EC Number   |
General Information |
Reference |
|---|
   1.1.1.67 | malfunction |
dysfunction of the mitochondrial complex I decreases the level of NAD+, downregulates the NAD+-dependent mannitol dehydrogenase activity, and inhibits hyphal growth and biofilm formation in conditions when the carbon source is mannitol, but not fermentative sugars like glucose |
763630 |
| 1.1.1.67 | metabolism |
Thermotoga neapolitana oxidizes D-fructose directly to D-mannitol in one step |
763052 |
| 1.1.1.67 | more |
the enzyme synthesizes D-mannitol is commonly known as a sweetener in food manufacturing such as juices, soft drinks, cakes, and sweet cookies, moreover, other processing including alternative sugar for diabetic patients, cosmetics, personal hygiene products, and laxative. D-mannitol is 50% as sweet as sucrose |
-, 763052 |
| 1.1.1.67 | more |
the enzyme synthesizes D-mannitol is commonly known as a sweetener in food manufacturing such as juices, soft drinks, cakes, and sweet cookies, moreover, other processing including alternative sugar for diabetic patients, cosmetics, personal hygiene products, and laxative. D-mannitol is 50% as sweet as sucrose. The residues of the catalytic domain involved in the catalytic mechanism and zinc-binding sites in Thermotoga neapolitana MtDH structure appear to relocate between different structures via cysteine in the active site. Cysteine and glycine residues are commonly conserved in most thermophilic MtDHs. The Cys91, Cys94, Cys97, and Cys105 residues at the enzyme active site are either bare or have non-functional metal binding. The residues predicted to be involved in the reaction chemistry are Asn86, Leu109, and Asp82, docking studies |
763052 |
