EC Number   |
General Information |
Reference |
|---|
    2.6.1.1 | malfunction |
a cold-sensitive mutant is generated by transposon mutagenesis. The mutated gene in CSM2 is identified as AAT. Complementation of AAT in CSM2 restores the original phenotype as in the wild-type cells |
721457 |
| 2.6.1.1 | malfunction |
decreased enzyme activity induces calpain activation by increasing the cytosolic Ca2+ concentrations of BV2 microglia, resulting in mitochondrial depolarization and cell death |
759851 |
| 2.6.1.1 | malfunction |
enzyme deficiency leads to virulence attenuation in macrophages and mice |
-, 759824 |
| 2.6.1.1 | malfunction |
enzyme deficient fission yeast cells display auxotrophy to aspartate |
759497 |
| 2.6.1.1 | metabolism |
the catalytic activity of the enzyme is required for TOR complex 1 activation. The catalytic site of the enzyme is required for rapamycin resistance |
759497 |
| 2.6.1.1 | more |
key residues, such as Glu108, are involved in both keto acid and amino acid substrate specificities and probably contribute to the evolution of PAT activity among class Ibeta AAT enzymes, ligand binding study, molecular mechanisms underlying recognition of keto acid and amino acid substrates, overview. Lys306 is the catalytic Lys in AtPAT |
759965 |
| 2.6.1.1 | physiological function |
aspartate aminotransferase AAT3 is an infection-inducible expression gen. Silencing of AAT3 reduces Phytophthora sojae pathogenicity on soybean plants and affects the growth under N-starving condition |
-, 738311 |
| 2.6.1.1 | physiological function |
involved in liver glyceroneogenesis |
704082 |
| 2.6.1.1 | physiological function |
knockout mutant exhibits little or no growth, and gene alr4853 is a Fox gene (requiring fixed N2 for growth in the presence of oxygen) |
-, 739018 |
| 2.6.1.1 | physiological function |
knockout mutant exhibits reduced diazotrophic growth |
-, 739018 |
