EC Number   |
Expression |
Reference |
|---|
   2.4.1.212 | down |
HAS2 is the major isoenzyme in MCF-7 cells. The mRNA expression is lowered by 4-methylumbelliferone by 81% in MCF-7 cells, and by 88% in A2058 cells. Both HAS substrate and HAS2 and/or HAS3 mRNA are targeted by 4-methylumbelliferone. The reduction of hyaluronan caused by 4-methylumbelliferone is associated with a significant inhibition of cell migration, proliferation and invasion |
703583 |
| 2.4.1.212 | down |
histamine increases hyaluronan degradation by up-regulating HYBID (hyaluronan-binding protein) and down-regulating hyaluronan synthase 2 in human skin fibroblasts in a dose- and time-dependent manner and thereby decreases the total amounts and sizes of newly produced hyaluronan |
759505 |
| 2.4.1.212 | down |
in MDA-MB-361, A2058 and SKOV-3 cells, treatment with 4-methylumbelliferone decreases HAS3 mRNA by 84-60%. The reduction of hyaluronan caused by 4-methylumbelliferone is associated with a significant inhibition of cell migration, proliferation and invasion |
703583 |
| 2.4.1.212 | down |
isozyme HAS2 is suppressed in senescent fibroblasts |
736725 |
| 2.4.1.212 | down |
reduced HAS 2 gene expression and increased excreted urinary hyaluronidase activity during dehydration contribute to the reduced amount of hyaluronan and to antidiuretic response |
705486 |
| 2.4.1.212 | down |
the enzyme expression is decreased in transcriptional regulation by estradiol, 4-methylumbelliferone, and TGF-beta1 |
736145 |
| 2.4.1.212 | down |
transforming grwoth factor 1beta significantly inhibits HAS3 expression and protein formation |
702937 |
| 2.4.1.212 | more |
comparison of full-length HAS1 isoform and its splice variants Va, Vb, and Vc. When co-expressed, the properties of HAS1 variants are dominant over those of full length HAS1. Full length HAS1 appears to be diffusely expressed in the cell, but HAS1 variants are concentrated in the cytoplasm and/or Golgi apparatus. HAS1 variants synthesize detectable de novo hyaluronan intracellularly. Each of the HAS1 variants is able to relocalize full length HAS1 protein from diffuse cytoskeleton-anchored locations to deeper cytoplasmic spaces. The HAS1-variants-mediated relocalization occurs through strong molecular interactions, which also serve to protect full length HAS1 from its otherwise high turnover kinetics |
704503 |
| 2.4.1.212 | up |
17beta-estradiol and different combinations of estradiol, gonadotropins, insulin-like growth factor 1 and insulin iduce the enzyme expression of HAS1-3 |
737218 |
| 2.4.1.212 | up |
17beta-estradiol and different combinations of estradiol, gonadotropins, insulin-like growth factor 1 and insulin iduce the expression of HAS1-3 |
737218 |
