EC Number   |
Application |
Reference |
|---|
   1.1.1.149 | analysis |
the enzyme is a marker for the murine X-zone |
-, 668428 |
| 1.1.1.149 | biotechnology |
a process is developed that that allows the production of 20alpha- dihydrodydrogesterone at technical scale (several grams of 20a-DHD per week and fermenter). Genetic improvement of the production strain, an increase of substrate solubility by addition of ß-cyclodextrin, and the development of a sophisticated high-cell density fermentation at pilot scale are employed. By usage of the exemplary substrate progesterone, it is hsown that this innovative fission yeast-based whole cell biotransformation process is transferable to the conversion of other AKR1C1 substrates without special adaptation |
723969 |
| 1.1.1.149 | biotechnology |
an aldo-keto reductases-dependent whole-cell biotransformation process is established that can be used for production of human aldo-keto reductases metabolites on a large scale |
725580 |
| 1.1.1.149 | environmental protection |
diesel exhaust components are inhibitory on 20alpha-hydroxysteroid dehydrogenase in liver and lung cytosol, with little inhibition in kidney cytosol |
688031 |
| 1.1.1.149 | food industry |
the enzyme can alter glucocorticoid metabolism in the gut and thereby serves as potential probiotics for the management of androgen-dependent diseases |
-, 763262 |
| 1.1.1.149 | medicine |
diesel exhaust components are inhibitory on 20alpha-hydroxysteroid dehydrogenase in liver and lung cytosol, with little inhibition in kidney cytosol |
688031 |
| 1.1.1.149 | medicine |
enzyme activity is 8-14fold higher in nontumorgenic strain MCF-10A than in tumorgenic strains MCF-7, MDA-MB-231, T-47D |
655129 |
| 1.1.1.149 | medicine |
targeted disruption of 20alpha-hydroxysteroid dehydrogenase gene results in complete loss of catalytic activity and lack of increase in serum concentrations of 20alpha-dihydroprogesterone during pseudopregnancy or pregnancy. The durations of the estrious cycle, pseudopregnancy, and pregnancy are significantly prolonged in the mutant mice, and the number of pups, espcially live pups, is markedly decreased |
688665 |
