EC Number   |
Application |
Reference |
|---|
    2.1.3.3 | analysis |
after administration of carbon tetrachloride, allyl alcohol, D-galactosamine, lipopolysaccharide, and concanavalin A, the significant increase in the serum levels of the markers is faster in type-I arginase and ornithine carbamoyltransferase than aspartate aminotransferase and alanine aminotransferase. The extent of the increase at the peak is always higher in type-I arginase and ornithine carbamoyltransferase than in spartate aminotransferase and alanine aminotransferase |
697391 |
| 2.1.3.3 | biotechnology |
HepG2 is an immortalized human hepatoma cell line that has been used for research into bioartificial liver systems. However, a low level of ammonia detoxification is its biggest drawback. Stable overexpression of arginase I and ornithine transcarbamylase in HepG2 cells improves its ammonia detoxification |
720095 |
| 2.1.3.3 | diagnostics |
ornithine carbamoyltransferase is one promising blood-based biomarker candidate for liver injury examination |
-, 736014 |
| 2.1.3.3 | diagnostics |
the enzyme alone or in combination with other markers is a useful indicator for Kupffer cell activation as well as for mitochondrial damage in hepatic cells |
673136 |
| 2.1.3.3 | diagnostics |
the enzyme can be used as biomarker for early stage of hepatic injury induced by CCl4, diagnostics values are best in combination with total bile acid and phosphorylase measurements |
-, 735966 |
| 2.1.3.3 | medicine |
after administration of carbon tetrachloride, allyl alcohol, D-galactosamine, lipopolysaccharide, and concanavalin A, the significant increase in the serum levels of the markers is faster in type-I arginase and ornithine carbamoyltransferase than aspartate aminotransferase and alanine aminotransferase. The extent of the increase at the peak is always higher in type-I arginase and ornithine carbamoyltransferase than in spartate aminotransferase and alanine aminotransferase |
697391 |
| 2.1.3.3 | medicine |
enzyme downregulation is associated with poor prognosis in hepatocellular carcinoma |
757879 |
| 2.1.3.3 | medicine |
in patients with Alzheimer's disease, ornithine carbamoyltransferase is expressed in brain, but not in controls. Ornithine carbamoyltransferase expression is strictly restricted to vascular endothelial cells. Ornithine carbamoyltransferase activity is 880% increased in the cerebrospinal fluid of probable Alzheimer's disease cases compared with controls. Rare haplotypes may be associated with the risk of Alzheimer's disease through a possible modulation of the methylation of the ornithine carbamoyltransferase promoter |
700311 |
| 2.1.3.3 | medicine |
in patients with non-alcoholic steatohepatitis, the serum levels of ornithine carbamoyltransferase and the ratios of ornithine carbamoyltransferase:alanine amino transferase and ornithine carbamoyltransferase:aspartate amino transferase are increased in parallel with the progression of on-alcoholic steatohepatitis. Especially, ornithine carbamoyltransferase and both ratios are markedly increased in hepatocellular carcinoma. As for the relationship between fibrosis grade and ornithine carbamoyxltransferase, the serum ornthine carbamoyltransferase levels and theratio of ornithine carbamoyltransferase:alanine amino transferase levels are increased in parallel with liver fibrosis. In non-alcoholic steatohepatitis patients with alanine amino transferase within normal range, about 30% show elevation of ornithine carbamoyltransferase |
698155 |
| 2.1.3.3 | medicine |
measurement of serum enzyme concentration is a useful marker of disease severity, and thus can be a useful marker for a high risk of hepatocellular carcinoma occurrence |
756979 |
