2.4.1.214 | more |
interleukin-12 i.e. IL-12, and TGF-beta1 strongly induce the enzyme in activated T-cells, IL-12 and TGF-beta1 are important for homing of the T-cells to inflammation sites in the skin and gut, respectively, via selectins, which are bound by ligands expressed by the T-cells involving the enzyme, induction by TGF-beta1 can be blocked by p38 mitogen-activated protein kinase, but is unaffected by mitogen-activated protein/extracellular signal-related kinase kinase inhibitor, overview |
662566 |