EC Number   |
Reaction |
Reference |
|---|
   2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate |
an ordered binding mechanism for enzyme where geranylgeranyl diphosphate adds before peptide |
636544 |
| 2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate |
catalyses the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein, these protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine, but serine, methionine, alanine or glutamine makes the protein a substrate for EC 2.5.1.58, the enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic, known targets of this enzyme include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families |
636537, 636546 |
| 2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate |
enzyme and geranylgeranyl diphosphate produce a stable binary complex and the tightly bound geranylgeranyl diphosphate is transferred to a peptide acceptor, without the equilibration of enzyme-bound geranylgeranyl diphosphate with free geranylgeranyl diphosphate |
636538, 636539 |
| 2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate |
random sequential mechanism |
636539, 636540 |
| 2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate |
this enzyme, along with protein farnesyltransferase, EC 2.5.1.58 and protein geranylgeranyltransferase type II, EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes |
636537, 636539, 636540, 636541, 636543, 636544, 636546, 636548, 636549 |
