EC Number   |
Application |
Reference |
|---|
    2.3.1.37 | agriculture |
with high irradiance, transgenic rice lines P5 and P14 expressing 5-aminolevulinate synthase show a decrease in contents of chlorophyll and the chloroplast-encoded gene psbA mRNA, whereas a decrease in light-harvesting Chl-binding proteins is observed only in P14. These effects are not observed in the wild-type or all of the lines treated with low irradiance. High irradiance results in a greater decrease in the quantum yield of photosystem 2 and a greater increase in nonphotochemical quenching in the transgenic lines, particularly in P14. Photoprotective zeaxanthin contents increase at high irradiance, even though carotenoid contents are lower in the transgenic lines. When exposed to high irradiance, superoxide dismutase greatly increased in transgenic lines P5 and P14, but peroxidase and glutathione reductase increases only in P14, in which more photodynamic damage occurrs |
706104 |
| 2.3.1.37 | biotechnology |
Propionibacterium acidipropionici TISTR442 produce the highest amount of 5-aminolevulinic acid (ALA) when cultivated in medium supplemented with glycine at 18 g/l. This optimal condition for ALA production via the addition of glycine provides an easy and low-cost technique for themass cultivation of Propionibacterium acidipropionici |
720074 |
| 2.3.1.37 | medicine |
delivery of stable and highly active ALAS2 variants has the potential to expand and improve upon current photodynamic therapies regimes |
737145 |
| 2.3.1.37 | medicine |
hypoxia induces the expression of TGF-beta1 and mitoferrin mRNAs through separate mechanisms in erythroid cells. TGF-beta1 subsequently induces erythroidspecific 5-aminolevulinate synthase ALAS2 expression |
703635 |
| 2.3.1.37 | medicine |
in mouse model of erythropoietic protoporphyria, isoflurane induces 5-aminolevulinate synthase activity and increases excretion of porphyrin precursors. Mice homozygotically lacking ferrochelatase activity and receiving anaestesia show enhanced 5-aminolevulinate synthase and Cyp2E1 activities in the liver and increased urinary excretion of porphyrin precursors |
703125 |
| 2.3.1.37 | medicine |
the relative expression of ALAS1 mRNA, the first and rate-limiting enzyme for heme biosynthesis under normal physiological conditions, is significantly reduced by nearly 90% in patients with Alzheimer's disease compared to control. The relative expression of porphobilinogen deaminase mRNA, the third enzyme in the heme synthesis pathway and a secondary rate-limiting enzyme in heme biosynthesis, is also significantly reduced by nearly 60% in brain of patients with Alzheimer's disease and significantly related to apolipoprotein E genotype. The relative expression of aminolevulinate dehydratase mRNA, the second and a non-rate-limiting enzyme for heme biosynthesis, is unchanged between the two groups |
705917 |
| 2.3.1.37 | medicine |
three-dimensional structural model of enzyme, mapping of a range of human mutants that give rise to X-linked sideroblastic anemia |
661232 |
| 2.3.1.37 | nutrition |
enzyme expressed in transgenic Nicotiana tabacum plants demonstrate functional complementation in the chlorophyll biosynthesis and open strategies for producing tolerance against inhibitors of the C5 pathway |
486854 |
| 2.3.1.37 | pharmacology |
enzyme is a target for drug development because of its immunological and inhibitor specificity |
486860 |
| 2.3.1.37 | synthesis |
by expression in Escherichia coli Rosetta and combining D-xylose as a inhibitor for 5-aminolevulinate dehydratase with D-glucose in fed-batch culture and based on the optimal culture system, the yield of 5-aminolevulinate achieved is 7.3 g/l or 56 mM under the appropriate conditions |
691351 |
