively correlated with breast cancer grade |
736925 |
2.1.2.2 | phosphoribosylglycinamide formyltransferase 1 |
breast cancer cell |
- |
756648 |
2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase |
breast cancer cell |
- |
756648 |
2.2.1.1 | transketolase |
breast cancer cell |
TKTL1 expression in 86% of breast cancer specimens with 45% showing high expression levels |
694502 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
breast cancer cell |
neoplastic and adjacent, non-neoplastic glandular breast tissue specimens from human patients, expression analysis, reduced enzyme expression, LRAT protein progressively decreases with a reduction in the degree of tumor differentiation in invasive breast carcinomas, overview |
674069 |
2.3.1.21 | carnitine O-palmitoyltransferase |
breast cancer cell |
- |
757235 |
2.3.1.24 | sphingosine N-acyltransferase |
breast cancer cell |
isozymes CerS2 (EC 2.3.1.297) and CerS6 (EC 2.3.1.24) mRNA is significantly elevated in breast cancer tissue compared to normal tissue, with approximately half of the individuals showing elevated CerS2 and CerS6 mRNA. A significant correlation is found between CerS2 and CerS6 isozyme expression, and between isozymes CerS4 (EC 2.3.1.24) and CerS2/CerS6 expression |
752644 |
2.3.1.291 | sphingoid base N-palmitoyltransferase |
breast cancer cell |
- |
752733 |
2.3.1.297 | very-long-chain ceramide synthase |
breast cancer cell |
isozymes CerS2 (EC 2.3.1.297) and CerS6 (EC 2.3.1.24) mRNA is significantly elevated in breast cancer tissue compared to normal tissue, with approximately half of the individuals showing elevated CerS2 and CerS6 mRNA. A significant correlation is found between CerS2 and CerS6 isozyme expression, and between isozymes CerS4 (EC 2.3.1.24) and CerS2/CerS6 expression |
752644 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
breast cancer cell |
- |
677235 |
2.3.1.48 | histone acetyltransferase |
breast cancer cell |
- |
703846, 735352, 756658, 756850, 758109 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
- |
735771, 735849, 756146 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
methylation status and the transcriptional activity of NAT1 in breast cancer tissues: methylation of NAT1 gene is identified in 39 of the breast carcinomas (54.2%), 23 normal (76.7%) and 25 benign breast tissue samples (80.6%). Breast cancer tissues show significantly lower methylation rates of the NAT1 promoters than the normal and benign tissues. Cancer tissues show lower methylation density rates than normal and benign breast tissues. Tissues that show aberrant methylation of NAT1 show significantly less mRNA expression compared with the unmethylated cases. 20 cancers from the methylated group show positive staining for the estrogen receptor (ER) (51.3%), while 72.7% from the unmethylated group stain positive |
689296 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
NAT1 is overexpressed in estrogen receptor-positive breast cancer |
686256 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
patients with ductal carcinoma |
676155 |
2.3.1.57 | diamine N-acetyltransferase |
breast cancer cell |
- |
756851 |
2.3.1.57 | diamine N-acetyltransferase |
breast cancer cell |
in breast tumors, SSAT is increased contributing to an increase in acetylated polyamines |
701622 |
2.3.1.85 | fatty-acid synthase system |
breast cancer cell |
- |
704079, 705999 |
2.3.1.B43 | protein-lysine desuccinylase (NAD+) |
breast cancer cell |
- |
758247 |
2.3.1.B46 | 1-acylglycerophosphatidylinositol O-acyltransferase |
breast cancer cell |
- |
757632 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
breast cancer cell |
MDA-MB-231 (doxorubicin resistant) human breast cancer cell |
685934 |
2.3.2.2 | gamma-glutamyltransferase |
breast cancer cell |
- |
694485 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
breast cancer cell |
- |
759882 |
2.4.1.150 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase |
breast cancer cell |
GCNT2 is overexpressed in highly metastatic breast cancer cell lines. GCNT2 expression is also significantly correlated to the metastatic phenotype in breast tumor samples |
758992 |
2.4.1.152 | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase |
breast cancer cell |
- |
735901 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
breast cancer cell |
- |
693867 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
breast cancer cell |
epithelial and metastatic |
758997 |
2.4.1.212 | hyaluronan synthase |
breast cancer cell |
- |
736064, 736145 |
2.4.1.222 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
breast cancer cell |
manic fringe is highly expressed in claudin-low breast cancer |
735881 |
2.4.1.313 | protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase |
breast cancer cell |
- |
725164 |
2.4.1.80 | ceramide glucosyltransferase |
breast cancer cell |
- |
722787, 736201 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
breast cancer cell |
- |
735872 |
2.4.2.3 | uridine phosphorylase |
breast cancer cell |
- |
705806 |